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Sci tranl med:用GCase小分子调节剂(S-181)治疗帕金森病

2019-10-23 QQY 梅斯原创

编码溶酶体β-葡糖脑苷脂酶(GCase)的GBA1基因突变是帕金森病(PD)的最常见的风险因素。野生型GCase活性减弱可能会促进PD的病理进展,激活野生型GCase或可成为PD的治疗方法。GCase已被确定为PD的潜在治疗靶点,目前的研究重点是将突变型GCase转移到溶酶体的化学伴侣。但几种与GBA1相关的PDs类型以及与LRRK2、DJ-1和PARKIN突变相关的PD,野生型GCase激活,提

编码溶酶体β-葡糖脑苷脂酶(GCase)的GBA1基因突变是帕金森病(PD)的最常见的风险因素。野生型GCase活性减弱可能会促进PD的病理进展,激活野生型GCase或可成为PD的治疗方法。GCase已被确定为PD的潜在治疗靶点,目前的研究重点是将突变型GCase转移到溶酶体的化学伴侣。

但几种与GBA1相关的PDs类型以及与LRRK2、DJ-1和PARKIN突变相关的PD,野生型GCase激活,提示存在替代途径。Burbulla等人合成了一种新的GCase小分子调节剂,S-181,可增强散发性PD患者来源的iPSC来源的多巴胺神经元的野生型GCase活性,也可增强携带GBA1 84GG突变或LRRK2、DJ-1或PARKIN基因突变的GCase活性降低的患者的GCase活性。用S-181治疗这些PD患者iPSC来源的多巴胺神经元,可修复其部分溶酶体功能,减少氧化多巴胺,葡糖神经酰胺和α-突触核蛋白的积累。

此外,S-181治疗携带GBA1基因D409V杂合突变的小鼠(Gba1D409V/+)可激活野生型GCase,进而减少小鼠脑组织中的GCase脂质底物和α-突触核蛋白。

本研究表明通过小分子调节剂激活野生型GCase有望成为治疗表现为GCase活性减弱的家族性和散发性PD的新疗法。

原始出处:

Lena F. Burbulla, et al.A modulator of wild-type glucocerebrosidase improves pathogenic phenotypes in dopaminergic neuronal models of Parkinson’s disease.Science Translational Medicine  16 Oct 2019:Vol. 11, Issue 514, eaau6870. DOI: 10.1126/scitranslmed.aau6870

