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J Clin Periodontol: :成人失牙数与非酒精性脂肪性肝病的关系

2018-08-19 MedSci MedSci原创

长期口腔慢性炎症与全身炎症密切相关,而全身炎症是非酒精性脂肪性肝病(NAFLD)的主要机制。牙齿缺失可以反映口腔局部炎症的情况,这意味着缺牙的数量可能与NAFLD有关。本研究评估了一般人群中缺失牙齿与NAFLD存在之间的关系。

长期口腔慢性炎症与全身炎症密切相关,而全身炎症是非酒精性脂肪性肝病(NAFLD)的主要机制。牙齿缺失可以反映口腔局部炎症的情况,这意味着缺牙的数量可能与NAFLD有关。本研究评估了一般人群中缺失牙齿与NAFLD存在之间的关系。

试验纳入24,470名来自天津慢性低度系统性炎症和健康队列的成年人。记录自我报告的缺牙数(不包括第三磨牙)并将其分为四类:0,1-2,3-5和≥6。通过肝脏超声检查确诊NAFLD。通过调整的多变量逻辑回归分析两者之间的关联。

结果:在各类缺失牙齿中,NAFLD的多变量校正比值比(95%置信区间)分别为:男性中,1.00(参考值),1.04(0.93-1.16),1.06(0.90-1.24)和1.40(1.09) -1.81)(趋势p= 0.04);在女性中,1.00(参考值),0.98(0.83-1.15),1.11(0.90-1.37)和1.07(0.77-1.48)(趋势p = 0.45)。

结论:缺牙数量与男性NAFLD的高发病率相关,而女性没有。

原始出处:

Feng Qiao, et al. The association between missing teeth and non‐alcoholic fatty liver disease in adults. Journal of Clinical Periodontology. 2018 August. doi: 10.1111/jcpe.12929

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    2019-07-19 feather89
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    2018-12-05 qjddjq
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