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Diabetes:磁共振神经成像可视化1型糖尿病和神经病变患者坐骨神经和胫神经异常!

2017-04-23 xing.T MedSci原创

总之,DTI-MRN可以检测与DPN相关的外周神经病变,并且比质子自旋密度和T2弛豫时间更好。这些异常可能反映了坐骨神经和胫神经纤维的病理学。

近日,糖尿病领域权威杂志Diabetes上发表了一篇研究文章,研究人员旨在评估扩散张量成像MR神经成像(DTI-MRN),T2弛豫时间和质子自旋密度能否可以检测并分级1型糖尿病患者的神经性异常。

49例1型糖尿病患者(11例为严重多发性神经病(sDPN),13例为轻度多发性神经病(mDPN)和25例无多发性神经病(nDPN))和30名健康对照者(HC)内纳入研究。研究人员通过临床检查、神经传导检测和振动感知阈值来确定DPN的存在和严重程度。DTI-MRN检查了下肢近端(坐骨神经)和远端(胫神经)的神经节段。研究人员计算了分数各向异性(FA)和表观弥散系数(ADC),并与从DTI-MRN检查中获得的T2弛豫时间和质子自旋密度一起:所有的MR表现均与病变的存在和严重程度相关。

sDPN组患者坐骨神经和胫神经的FA最低。相应地,sDPN组患者近端和远端的ADC也是最高的,相比于mDPN和nDPN患者以及HC。DTI-MRN与神经病变的严重性密切相关,表明坐骨神经和胫神经的结果具有强大的相关性。定量质子自旋密度的组差异也较为显著,但没有DTI-MRN明显。

总之,DTI-MRN可以检测与DPN相关的外周神经病变,并且比质子自旋密度和T2弛豫时间更好。这些异常可能反映了坐骨神经和胫神经纤维的病理学。

原始出处:

Michael Vaeggemose, et al. Magnetic Resonance Neurography Visualizes Abnormalities in Sciatic and Tibial Nerves in Patients with Type 1 Diabetes and Neuropathy.Diabetes 2017 Apr; db161049. https://doi.org/10.2337/db16-1049

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  5. 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  6. 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18:58:03 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189934, encodeId=34fd18993417, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/30/dd6bade062cb598667f9f577194196c4.jpg, createdBy=422e1687020, createdName=Dr.jerry, createdTime=Sun Apr 23 14:28:31 CST 2017, time=2017-04-23, status=1, ipAttribution=)]
    2017-04-25 axin012
  7. 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  8. 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  9. 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18:58:03 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189934, encodeId=34fd18993417, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/30/dd6bade062cb598667f9f577194196c4.jpg, createdBy=422e1687020, createdName=Dr.jerry, createdTime=Sun Apr 23 14:28:31 CST 2017, time=2017-04-23, status=1, ipAttribution=)]
    2017-04-23 1dd8aa01m06(暂无匿称)

    学习了很好的内容

    0

  10. 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18:58:03 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189934, encodeId=34fd18993417, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/30/dd6bade062cb598667f9f577194196c4.jpg, createdBy=422e1687020, createdName=Dr.jerry, createdTime=Sun Apr 23 14:28:31 CST 2017, time=2017-04-23, status=1, ipAttribution=)]
    2017-04-23 Dr.jerry

    谢谢

    0

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