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Eur Respir J：血管紧张素转换酶2在肺动脉高压中的潜在治疗作用！

2018-06-21 xing.T MedSci原创

PAHACE2治疗作用
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由此可见，PAH患者的特征包含ACE2活性降低。ACE2在一项试验性研究中确定具有很好的耐受性，其与改善的肺血流动力学和降低的氧化剂和炎症介质标记物有关。靶向这一途径对PAH患者可能是有益的。

肺动脉高压（PAH）是一种无法治愈的致命疾病。血管紧张素转换酶2（ACE2）可将血管紧张素II（AngII）转换成血管紧张素-（1-7），通过与Mas受体（Mas1）结合可以使其激活改善啮齿类动物PAH模型。重组人（rh）ACE2在人PAH中的作用尚不清楚。近日，呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章，研究人员的目的是确定rhACE2在PAH中的作用。

研究人员通过猪的肺动脉确定了Mas1活化的分子效应，测量了PAH患者AngII/ANG（1-7）的水平，并进行了单次输注rhACE2（GSK2586181，0.2或0.4mg·kg-1）的IIa期、开放标签的初步研究。

超氧化物歧化酶2（SOD2）和炎性基因表达被作为Mas1活化的标志物。在确认PAH患者血浆中ACE2活性降低后，五例患者进入该试验。GSK2586891耐受性良好，心输出量和肺血管阻力显著改善。GSK2586181输注与血浆炎症标记物在2～4小时内降低相关联，并在2周时增加血浆中SOD2蛋白水平。

由此可见，PAH患者的特征包含ACE2活性降低。ACE2在一项试验性研究中确定具有很好的耐受性，其与改善的肺血流动力学和降低的氧化剂和炎症介质标记物有关。靶向这一途径对PAH患者可能是有益的。

原始出处：

Anna R. Hemnes,et al. A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension.Eur Respir J. 2018. http://erj.ersjournals.com/content/51/6/1702638

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    2019-02-09 jklm09

    #动脉高压#

    0

  2. 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    2018-06-25 王秀

    学习了.涨知识了!

    0

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    2018-06-23 xiongliangxl

    #血管紧张素#

    0

  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Thu Jun 21 23:13:39 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325943, encodeId=bd8c325943bf, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Thu Jun 21 23:02:27 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325934, encodeId=ea5432593414, content=好文.值得点赞!认真学习.应用于实践!谢谢分享给广大同好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Jun 21 22:25:53 CST 2018, time=2018-06-21, status=1, ipAttribution=)]
    2018-06-22 张新亮1853311252142e2fm

    好文献学习了

    0

  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Thu Jun 21 23:13:39 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325943, encodeId=bd8c325943bf, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Thu Jun 21 23:02:27 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325934, encodeId=ea5432593414, content=好文.值得点赞!认真学习.应用于实践!谢谢分享给广大同好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Jun 21 22:25:53 CST 2018, time=2018-06-21, status=1, ipAttribution=)]
    2018-06-22 飛歌

    厉害了我的哥

    0

  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Jun 21 22:25:53 CST 2018, time=2018-06-21, status=1, ipAttribution=)]
    2018-06-21 明天jing

    肺动脉高压表面是罕见病，事实上临床上并不少见，治疗药物虽然有一些，但是整体仍然不理解，可能未来需要采用综合治疗措施。

    0

  7. 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createdBy=f0620, createdName=明天jing, createdTime=Thu Jun 21 23:57:00 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325957, encodeId=c53732595eec, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Thu Jun 21 23:36:45 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325948, encodeId=29ff32594863, content=^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Thu Jun 21 23:13:39 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325943, encodeId=bd8c325943bf, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Thu Jun 21 23:02:27 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325934, encodeId=ea5432593414, content=好文.值得点赞!认真学习.应用于实践!谢谢分享给广大同好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Jun 21 22:25:53 CST 2018, time=2018-06-21, status=1, ipAttribution=)]
    2018-06-21 天地飞扬

    了解一下.谢谢分享!

