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JGH:幽门螺杆菌感染与女性骨质疏松发生风险增高有关

2021-06-03 MedSci原创 MedSci原创

幽门螺杆菌是一种革兰氏阴性螺旋杆细菌,世界上有一半的人口有感染这种细菌,尤其是在发展中国家这样的现象更为普遍。幽门螺杆菌感染的临床表现。

      幽门螺杆菌是一种革兰氏阴性螺旋杆细菌,世界上有一半的人口有感染这种细菌,尤其是在发展中国家这样的现象更为普遍。幽门螺杆菌感染的临床表现包括胃肠道疾病,如胃炎、消化性溃疡病、胃黏膜相关淋巴组织和胃腺癌等。骨质疏松症是最常见的代谢性骨病之一,骨质疏松症随着世界老年人口的逐渐增加,已成为一个重要的全球健康问题。50 岁或以上成年人的骨质疏松症为 35.5%,中国老年人群髋部骨折1年死亡率为 16.6%,约为韩国的2.9 倍。骨质疏松症危险因素是年龄、性别、身材矮小,体重指数 (BMI)、吸烟、雌激素缺乏、长期使用糖皮质激素以及类风湿性关节炎等。幽门螺杆菌感染与骨质疏松症之间是否存在关联目前还不清楚。

 

      为此,研究人员对 10482 名基线时没有骨质疏松症的女性进行了一项前瞻性队列研究,这些女性参加了包括幽门螺杆菌特异性免疫球蛋白 G 抗体测试在内的筛查,以评估幽门螺杆菌与骨质疏松症发展之间的关联。骨质疏松症是使用双能 X 射线吸收测定法诊断的。

 

      在 77515.3 人年的随访中,幽门螺杆菌感染女性的骨质疏松症发生率高于未感染女性。在对年龄、体重指数 (BMI)、更年期状态、吸烟状态、规律运动、合并症(包括高血压、糖尿病、血脂异常、中风或缺血性心脏病)和伴随药物进行调整的多变量模型中,风险比(HR)为1.23(95% [CI],1.03–1.45)。在多变量分析中,更年期(HR,1.68;95% CI,1.31-2.16)和年龄增长(HR,1.07;95% CI,1.06-1.08)被确定为骨质疏松症的重要危险因素,而较高的 BMI(HR, 0.84;95% CI,0.81–0.87)是骨质疏松症风险的保护因素。

图:幽门螺杆菌感染女性的骨质疏松症发生率

       在这项队列研究中,研究人员证实幽门螺杆菌感染与骨质疏松症风险增加有关,而体重是骨质疏松的保护性因素。

 

 

原始出处:

Tae Jun Kim. Et al. Cohort study of Helicobacter pylori infection and the risk of incident osteoporosis in women.  Journal of Gastroenterology and Hepatology.2021.

 

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    2021-06-28 kcb069
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    2021-06-05 liuxiaona
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    2021-06-05 Eleven17

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