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GUT: 酒精和非酒精性脂肪肝均与冠状动脉钙化有关

2019-08-17 不详 MedSci原创

最近的研究表明,酒精性脂肪性肝病(AFLD)和非酒精性脂肪性肝病(NAFLD)可能会对心血管死亡风险产生不同的影响。为了研究AFLD或NAFLD引起的早期肝病是否对早期冠状动脉粥样硬化的风险有相似或不相似的影响,本项研究探究了AFLD与NAFLD和冠状动脉钙(CAC)之间的关系。

背景及目的:
最近的研究表明,酒精性脂肪性肝病(AFLD)和非酒精性脂肪性肝病(NAFLD)可能会对心血管死亡风险产生不同的影响。为了研究AFLD或NAFLD引起的早期肝病是否对早期冠状动脉粥样硬化的风险有相似或不相似的影响,本项研究探究了AFLD与NAFLD和冠状动脉钙(CAC)之间的关系。

方法:
研究人员对行体检的105328名韩国成年人进行了横断面研究。使用CT评估CAC评分,通过超声将每日酒精摄入记录为克/天诊断肝脏脂肪。

结果:
NAFLD和AFLD均与CAC评分呈正相关。NAFLD和AFLD与CAC评分的关联在非肥胖和肥胖个体中相似,没有肥胖的显着相互作用(相互作用的p = 0.088)。在调整胰岛素抵抗和高敏C反应蛋白的稳态模型评估后,脂肪肝疾病与CAC评分之间的关联仍然具有统计学意义。

结论
NAFLD和AFLD引起的早期肝病都与冠状动脉钙化的存在显着相关性。

原始出处:

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    2021-02-18 苏小雨

    学习了很多

    0

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  7. 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    2019-09-23 liujie6118

    通过超声将每日酒精摄入记录为克/天诊断肝脏脂肪

    0

  8. 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    2019-08-19 liujie6118

    受益匪浅

    0

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