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    2020-05-06 charl1234567
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    2020-06-01 bsmagic9140
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    2019-11-04 aids220
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    2019-11-05 宋威
  5. [GetPortalCommentsPageByObjectIdResponse(id=2027964, encodeId=bac2202e964bb, content=<a href='/topic/show?id=7c9a41324e' target=_blank style='color:#2F92EE;'>#case#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4132, encryptionId=7c9a41324e, topicName=case)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62a7397, createdName=charl1234567, createdTime=Wed May 06 10:29:00 CST 2020, time=2020-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657239, encodeId=719f165e23971, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Mon Jun 01 09:29:00 CST 2020, time=2020-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634214, encodeId=25f81634214ed, content=<a href='/topic/show?id=2d61e8804c' target=_blank style='color:#2F92EE;'>#GCA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7880, encryptionId=2d61e8804c, topicName=GCA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=49d122117300, createdName=aids220, createdTime=Mon Nov 04 08:29:00 CST 2019, time=2019-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1914696, encodeId=5284191469685, content=<a href='/topic/show?id=84d7469559b' target=_blank style='color:#2F92EE;'>#小分子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46955, encryptionId=84d7469559b, topicName=小分子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6105386, createdName=宋威, createdTime=Tue Nov 05 02:29:00 CST 2019, time=2019-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1793526, encodeId=f84c1e93526fb, content=<a href='/topic/show?id=94aa15e8666' target=_blank style='color:#2F92EE;'>#S-181#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15786, encryptionId=94aa15e8666, topicName=S-181)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Wed Jun 03 23:29:00 CST 2020, time=2020-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477877, encodeId=a2be14e787735, content=<a href='/topic/show?id=944315e85c0' target=_blank style='color:#2F92EE;'>#S-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15785, encryptionId=944315e85c0, topicName=S-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a6477383481, createdName=ms3117646317107274, createdTime=Fri Oct 25 09:29:00 CST 2019, time=2019-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610048, encodeId=4a391610048db, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Oct 25 09:29:00 CST 2019, time=2019-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624939, encodeId=c9471624939eb, content=<a href='/topic/show?id=0333412062' target=_blank style='color:#2F92EE;'>#Cas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4120, encryptionId=0333412062, topicName=Cas)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=411420689333, createdName=yaanren, createdTime=Fri Oct 25 09:29:00 CST 2019, time=2019-10-25, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2027964, encodeId=bac2202e964bb, content=<a href='/topic/show?id=7c9a41324e' target=_blank style='color:#2F92EE;'>#case#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4132, encryptionId=7c9a41324e, topicName=case)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62a7397, createdName=charl1234567, createdTime=Wed May 06 10:29:00 CST 2020, time=2020-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657239, encodeId=719f165e23971, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Mon Jun 01 09:29:00 CST 2020, time=2020-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634214, encodeId=25f81634214ed, content=<a href='/topic/show?id=2d61e8804c' target=_blank style='color:#2F92EE;'>#GCA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7880, encryptionId=2d61e8804c, topicName=GCA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=49d122117300, createdName=aids220, createdTime=Mon Nov 04 08:29:00 CST 2019, time=2019-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1914696, encodeId=5284191469685, content=<a href='/topic/show?id=84d7469559b' target=_blank style='color:#2F92EE;'>#小分子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46955, encryptionId=84d7469559b, topicName=小分子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6105386, createdName=宋威, createdTime=Tue Nov 05 02:29:00 CST 2019, time=2019-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1793526, encodeId=f84c1e93526fb, content=<a href='/topic/show?id=94aa15e8666' target=_blank style='color:#2F92EE;'>#S-181#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15786, encryptionId=94aa15e8666, topicName=S-181)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Wed Jun 03 23:29:00 CST 2020, time=2020-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477877, encodeId=a2be14e787735, content=<a href='/topic/show?id=944315e85c0' target=_blank style='color:#2F92EE;'>#S-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15785, encryptionId=944315e85c0, topicName=S-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a6477383481, createdName=ms3117646317107274, createdTime=Fri Oct 25 09:29:00 CST 2019, time=2019-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610048, encodeId=4a391610048db, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Oct 25 09:29:00 CST 2019, time=2019-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624939, encodeId=c9471624939eb, content=<a href='/topic/show?id=0333412062' target=_blank style='color:#2F92EE;'>#Cas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4120, encryptionId=0333412062, topicName=Cas)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=411420689333, createdName=yaanren, createdTime=Fri Oct 25 09:29:00 CST 2019, time=2019-10-25, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=2027964, encodeId=bac2202e964bb, content=<a href='/topic/show?id=7c9a41324e' target=_blank style='color:#2F92EE;'>#case#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4132, encryptionId=7c9a41324e, topicName=case)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62a7397, createdName=charl1234567, createdTime=Wed May 06 10:29:00 CST 2020, time=2020-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657239, encodeId=719f165e23971, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Mon Jun 01 09:29:00 CST 2020, time=2020-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634214, encodeId=25f81634214ed, content=<a href='/topic/show?id=2d61e8804c' target=_blank style='color:#2F92EE;'>#GCA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7880, encryptionId=2d61e8804c, topicName=GCA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=49d122117300, createdName=aids220, createdTime=Mon Nov 04 08:29:00 CST 2019, time=2019-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1914696, encodeId=5284191469685, content=<a href='/topic/show?id=84d7469559b' target=_blank style='color:#2F92EE;'>#小分子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46955, encryptionId=84d7469559b, topicName=小分子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6105386, createdName=宋威, createdTime=Tue Nov 05 02:29:00 CST 2019, time=2019-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1793526, encodeId=f84c1e93526fb, content=<a href='/topic/show?id=94aa15e8666' target=_blank style='color:#2F92EE;'>#S-181#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15786, encryptionId=94aa15e8666, topicName=S-181)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Wed Jun 03 23:29:00 CST 2020, time=2020-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477877, encodeId=a2be14e787735, content=<a href='/topic/show?id=944315e85c0' target=_blank style='color:#2F92EE;'>#S-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15785, encryptionId=944315e85c0, topicName=S-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a6477383481, createdName=ms3117646317107274, createdTime=Fri Oct 25 09:29:00 CST 2019, time=2019-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610048, encodeId=4a391610048db, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Oct 25 09:29:00 CST 2019, time=2019-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624939, encodeId=c9471624939eb, content=<a href='/topic/show?id=0333412062' target=_blank style='color:#2F92EE;'>#Cas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4120, encryptionId=0333412062, topicName=Cas)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=411420689333, createdName=yaanren, createdTime=Fri Oct 25 09:29:00 CST 2019, time=2019-10-25, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=2027964, encodeId=bac2202e964bb, content=<a href='/topic/show?id=7c9a41324e' target=_blank style='color:#2F92EE;'>#case#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4132, encryptionId=7c9a41324e, topicName=case)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62a7397, createdName=charl1234567, createdTime=Wed May 06 10:29:00 CST 2020, time=2020-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657239, encodeId=719f165e23971, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Mon Jun 01 09:29:00 CST 2020, time=2020-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634214, encodeId=25f81634214ed, content=<a href='/topic/show?id=2d61e8804c' target=_blank style='color:#2F92EE;'>#GCA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7880, encryptionId=2d61e8804c, topicName=GCA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=49d122117300, createdName=aids220, createdTime=Mon Nov 04 08:29:00 CST 2019, time=2019-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1914696, encodeId=5284191469685, content=<a href='/topic/show?id=84d7469559b' target=_blank style='color:#2F92EE;'>#小分子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46955, encryptionId=84d7469559b, topicName=小分子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6105386, createdName=宋威, createdTime=Tue Nov 05 02:29:00 CST 2019, time=2019-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1793526, encodeId=f84c1e93526fb, content=<a href='/topic/show?id=94aa15e8666' target=_blank style='color:#2F92EE;'>#S-181#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15786, encryptionId=94aa15e8666, topicName=S-181)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Wed Jun 03 23:29:00 CST 2020, time=2020-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477877, encodeId=a2be14e787735, content=<a href='/topic/show?id=944315e85c0' target=_blank style='color:#2F92EE;'>#S-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15785, encryptionId=944315e85c0, topicName=S-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a6477383481, createdName=ms3117646317107274, createdTime=Fri Oct 25 09:29:00 CST 2019, time=2019-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610048, encodeId=4a391610048db, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Oct 25 09:29:00 CST 2019, time=2019-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624939, encodeId=c9471624939eb, content=<a href='/topic/show?id=0333412062' target=_blank style='color:#2F92EE;'>#Cas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4120, encryptionId=0333412062, topicName=Cas)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=411420689333, createdName=yaanren, createdTime=Fri Oct 25 09:29:00 CST 2019, time=2019-10-25, status=1, ipAttribution=)]
    2019-10-25 yaanren