    0

  8. 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createdName=王秀, createdTime=Mon Jun 25 13:38:31 CST 2018, time=2018-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1589309, encodeId=43a21589309e6, content=<a href='/topic/show?id=fb0389e4373' target=_blank style='color:#2F92EE;'>#血管紧张素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89743, encryptionId=fb0389e4373, topicName=血管紧张素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5ce517702394, createdName=xiongliangxl, createdTime=Sat Jun 23 11:57:00 CST 2018, time=2018-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326038, encodeId=7977326038e6, content=好文献学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, 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createdBy=f0620, createdName=明天jing, createdTime=Thu Jun 21 23:57:00 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325957, encodeId=c53732595eec, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Thu Jun 21 23:36:45 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325948, encodeId=29ff32594863, content=^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Thu Jun 21 23:13:39 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325943, encodeId=bd8c325943bf, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Thu Jun 21 23:02:27 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325934, encodeId=ea5432593414, content=好文.值得点赞!认真学习.应用于实践!谢谢分享给广大同好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Jun 21 22:25:53 CST 2018, time=2018-06-21, status=1, ipAttribution=)]
    2018-06-21 wqkm

    ^_^^_^^_^

    0

  9. 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createdName=张新亮1853311252142e2fm, createdTime=Fri Jun 22 07:14:40 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325981, encodeId=759e32598191, content=厉害了我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Fri Jun 22 00:09:10 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050805, encodeId=10d810508055e, content=肺动脉高压表面是罕见病，事实上临床上并不少见，治疗药物虽然有一些，但是整体仍然不理解，可能未来需要采用综合治疗措施。, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Thu Jun 21 23:57:00 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325957, encodeId=c53732595eec, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Thu Jun 21 23:36:45 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325948, encodeId=29ff32594863, content=^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Thu Jun 21 23:13:39 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325943, encodeId=bd8c325943bf, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Thu Jun 21 23:02:27 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325934, encodeId=ea5432593414, content=好文.值得点赞!认真学习.应用于实践!谢谢分享给广大同好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Jun 21 22:25:53 CST 2018, time=2018-06-21, status=1, ipAttribution=)]
    2018-06-21 1e1b8538m79(暂无匿称)

    不错的文章值得拥有哦

    0

  10. 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createdName=王秀, createdTime=Mon Jun 25 13:38:31 CST 2018, time=2018-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1589309, encodeId=43a21589309e6, content=<a href='/topic/show?id=fb0389e4373' target=_blank style='color:#2F92EE;'>#血管紧张素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89743, encryptionId=fb0389e4373, topicName=血管紧张素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5ce517702394, createdName=xiongliangxl, createdTime=Sat Jun 23 11:57:00 CST 2018, time=2018-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326038, encodeId=7977326038e6, content=好文献学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Fri Jun 22 07:14:40 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325981, encodeId=759e32598191, content=厉害了我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Fri Jun 22 00:09:10 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050805, encodeId=10d810508055e, content=肺动脉高压表面是罕见病，事实上临床上并不少见，治疗药物虽然有一些，但是整体仍然不理解，可能未来需要采用综合治疗措施。, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Thu Jun 21 23:57:00 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325957, encodeId=c53732595eec, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Thu Jun 21 23:36:45 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325948, encodeId=29ff32594863, content=^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Thu Jun 21 23:13:39 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325943, encodeId=bd8c325943bf, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Thu Jun 21 23:02:27 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325934, encodeId=ea5432593414, content=好文.值得点赞!认真学习.应用于实践!谢谢分享给广大同好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Jun 21 22:25:53 CST 2018, time=2018-06-21, status=1, ipAttribution=)]
    2018-06-21 虈亣靌

    好文.值得点赞!认真学习.应用于实践!谢谢分享给广大同好!

    0

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JAHA：波强度分析为肺动脉高压和慢性血栓栓塞性肺动脉高压提供了新视角！

PH患者的肺动脉内波反射增强与疾病严重程度无关，提示血管阻抗不匹配发生在肺血管病的早期。相比于CTEPH患者，PAH患者较低的波功率分数表明这两种疾病之间的内在或外在心室负荷存在差异。

SCI REP：心血管疾病的早期标志物与多环芳香烃的职业暴露有关！

由此可见，烟囱清洁工PAH暴露导致心血管疾病的危险标志物水平升高。这些研究结果强调有必要减少PAH的职业暴露。

Eur Heart J-Card Img：静息时右心室功能与PAH患者运动表现相关！

由此可见，在PAH患者中，由FAC或RVLS评估的静息RV功能与患者运动表现相关，因此对PAH患者的非侵入性评估具有重大贡献。在CTEPH患者中未发现这种关联，提示静息右心室功能与运动表现之间无关，无法将运动指标作为CTEPH患者的预后标记和临床/研究终点。

Chest：基线和系列脑利钠肽水平预测肺动脉高压患者5年总生存率！

由此可见，基线BNP阈值为340pg/mL时可以很好地预测PAH患者的5年生存期。受试者招募1年后BNP水平降低与死亡风险降低有关，1年后BNP水平升高与死亡风险增加相关，这些结果支持了BNP作为PAH患者生存期的替代指标。

Heart：成年先天性心脏病和肺动脉高压患者心律失常状况！

由此可见，心律失常在PAH-CHD患者中很常见，并且与长期不良结局相关，即使在专科中心进行治疗。

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