Baidu
map

Hypertension:可卡因通过miR-30c-5p -苹果酸酶1-活性氧通路升高血压、促进动脉僵硬

2018-03-03 MedSci MedSci原创

滥用可卡因会增加心血管疾病发病率和死亡率;但是,其潜在的分子机制仍未完全了解。现有研究人员利用滥用可卡因的小鼠模型,对其分子机制进行深入研究。研究人员发现,重复注射可卡因可导致与主动脉中活性氧(ROS)水平升高相关的小鼠血压升高和主动脉僵硬,该现象与人类高血压患者的相似。ROS高水平与Me1(苹果酸酶1:消除ROS产生的重要分子)下调相关;而miRNA-30c-5p表达上调,通过直接与Me1的3'

滥用可卡因会增加心血管疾病发病率和死亡率;但是,其潜在的分子机制仍未完全了解。现有研究人员利用滥用可卡因的小鼠模型,对其分子机制进行深入研究。

研究人员发现,重复注射可卡因可导致与主动脉中活性氧(ROS)水平升高相关的小鼠血压升高和主动脉僵硬,该现象与人类高血压患者的相似。ROS高水平与Me1(苹果酸酶1:消除ROS产生的重要分子)下调相关;而miRNA-30c-5p表达上调,通过直接与Me1的3'UTR区域结合调节Me1的表达。此外,用慢病毒介导在主动脉平滑肌细胞中过表达miR-30c-5p可再现可卡因对Me1表达的抑制作用,进而导致ROS升高。此外,沉默体内平滑肌细胞的miR-30c-5p可导致Me1表达上调、ROS减少,并显着抑制可卡因诱导的血压升高和动脉僵硬——与用抗氧化剂N-乙酰半胱氨酸治疗的效果相似。

综上所述,本研究发现了可卡因的作用通路,即可卡因-↑miR-30c-5p–↓Me1–↑ROS,为治疗可卡因滥用相关的心血管疾病提供新的潜在靶点。

原始出处:

Wei Zhu,et al.Cocaine Exposure Increases Blood Pressure and Aortic Stiffness via the miR-30c-5p–Malic Enzyme 1–Reactive Oxygen Species Pathway.Hypertension. February 26,2018.https://doi.org/10.1161/HYPERTENSIONAHA.117.10213

