Baidu
map

Anaesthesist:2%七氟烷反复吸入会导致青年大鼠神经毒性和认知功能障碍

2018-01-25 周倩 “罂粟花”微信号

七氟醚是儿科麻醉中使用最广泛的吸入麻醉药之一。大量研究表明,在新生儿期七氟醚高浓度麻醉或持续时间较长的反复治疗可诱发神经细胞凋亡和长期学习障碍。在临床实践中,我们观察到一部分患者在七氟醚麻醉下从出生到青春期不止一次进行了小手术。因此,本研究旨在探讨七氟醚浓度为2%(七氟烷临床相关用量)持续1 h(持续时间短)在新生儿期是否可诱导接受七氟醚(2%,1 h)的青春期大鼠神经细胞凋亡和神经认知功能障碍。

背景与目的:七氟醚是儿科麻醉中使用最广泛的吸入麻醉药之一。大量研究表明,在新生儿期七氟醚高浓度麻醉或持续时间较长的反复治疗可诱发神经细胞凋亡和长期学习障碍。在临床实践中,我们观察到一部分患者在七氟醚麻醉下从出生到青春期不止一次进行了小手术。因此,本研究旨在探讨七氟醚浓度为2%(七氟烷临床相关用量)持续1 h(持续时间短)在新生儿期是否可诱导接受七氟醚(2%,1 h)的青春期大鼠神经细胞凋亡和神经认知功能障碍。

方  法:第一组:出生后第7天的新生大鼠(PND-7)在受控条件下用氧气处理,然后升至PND-60。第二组:PND-7大鼠用2%七氟烷处理1小时,然后饲养至PND-60。第三组:PND-60大鼠用2%七氟醚处理1小时,第四组PND-7大鼠用2%七氟醚处理1小时,然后再用2%七氟醚在PND-60再麻醉1小时。 Western blot检测海马齿状回(DG)中caspase-3,Bax和Bcl-2的表达。用NeuN / caspase-3双免疫荧光染色评估海马DG中的神经凋亡。空间参考记忆由Morris水迷宫测试测试。

结  果:七氟醚(2%,1 h)对PND-7大鼠和PND-60大鼠未引起明显的海马神经细胞凋亡;它们在海马依赖的空间记忆中的表现没有显着受损;然而,第四组大鼠在Morris水迷宫实验中表现不佳,第四组神经细胞凋亡显着增加。

结  论:我们的研究结果表明,七氟醚可以诱导产后期反复七氟醚(2%,1 h)的青春期大鼠的神经细胞凋亡和认知功能障碍。这些研究结果将促进进一步的研究,以调查重复七氟烷暴露对中枢神经系统的发展和学习和记忆功能,以及体内和体外的潜在机制的影响。

原始出处:


