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J Viral Hepat:在感染了丙型肝炎的埃及人群中,经DAA治疗后,患者肝细胞癌的复发率增加

2017-12-26 MedSci MedSci原创

研究结果为DAAs在HCC患者复发中的可能作用提供了重要证据,并强调需要进一步的研究和临床试验,以确认这一作用,并确定可能与此事件相关的患者特征。

研究背景:在埃及,肝细胞癌是最普遍的癌症,使用直接抗病毒药物(DAA)对慢性丙肝病毒感染患者进行大规模的治疗以降低风险。在这一独特的背景下,本研究的目的是在HCV相关肝癌的患者中,确定DAA暴露与早期HCC复发之间的关系。

研究方法:本研究是一项前瞻性队列研究,研究对象来自埃及一家专业的HCC管理中心。在接受DAA治疗和未接受DAA治疗的患者间,比较HCC复发率。DAA治疗随着时间变化。采用泊松回归模型控制暴露组和非暴露组间的潜在差异。

研究结果:本研究共纳入116例患者,53例患者采用DAA治疗,63例患者未采用DAA治疗。在中位随访16个月和23个月时,每组HCC的复发率分别是37.7%和25.4%。泊松回归显示出DAAs和HCC复发之间的相关性,发病率比为3.83(95% CI:2.02 - 7.25),在多变量调整模型和各种敏感性分析中得到了相似的结果。

研究结论:研究结果为DAAs在HCC患者复发中的可能作用提供了重要证据,并强调需要进一步的研究和临床试验,以确认这一作用,并确定可能与此事件相关的患者特征。

原始出处


El, KM, Funk AL, Salaheldin, M, et al. Increased recurrence rates of hepatocellular carcinoma after DAA therapy in a hepatitis C infected Egyptian cohort: a comparative analysis. J Viral Hepat, 2017, 2017 Dec 23. doi: 10.1111/jvh.12854.

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    2018-12-05 xjy02
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  6. [GetPortalCommentsPageByObjectIdResponse(id=1922417, encodeId=6971192241e2d, content=<a href='/topic/show?id=4a80425e534' target=_blank style='color:#2F92EE;'>#复发率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42575, encryptionId=4a80425e534, topicName=复发率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Mon Apr 09 16:16:00 CST 2018, time=2018-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978627, encodeId=1ddb19e862727, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Thu Aug 09 03:16:00 CST 2018, time=2018-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863335, encodeId=107918633357f, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Wed Dec 05 11:16:00 CST 2018, time=2018-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1642221, encodeId=d63516422213a, content=<a href='/topic/show?id=455e4156e69' target=_blank style='color:#2F92EE;'>#埃及#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41567, encryptionId=455e4156e69, topicName=埃及)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b10c22881502, createdName=12498d2fm58(暂无昵称), createdTime=Fri Dec 07 12:16:00 CST 2018, time=2018-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1274616, encodeId=1c7012e4616f8, content=<a href='/topic/show?id=30872089e03' target=_blank style='color:#2F92EE;'>#丙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20897, encryptionId=30872089e03, topicName=丙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Thu Dec 28 11:16:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361831, encodeId=f6e71361831b9, content=<a href='/topic/show?id=a88b564ea6' target=_blank style='color:#2F92EE;'>#DAA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5647, encryptionId=a88b564ea6, topicName=DAA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Thu Dec 28 11:16:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426958, encodeId=4ad314269585f, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Thu Dec 28 11:16:00 CST 2017, time=2017-12-28, status=1, ipAttribution=)]
    2017-12-28 qingting
  7. [GetPortalCommentsPageByObjectIdResponse(id=1922417, encodeId=6971192241e2d, content=<a href='/topic/show?id=4a80425e534' target=_blank style='color:#2F92EE;'>#复发率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42575, encryptionId=4a80425e534, topicName=复发率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Mon Apr 09 16:16:00 CST 2018, time=2018-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978627, encodeId=1ddb19e862727, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Thu Aug 09 03:16:00 CST 2018, time=2018-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863335, encodeId=107918633357f, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Wed Dec 05 11:16:00 CST 2018, time=2018-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1642221, encodeId=d63516422213a, content=<a href='/topic/show?id=455e4156e69' target=_blank style='color:#2F92EE;'>#埃及#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41567, encryptionId=455e4156e69, topicName=埃及)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b10c22881502, createdName=12498d2fm58(暂无昵称), createdTime=Fri Dec 07 12:16:00 CST 2018, time=2018-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1274616, encodeId=1c7012e4616f8, content=<a href='/topic/show?id=30872089e03' target=_blank style='color:#2F92EE;'>#丙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20897, encryptionId=30872089e03, topicName=丙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Thu Dec 28 11:16:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361831, encodeId=f6e71361831b9, content=<a href='/topic/show?id=a88b564ea6' target=_blank style='color:#2F92EE;'>#DAA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5647, encryptionId=a88b564ea6, topicName=DAA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Thu Dec 28 11:16:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426958, encodeId=4ad314269585f, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Thu Dec 28 11:16:00 CST 2017, time=2017-12-28, status=1, ipAttribution=)]
    2017-12-28 gwc384

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