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BMJ: 非酒精性脂肪肝与肥胖可以作为胃癌和结直肠癌的独立预测因素

2019-09-13 不详 MedSci原创

已知结直肠癌是非酒精性脂肪肝病(NAFLD)的肝外并发症。然而,NAFLD与肥胖症相关的结直肠癌的相互作用尚不清楚。因此,本项研究旨在探究肥胖和NAFLD是否是胃癌和结直肠癌的危险因素。

背景及目的
已知直肠癌是非酒精性脂肪肝病(NAFLD)的肝外并发症。然而,NAFLD与肥胖症相关的直肠癌的相互作用尚不清楚。因此,本项研究旨在探究肥胖和NAFLD是否是癌和结直肠癌的危险因素。

方法
研究人员使用标准化的腹部超声来诊断患者是否患有NAFLD。同时应用Cox比例风险模型来研究NAFLD以及在基线时是否伴有肥胖对癌以及结直肠癌的影响。年龄,性别,生活方式因素,包括吸烟状态,饮酒和运动,以及糖尿病被用作协变量。

结果
在研究期间共有27944名患者(16454名男性和11490名女性)被纳入本项研究。在2357天的平均观察期间内,48名患者被诊断胃癌(事件发生率为每1000人年0.48),并且有52名患者被诊断结肠直肠癌(事件发生率0.51 / 1000人年)。调整后的胃癌患者NAFLD与肥胖的HR为3.58(95%CI 1.73~7.38,p=0.001),结直肠癌的发生率为2.96(95%CI 1.73~7.38,p=0.003)。

结论
NAFLD与肥胖是成年人胃癌和结直肠癌发生的危险因素。

原始出处:

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    2020-04-15 gaoxiaoe
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J INTERN MED:非酒精性脂肪性肝病增加了发生晚期慢性肾病的风险

由此可见,NAFLD与晚期CKD发生发展风险增加独立相关,表明该人群需要进行肾功能筛查和定期监测。

Dig Liver Dis: 活检证实非酒精性脂肪性肝病患者维生素D水平与维生素D相关基因多态性与肝纤维化有关

维生素D具有良好的抗增殖和抗纤维化特性,但其在非酒精性脂肪性肝病(NAFLD)中的临床应用尚不清楚。本研究旨在阐明维生素D水平,维生素D相关基因的单核苷酸多态性(SNPs)与活检证实的NAFLD患者的疾病组织病理学严重程度之间的关系。

AP&T: 抑郁症与成人中的非酒精性脂肪肝相关

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Hepatology: 酒精摄入对非酒精性脂肪性肝病患者死亡率的影响

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BMJ:慢性腹泻与非酒精性脂肪肝病和肥胖相关疾病的关系

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