Brit J Cancer：2型糖尿病与结直肠癌风险

2018-11-08 xing.T MedSci原创

由此可见，该研究的结果支持T2D与男性患CRC的风险中度相关; 在女性中观察到较弱的，但无显著性的正相关。

以前的研究表明，2型糖尿病（T2D）与结直肠癌（CRC）风险之间存在正相关关系。然而，不确定这种关联是否因T2D病程长短或性别而有所不同。近日，肿瘤领域权威杂志British Journal of Cancer上发表了一篇研究文章，研究人员调查了T2D及其病程长短与CRC发生风险之间的关系。

研究人员随访了来自护士健康研究（1980-2012）的87523名女性和来自卫生专业人员随访研究（1986-2012）的47240名男性。在基线时通过问卷收集了医生诊断的T2D数据，并每两年更新一次。Cox回归模型用于估计多变量调整后的风险比（HRs）和95％置信区间（CIs）。

在长达32年的随访期间，研究人员记录了3000例CRC病例。在男性中，与没有T2D的患者相比，T2D与CRC风险增加相关（HR为1.42; 95％CI为1.12-1.81）。通过排除在糖尿病诊断后1年内确定的CRC和服用降血糖药物的T2D患者，这种正相关性在敏感性分析中持续存在。在女性中，T2D与CRC风险呈正相关，但无统计学意义（HR为1.17; 95％CI为0.98-1.39）。

由此可见，该研究的结果支持T2D与男性患CRC的风险中度相关; 在女性中观察到较弱的，但无显著性的正相关。

原始出处：

Yanan Ma,et al. Type 2 diabetes and risk of colorectal cancer in two large U.S. prospective cohorts.British Journal of Cancer. 2018. https://www.nature.com/articles/s41416-018-0314-4

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2019-06-22 lfyang

#结直肠癌风险#

77 0
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2019-10-01 sjq027

#癌风险#

81 0
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2018-11-10 一个字-牛

学习了谢谢分享

105 0
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2018-11-10 crystal0564

#结直肠#

100 0
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2018-11-10 1237db7em74暂无昵称

学习了，非常有用

134 0
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2018-11-09 124586e8m31暂无昵称

学习了

94 0
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2018-11-09 misszhang

谢谢MedSci提供最新的资讯

126 0
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2018-11-08 王秀

学习了，涨知识了！

88 0
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2018-11-08 天地飞扬

了解一下，谢谢分享！

98 0

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