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Gastroenterology:吉三代联合利巴韦林可提高HCV III型感染人群治愈率

2018-07-02 zhangfan MedSci原创

研究认为,Epclusa联合利巴韦林可提高HCV III型感染伴肝硬化人群的治愈率

之前的III期临床以及真实世界研究中,HCV III型感染伴肝硬化人群接受Epclusa(sofosbuvir 和velpatasvir)后12周实现持续病毒学应答率(SVR12)低于非肝硬化人群。近日研究人员考察了Epclusa联合利巴韦林治疗对这部分患者的效果。

204名HCV III型感染患者,平均年龄51,随机接受Epclusa(n=101)或Epclusa联合利巴韦林(n=103),持续12周,主要终点为SVR12。

Epclusa治疗组SVR12率为91%,而联合利巴韦林组为96%。Epclusa组,部分NS5A基线耐药(RAS)患者,SVR12率仅为84%,未耐药人群为96%。对于Epclusa联合利巴韦林组,RAS的影响不显著,耐药人群SVR12为96%,非耐药人群为99%。最常见的不良事件为贫血、头痛以及失眠。

研究认为,Epclusa联合利巴韦林可提高HCV III型感染伴肝硬化人群的治愈率。

原始出处:


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    2018-12-05 juliusluan78
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    2019-01-19 许安
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    2018-09-01 cenghis
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    2018-07-04 ymljack
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    2018-07-03 1ddf0692m34(暂无匿称)

    学习了.谢谢分享

    0

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SVR24的肝硬度可能能够反映接受DAA治疗的患者的肝纤维化情况。另外,脂肪肝减少的同时,肝脂肪变性也减少了。

BMC Infect Dis:乙型肝炎和丙型肝炎患者死亡率趋势:以人口为基础的联系研究,1993-2012

HBV相关的肝脏死亡率的降低和负担的稳定,表明了抗病毒治疗效果的影响。与此相反,针对HCV的干扰素治疗方案对肝脏相关死亡率、个体水平风险和人口水平负担的影响是有限的。

J Gastroenterol Hepatol:HCV、HBV双感染阻断了血小板计数的恢复,尤其是在晚期肝纤维化患者中

丙型肝炎病毒根除后血小板计数恢复。HBV双感染阻断了PLT计数的恢复,尤其是在晚期肝纤维化患者中。

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