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Allergy:局部过敏性鼻炎患者屋尘螨激发的支气管炎研究

2019-04-06 AlexYang MedSci原创

超过30%的局部过敏性鼻炎(LAR)患者具有自我报道的哮喘支气管症状,但是过敏原接触与支气管症状之间的相关性还未研究。最近,有研究人员调查了是否存在与LAR相对应的支气管病变。研究人员通过临床历史、皮刺测试/血清特异性lgE(slgE)和鼻过敏原激发测试(NAPT)将患者分成LAR、过敏性鼻炎(AR)和非过敏性鼻炎(NAR)表型。总共包括了28名LAR,18名AR和19名NAR以及8名健康对照(H

超过30%的局部过敏性鼻炎(LAR)患者具有自我报道的哮喘支气管症状,但是过敏原接触与支气管症状之间的相关性还未研究。最近,有研究人员调查了是否存在与LAR相对应的支气管病变。

研究人员通过临床历史、皮刺测试/血清特异性lgE(slgE)和鼻过敏原激发测试(NAPT)将患者分成LAR、过敏性鼻炎(AR)和非过敏性鼻炎(NAR)表型。总共包括了28名LAR,18名AR和19名NAR以及8名健康对照(HC)参与者。研究发现,在50%的LAR患者、83.3%的AR患者,57.89%的NAR患者和0%的对照中鉴定出了阳性醋甲胆碱测试(MT)结果。屋尘螨支气管激发试验(BPT-DP)在8名LAR和15名AR患者中为阳性(28% vs 83.3%, P<0.001),而NAR和HC中没有阳性反应。所有的BPT-DP+患者均经历了显著的PC20减少(P=0.016 LAR, P=<0.001 AR)。BPT-DP+患者同样也表现出了嗜酸性粒细胞、单核细胞和ECP的显著减少。

最后,研究人员指出,他们的结果表明了新哮喘表型的出现(局部过敏性哮喘),主要是通过系统性特异反应的缺失和过敏原BPT测试阳性结果来鉴定。

原始出处:

Campo P, Eguiluz-Gracia I, Plaza-Serón MC et al. Bronchial asthma triggered by house dust mites in patients with local allergic rhinitis. Allergy. 18 Mar 2019.

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    2019-04-08 医者仁心5538

    学习了

    0

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    2019-04-08 膀胱癌
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    2019-04-08 chg122

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