J Periodontal Res：富血小板纤维蛋白/阿司匹林复合物促进大鼠牙周缺损的牙槽骨再生

2018-03-31 MedSci MedSci原创

本实验研究了阿司匹林对局部缺损的疗效和结果以及富含血小板的纤维蛋白（PRF）在牙周缺损中的应用。确定PRF /阿司匹林复合物是否是合适的携带缓释阿司匹林/水杨酸载体和递送系统以促进牙周骨再生。

本实验研究了阿司匹林对局部缺损的疗效和结果以及富含血小板的纤维蛋白（PRF）在牙周缺损中的应用。确定PRF /阿司匹林复合物是否是合适的携带缓释阿司匹林/水杨酸载体和递送系统以促进牙周骨再生。

制备PRF和PRF /阿司匹林复合物。计算37℃时从PRF /阿司匹林复合物释放的阿司匹林/水杨酸的浓度。用PRF或PRF /阿司匹林复合物凝胶在六孔板上培养牙周韧带间充质细胞以分析增殖和迁移。将15只大鼠随机分为3组：不处理，PRF或PRF /阿司匹林复合物，将上颌第1磨牙颊侧近中根与前颊侧远中根之间的牙槽骨移除。移植后12周，使用2D / 3D显微计算机断层扫描和组织形态计量技术进行定量分析。

结果：PRF /阿司匹林复合物提供了缓释阿司匹林/水杨酸。移植后4小时出现峰值浓度并在37℃下持续48小时；释放的阿司匹林/水杨酸的总浓度分别为83.5mg / mL。持续释放促进牙周膜间充质细胞的增殖和迁移。微型计算机断层扫描和组织学数据显示，PRF和PRF /阿司匹林复合物均可增强牙周骨形成（P <0.05）。此外，PRF /阿司匹林复合物组的新骨形成比PRF组大2倍。

结论：阿司匹林/水杨酸可从PRF /阿司匹林复合物中缓释，抑制炎症反应，改善间充质细胞的功能。这些数据可能为牙周骨修复提供了一种新的安全和简便的临床治疗策略。

原始出处：

J. Du， et al. Platelet‐rich fibrin/aspirin complex promotes alveolar bone regeneration in periodontal defect in rats. Journal of Periodontal Research. 2018 February. doi：10.1111/jre.12485

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2018-11-22 12498f1em08(暂无昵称)

#牙槽骨再生#

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2018-05-17 爆笑小医

#富血小板纤维蛋白#

67 0
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2019-03-15 mei540

#牙槽骨#

59 0
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2018-07-27 axin009

#纤维蛋白#

55 0
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2018-06-07 yang0210

#复合物#

61 0
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2018-10-02 feather89

#PE#

70 0
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2018-04-02 liuyong2982

#牙周#

51 0
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2018-04-02 lsj630

#骨再生#

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J Periodontal Res：富血小板纤维蛋白/阿司匹林复合物促进大鼠牙周缺损的牙槽骨再生

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