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由此可见,在这项基于人群的研究中,研究人员发现OH是一种非常常见但未治疗的并发症。早期PD与疾病特异性症状和药物治疗相关。该研究的结果表明临床医生应该更积极地评估和控制PD患者的OH。

Radiology: 高分辨扩散加权MRI在帕金森病诊断中的价值

背景:帕金森病(PD)运动症状表现为偏侧性的,提示在黑质(SN)不对称性神经元缺失。扩散MRI 有助于确定黑质组织微观结构改变来确定症状不对称性。

NEJM:橄榄球运动员的神经退行性疾病死亡风险增加

在这项回顾性流行病学分析中,前苏格兰职业橄榄球运动员的神经退行性疾病死亡率高于对照组,其他常见疾病死亡率低于对照组

罗蔚锋教授:应用A肉型肉毒毒素治疗帕金森病抑郁的基础与临床研究| NCN2019

帕金森病(PD)是老年人中常见的神经系统退行性疾病,除了经典的运动症状外,一些非运动症状也给患者带来极大的痛苦,如嗅觉减退、睡眠障碍及抑郁等。抑郁是PD常伴发的精神障碍,发病率平均约40%,PD合并抑郁症状的患者常有认知功能损害、运动功能及日常生活能力的下降,严重影响了患者的生活质量,导致致残率及病死率增加。治疗PD的方法有药物治疗和非药物治疗,非药物疗法中主要有重复经磁刺激、认知行为疗法、电休克

2019 加拿大指南:帕金森病

帕金森病是一种慢性进展性疾病,第一版加拿大帕金森病指南于2012年发布,本文是对2012年版指南的更新,目的是加强加拿大帕金森病的护理。指南主要建议内容涉及帕金森病的诊断和进展,治疗,姑息治疗等。

Neurology:NfL是帕金森病严重程度和进展的生物标志物

由此可见,血浆NfL水平与PD患者运动和认知功能的疾病严重程度和进展相关。

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