版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (6)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1633446, encodeId=cb671633446bd, content=<a href='/topic/show?id=377824e1c0' target=_blank style='color:#2F92EE;'>#ANA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2471, encryptionId=377824e1c0, topicName=ANA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=434d22047430, createdName=AspirantSuo, createdTime=Sun Dec 16 17:05:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2051035, encodeId=f61e2051035aa, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sun Dec 09 17:05:00 CST 2018, time=2018-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1398940, encodeId=815a1398940bd, content=<a href='/topic/show?id=628a1950815' target=_blank style='color:#2F92EE;'>#七氟烷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19508, encryptionId=628a1950815, topicName=七氟烷)], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/88718775CFFF6B17C67C7488678286A2/100, createdBy=dc522178171, createdName=循证小兵, createdTime=Sat Jan 27 05:05:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421142, encodeId=b5931421142c1, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Sat Jan 27 05:05:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484106, encodeId=48481484106bd, content=<a href='/topic/show?id=81c2e4343a9' target=_blank style='color:#2F92EE;'>#神经毒性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74343, encryptionId=81c2e4343a9, topicName=神经毒性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=42127951174, createdName=12498cf9m37(暂无昵称), createdTime=Sat Jan 27 05:05:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588304, encodeId=133e158830404, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Sat Jan 27 05:05:00 CST 2018, time=2018-01-27, status=1, ipAttribution=)]
    2018-12-16 AspirantSuo
  2. [GetPortalCommentsPageByObjectIdResponse(id=1633446, encodeId=cb671633446bd, content=<a href='/topic/show?id=377824e1c0' target=_blank style='color:#2F92EE;'>#ANA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2471, encryptionId=377824e1c0, topicName=ANA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=434d22047430, createdName=AspirantSuo, createdTime=Sun Dec 16 17:05:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2051035, encodeId=f61e2051035aa, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sun Dec 09 17:05:00 CST 2018, time=2018-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1398940, encodeId=815a1398940bd, content=<a href='/topic/show?id=628a1950815' target=_blank style='color:#2F92EE;'>#七氟烷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19508, encryptionId=628a1950815, topicName=七氟烷)], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/88718775CFFF6B17C67C7488678286A2/100, createdBy=dc522178171, createdName=循证小兵, createdTime=Sat Jan 27 05:05:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421142, encodeId=b5931421142c1, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Sat Jan 27 05:05:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484106, encodeId=48481484106bd, content=<a href='/topic/show?id=81c2e4343a9' target=_blank style='color:#2F92EE;'>#神经毒性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74343, encryptionId=81c2e4343a9, topicName=神经毒性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=42127951174, createdName=12498cf9m37(暂无昵称), createdTime=Sat Jan 27 05:05:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588304, encodeId=133e158830404, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Sat Jan 27 05:05:00 CST 2018, time=2018-01-27, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1633446, encodeId=cb671633446bd, content=<a href='/topic/show?id=377824e1c0' target=_blank style='color:#2F92EE;'>#ANA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2471, encryptionId=377824e1c0, topicName=ANA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=434d22047430, createdName=AspirantSuo, createdTime=Sun Dec 16 17:05:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2051035, encodeId=f61e2051035aa, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sun Dec 09 17:05:00 CST 2018, time=2018-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1398940, encodeId=815a1398940bd, content=<a href='/topic/show?id=628a1950815' target=_blank style='color:#2F92EE;'>#七氟烷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19508, encryptionId=628a1950815, topicName=七氟烷)], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/88718775CFFF6B17C67C7488678286A2/100, createdBy=dc522178171, createdName=循证小兵, createdTime=Sat Jan 27 05:05:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421142, encodeId=b5931421142c1, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Sat Jan 27 05:05:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484106, encodeId=48481484106bd, content=<a href='/topic/show?id=81c2e4343a9' target=_blank style='color:#2F92EE;'>#神经毒性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74343, encryptionId=81c2e4343a9, topicName=神经毒性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=42127951174, createdName=12498cf9m37(暂无昵称), createdTime=Sat Jan 27 05:05:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588304, encodeId=133e158830404, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Sat Jan 27 05:05:00 CST 2018, time=2018-01-27, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1633446, encodeId=cb671633446bd, content=<a href='/topic/show?id=377824e1c0' target=_blank style='color:#2F92EE;'>#ANA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2471, encryptionId=377824e1c0, topicName=ANA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=434d22047430, createdName=AspirantSuo, createdTime=Sun Dec 16 17:05:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2051035, encodeId=f61e2051035aa, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sun Dec 09 17:05:00 CST 2018, time=2018-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1398940, encodeId=815a1398940bd, content=<a href='/topic/show?id=628a1950815' target=_blank style='color:#2F92EE;'>#七氟烷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19508, encryptionId=628a1950815, topicName=七氟烷)], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/88718775CFFF6B17C67C7488678286A2/100, createdBy=dc522178171, createdName=循证小兵, createdTime=Sat Jan 27 05:05:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421142, encodeId=b5931421142c1, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Sat Jan 27 05:05:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484106, encodeId=48481484106bd, content=<a href='/topic/show?id=81c2e4343a9' target=_blank style='color:#2F92EE;'>#神经毒性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74343, encryptionId=81c2e4343a9, topicName=神经毒性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=42127951174, createdName=12498cf9m37(暂无昵称), createdTime=Sat Jan 27 05:05:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588304, encodeId=133e158830404, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Sat Jan 27 05:05:00 CST 2018, time=2018-01-27, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1633446, encodeId=cb671633446bd, content=<a href='/topic/show?id=377824e1c0' target=_blank style='color:#2F92EE;'>#ANA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2471, encryptionId=377824e1c0, topicName=ANA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=434d22047430, createdName=AspirantSuo, createdTime=Sun Dec 16 17:05:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2051035, encodeId=f61e2051035aa, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sun Dec 09 17:05:00 CST 2018, time=2018-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1398940, encodeId=815a1398940bd, content=<a href='/topic/show?id=628a1950815' target=_blank style='color:#2F92EE;'>#七氟烷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19508, encryptionId=628a1950815, topicName=七氟烷)], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/88718775CFFF6B17C67C7488678286A2/100, createdBy=dc522178171, createdName=循证小兵, createdTime=Sat Jan 27 05:05:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421142, encodeId=b5931421142c1, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Sat Jan 27 05:05:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484106, encodeId=48481484106bd, content=<a href='/topic/show?id=81c2e4343a9' target=_blank style='color:#2F92EE;'>#神经毒性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74343, encryptionId=81c2e4343a9, topicName=神经毒性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=42127951174, createdName=12498cf9m37(暂无昵称), createdTime=Sat Jan 27 05:05:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588304, encodeId=133e158830404, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Sat Jan 27 05:05:00 CST 2018, time=2018-01-27, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1633446, encodeId=cb671633446bd, content=<a href='/topic/show?id=377824e1c0' target=_blank style='color:#2F92EE;'>#ANA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2471, encryptionId=377824e1c0, topicName=ANA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=434d22047430, createdName=AspirantSuo, createdTime=Sun Dec 16 17:05:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2051035, encodeId=f61e2051035aa, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sun Dec 09 17:05:00 CST 2018, time=2018-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1398940, encodeId=815a1398940bd, content=<a href='/topic/show?id=628a1950815' target=_blank style='color:#2F92EE;'>#七氟烷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19508, encryptionId=628a1950815, topicName=七氟烷)], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/88718775CFFF6B17C67C7488678286A2/100, createdBy=dc522178171, createdName=循证小兵, createdTime=Sat Jan 27 05:05:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421142, encodeId=b5931421142c1, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Sat Jan 27 05:05:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484106, encodeId=48481484106bd, content=<a href='/topic/show?id=81c2e4343a9' target=_blank style='color:#2F92EE;'>#神经毒性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74343, encryptionId=81c2e4343a9, topicName=神经毒性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=42127951174, createdName=12498cf9m37(暂无昵称), createdTime=Sat Jan 27 05:05:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588304, encodeId=133e158830404, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Sat Jan 27 05:05:00 CST 2018, time=2018-01-27, status=1, ipAttribution=)]
    2018-01-27 skhzy

