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Cell:全新类鸦片止痛药有望问世,效果堪比吗啡,芬太尼,却没有成瘾风险!

2017-11-17 Heather_z727 来宝网

来自斯克里普斯研究所的科学家们开发出新的阿片类止痛药,这种新型止痛药减轻疼痛的能力与吗啡相当,但是药物过量的副作用和风险却大大降低。

新止痛药减少药物过量的风险】来自斯克里普斯研究所的科学家们开发出新的阿片类止痛药,这种新型止痛药减轻疼痛的能力与吗啡相当,但是药物过量的副作用和风险却大大降低。

今天发表在《细胞》杂志上文章描述了一个方法,可以安全使用阿片类止痛药。根据美国疾病控制和预防中心的数据,每天有91人死于阿片类过量,其中包括海洛因,芬太尼等减缓疼痛的药物,也最终停止了人的呼吸。

在此次研究中,研究人员发现一系列的化合物可以达到止痛的效果,却不影响人的呼吸,研究建立在两个几十年的研究中,研究人员长期质疑止痛通路,G蛋白通路,它可以链接的呼吸抑制通路,其中一个问题一直困扰着研究人员,那就是如何分离通道。

在这项研究中,研究人员开发出新的潜在药物分子,然后他们调整化学结构,系统地变化蛋白质信号之间的通路,在过去的六年里,研究人员已经开发了超过500种化合物,他们发现60多信号之间的偏差,接着,他们锁定6个化合物,确定他们在治疗小鼠镇痛和呼吸抑制中的作用。

研究人员发现,这些新的化合物的确可能进入大脑,而所有的化合物都是有效的,所以止痛效果不会低于吗啡,但是与此同时,新的化合物却不太能够诱发小鼠的呼吸抑制。

简而言之,这种新的化合物大大降低了阿片类药物药物过量致死的风险。

原始出处:

Cullen L. Schmid, Nicole M. Kennedy, Nicolette C. Ross, et al. Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics. Cell, 2017.

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    2018-01-05 维他命
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    2017-11-19 1e127dd4m40(暂无匿称)

    期待

    0

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    2017-11-19 showtest
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    2017-11-19 xue8602
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    2017-11-19 zhangxingru

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