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2019 EHA:TG Therapeutics的抗CD47 / CD19双特异性抗体TG-1801临床前抗淋巴瘤作用显著

2019-06-18 不详 MedSci原创

第 24 届欧洲血液学协会(EHA)年会上,TG Therapeutics宣布推出TG-1801的临床前数据。TG-1801是一种抗CD47 / CD19的双特异性抗体,可选择性地靶向CD19 + B细胞上的CD47,并阻断成熟B细胞上的CD47-SIRPα介导的'不要吃我'的自我保护信号,来发挥抗肿瘤的作用。

第 24 届欧洲血液学协会(EHA)年会上,TG Therapeutics宣布推出TG-1801的临床前数据。TG-1801是一种抗CD47 / CD19的双特异性抗体,可选择性地靶向CD19 + B细胞上的CD47,并阻断成熟B细胞上的CD47-SIRPα介导的'不要吃我'的自我保护信号,来发挥抗肿瘤的作用。

与利妥昔单抗相比,Ublituximab在B-NHL细胞中发挥更强的ADCP和ADCC活性。并且TG-1801与U2:ublituximab(公司的抗CD20单克隆抗体)和umbralisib(公司的PI3K-delta抑制剂),联合应用具有协同的肿瘤生长抑制作用,该效应似乎是由免疫效应细胞的浸润增加所介导的。

该公司执行主席兼首席执行官Michael S. Weiss表示:"TG-1801是一种一流的抗CD47 / CD19双特异性抗体,特异性靶向CD19表达细胞,以避免脱靶CD47毒性,代表了一种新的免疫治疗策略。TG-1801的临床前数据让我们感到非常兴奋,期待在我们正在进行的TG-1801 1期临床研究中评估TG-1801作为单一药物治疗B细胞恶性肿瘤患者的潜力。"

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    2020-01-13 feather89
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    2019-11-03 qidongfanjian
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  8. 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    2019-06-20 dingxiaobo
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    2019-06-20 qjddjq
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