相关资讯

Eur J Anaesthesiol:小儿七氟醚麻醉苏醒期的临床行为特征和脑电图类型:一项观察研究

很少有研究系统地描述了小儿麻醉苏醒期的临床行为体征、脑电图(EEG)类型和年龄之间的关系。

Lancet Child Adol Health:可乐定预防儿童七氟醚麻醉后的术后躁动

研究认为,可乐定可安全地用于预防男孩七氟醚麻醉后的术后躁动

PLoS One:七氟醚显著延长高血糖患者的QTc间期

QTc间期延长是糖尿病患者的一种严重并发症并增加其死亡率。高血糖抑制延迟整流钾通道电流的快速成分(Ikr)而引起心电图QTc间期的延长。同时七氟醚抑制Ikr 引起QTc间期延长。事实上,尖端扭转型室速也发生在七氟醚麻醉期间糖尿病控制不佳的患者身上。

Mol Med Rep:新生小鼠反复吸入七氟醚抑制浦肯野细胞的信息传递并且通过GABAA受体的ε(艾普西龙)亚基减缓运动神经发育

尽管全身麻醉对小脑信息传递和运动功能的影响尚不清楚,但是全身麻醉还是广泛应用于小儿外科手术。

Anesth Analg:较之异氟醚,七氟醚可很大程度减轻大鼠肺源性急性呼吸窘迫综合征引起的肺损伤

挥发性麻醉药能调节急性呼吸窘迫综合征(ARDS)中的炎症反应。而它们是否因为ARDS病因的不同而呈现出不同作用,目前尚不十分清楚。我们假设体内、体外实验中,七氟醚和异氟醚在肺源性(p)和非肺源性(exp)ARDS对肺损伤的影响中不存在差异。

Life Sci:反复接触七氟醚会损害老年雄性大鼠的学习能力和记忆

危重病患者常需要反复手术干预,因此探讨反复接触麻醉药物对学习和记忆的影响就显得非常重要。七氟醚是一种广泛使用的吸入麻醉剂,对神经系统几乎没有副作用,并能使意识迅速恢复。但七氟醚暴露的长期影响和重复七氟醚暴露后对认知功能的影响却少有文献报道,这与现有的研究相矛盾。

Baidu
map
Baidu
map
Baidu
map