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Neurology:无症状大脑中动脉狭窄闭塞,高分辨MRI显示深部微小侧枝流空

2016-06-29 phylis 译 MedSci原创

目的:在这项研究中,研究者旨在探讨高分辨率MRI(HRMRI)下,狭窄闭塞大脑中动脉(MCA)患者深部微小侧枝流空(DTFV)的发病率及临床相关性。方法:研究者回顾性分析477例MCA狭窄闭塞的患者的临床资料和HRMRI。DTFV的存在和分布,定义为HRMRI至少2个连续的T2加权图像,观察到MCA周围3个或更多的流动空隙。分析DTFV与狭窄程度(轻度<50%,中度50%~70%,严重70% -

目的:在这项研究中,研究者旨在探讨高分辨率MRI(HRMRI)下,狭窄闭塞大脑中动脉(MCA)患者深部微小侧枝流空(DTFV)的发病率及临床相关性。

方法:研究者回顾性分析477例MCA狭窄闭塞的患者的临床资料和HRMRI。DTFV的存在和分布,定义为HRMRI至少2个连续的T2加权图像,观察到MCA周围3个或更多的流动空隙。分析DTFV与狭窄程度(轻度<50%,中度50%~70%,严重70% - 99%及阻塞)和梗死的关系。研究者比较与DTFV患者和102例烟雾病患者HRMRI结果,明确DTFV和烟雾病的差异。

结果:MCA轻度狭窄,中度狭窄,重度狭窄及闭塞的患者,DTFV的发生率分别为1.4%,12.8%,40.6%,50.7%。112例DTFV患者中,57(50.9%)有4个象限(上,下,背和腹侧)MCA的涉及。DTFV在无症状患者中比严重狭窄(49.3% vs 30.9%)和闭塞(68% vs 41.7%)的患者更常见。58例(56.9%)烟雾病患者基底节区出现侧枝流空,但在DTFV中未发现。

结论:DTFV常见于重度狭窄闭塞性大脑中动脉动脉疾病,尤其是无症状的患者。研究者推测,DTFV是由于慢性脑缺血所致的新血管网形成。

原始出处:

Xu YY, Li ML, et al. Non-moyamoya vessel network formation along steno-occlusive middle cerebral artery. Neurology. 2016 May 24.


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    2017-04-07 yinhl1978
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    2016-11-02 lsndxfj
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    2016-10-11 ylzr123

    好文,值得推荐。

    0

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