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (15)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1930588, encodeId=0091193058808, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Sun Mar 04 22:48:00 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038857, encodeId=24fa203885ed7, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Fri Sep 07 10:48:00 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727115, encodeId=8b361e27115ed, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu May 31 19:48:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1811222, encodeId=3efd181122286, content=<a href='/topic/show?id=71898e16717' target=_blank style='color:#2F92EE;'>#苹果酸酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87167, encryptionId=71898e16717, topicName=苹果酸酶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Wed Dec 12 08:48:00 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301375, encodeId=9e9913013e56c, content=<a href='/topic/show?id=b79c6521eb7' target=_blank style='color:#2F92EE;'>#活性氧#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65217, encryptionId=b79c6521eb7, topicName=活性氧)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2b4297, createdName=徐岩, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481693, encodeId=49f614816935b, content=<a href='/topic/show?id=7099384244c' target=_blank style='color:#2F92EE;'>#可卡因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38424, encryptionId=7099384244c, topicName=可卡因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbbf7815801, createdName=12498b3em10(暂无昵称), createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501269, encodeId=6dfd15012693d, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518700, encodeId=347d1518e00e5, content=<a href='/topic/show?id=79e18e15994' target=_blank style='color:#2F92EE;'>#苹果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87159, encryptionId=79e18e15994, topicName=苹果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f67111173924, createdName=okhuali, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546743, encodeId=dafd1546e43af, content=<a href='/topic/show?id=de1233215db' target=_blank style='color:#2F92EE;'>#动脉僵硬#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33215, encryptionId=de1233215db, topicName=动脉僵硬)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b48f13938152, createdName=dlwang_26703131, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292963, encodeId=166f292963ed, content=还好还好还好还好哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Sun Mar 04 18:46:37 CST 2018, time=2018-03-04, status=1, ipAttribution=)]
    2018-03-04 smallant2002
  2. [GetPortalCommentsPageByObjectIdResponse(id=1930588, encodeId=0091193058808, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Sun Mar 04 22:48:00 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038857, encodeId=24fa203885ed7, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Fri Sep 07 10:48:00 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727115, encodeId=8b361e27115ed, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu May 31 19:48:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1811222, encodeId=3efd181122286, content=<a href='/topic/show?id=71898e16717' target=_blank style='color:#2F92EE;'>#苹果酸酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87167, encryptionId=71898e16717, topicName=苹果酸酶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Wed Dec 12 08:48:00 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301375, encodeId=9e9913013e56c, content=<a href='/topic/show?id=b79c6521eb7' target=_blank style='color:#2F92EE;'>#活性氧#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65217, encryptionId=b79c6521eb7, topicName=活性氧)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2b4297, createdName=徐岩, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481693, encodeId=49f614816935b, content=<a href='/topic/show?id=7099384244c' target=_blank style='color:#2F92EE;'>#可卡因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38424, encryptionId=7099384244c, topicName=可卡因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbbf7815801, createdName=12498b3em10(暂无昵称), createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501269, encodeId=6dfd15012693d, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518700, encodeId=347d1518e00e5, content=<a href='/topic/show?id=79e18e15994' target=_blank style='color:#2F92EE;'>#苹果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87159, encryptionId=79e18e15994, topicName=苹果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f67111173924, createdName=okhuali, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546743, encodeId=dafd1546e43af, content=<a href='/topic/show?id=de1233215db' target=_blank style='color:#2F92EE;'>#动脉僵硬#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33215, encryptionId=de1233215db, topicName=动脉僵硬)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b48f13938152, createdName=dlwang_26703131, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292963, encodeId=166f292963ed, content=还好还好还好还好哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Sun Mar 04 18:46:37 CST 2018, time=2018-03-04, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1930588, encodeId=0091193058808, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Sun Mar 04 22:48:00 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038857, encodeId=24fa203885ed7, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Fri Sep 07 10:48:00 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727115, encodeId=8b361e27115ed, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu May 31 19:48:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1811222, encodeId=3efd181122286, content=<a href='/topic/show?id=71898e16717' target=_blank style='color:#2F92EE;'>#苹果酸酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87167, encryptionId=71898e16717, topicName=苹果酸酶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Wed Dec 12 08:48:00 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301375, encodeId=9e9913013e56c, content=<a href='/topic/show?id=b79c6521eb7' target=_blank style='color:#2F92EE;'>#活性氧#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65217, encryptionId=b79c6521eb7, topicName=活性氧)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2b4297, createdName=徐岩, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481693, encodeId=49f614816935b, content=<a href='/topic/show?id=7099384244c' target=_blank style='color:#2F92EE;'>#可卡因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38424, encryptionId=7099384244c, topicName=可卡因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbbf7815801, createdName=12498b3em10(暂无昵称), createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501269, encodeId=6dfd15012693d, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518700, encodeId=347d1518e00e5, content=<a href='/topic/show?id=79e18e15994' target=_blank style='color:#2F92EE;'>#苹果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87159, encryptionId=79e18e15994, topicName=苹果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f67111173924, createdName=okhuali, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546743, encodeId=dafd1546e43af, content=<a href='/topic/show?id=de1233215db' target=_blank style='color:#2F92EE;'>#动脉僵硬#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33215, encryptionId=de1233215db, topicName=动脉僵硬)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b48f13938152, createdName=dlwang_26703131, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292963, encodeId=166f292963ed, content=还好还好还好还好哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Sun Mar 04 18:46:37 CST 2018, time=2018-03-04, status=1, ipAttribution=)]
    2018-05-31 feather89
  4. [GetPortalCommentsPageByObjectIdResponse(id=1930588, encodeId=0091193058808, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Sun Mar 04 22:48:00 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038857, encodeId=24fa203885ed7, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Fri Sep 07 10:48:00 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727115, encodeId=8b361e27115ed, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu May 31 19:48:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1811222, encodeId=3efd181122286, content=<a href='/topic/show?id=71898e16717' target=_blank style='color:#2F92EE;'>#苹果酸酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87167, encryptionId=71898e16717, topicName=苹果酸酶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Wed Dec 12 08:48:00 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301375, encodeId=9e9913013e56c, content=<a href='/topic/show?id=b79c6521eb7' target=_blank style='color:#2F92EE;'>#活性氧#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65217, encryptionId=b79c6521eb7, topicName=活性氧)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2b4297, createdName=徐岩, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481693, encodeId=49f614816935b, content=<a href='/topic/show?id=7099384244c' target=_blank style='color:#2F92EE;'>#可卡因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38424, encryptionId=7099384244c, topicName=可卡因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbbf7815801, createdName=12498b3em10(暂无昵称), createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501269, encodeId=6dfd15012693d, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518700, encodeId=347d1518e00e5, content=<a href='/topic/show?id=79e18e15994' target=_blank style='color:#2F92EE;'>#苹果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87159, encryptionId=79e18e15994, topicName=苹果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f67111173924, createdName=okhuali, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546743, encodeId=dafd1546e43af, content=<a href='/topic/show?id=de1233215db' target=_blank style='color:#2F92EE;'>#动脉僵硬#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33215, encryptionId=de1233215db, topicName=动脉僵硬)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b48f13938152, createdName=dlwang_26703131, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292963, encodeId=166f292963ed, content=还好还好还好还好哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Sun Mar 04 18:46:37 CST 2018, time=2018-03-04, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1930588, encodeId=0091193058808, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Sun Mar 04 22:48:00 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038857, encodeId=24fa203885ed7, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Fri Sep 07 10:48:00 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727115, encodeId=8b361e27115ed, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu May 31 19:48:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1811222, encodeId=3efd181122286, content=<a href='/topic/show?id=71898e16717' target=_blank style='color:#2F92EE;'>#苹果酸酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87167, encryptionId=71898e16717, topicName=苹果酸酶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Wed Dec 12 08:48:00 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301375, encodeId=9e9913013e56c, content=<a href='/topic/show?id=b79c6521eb7' target=_blank style='color:#2F92EE;'>#活性氧#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65217, encryptionId=b79c6521eb7, topicName=活性氧)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2b4297, createdName=徐岩, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481693, encodeId=49f614816935b, content=<a href='/topic/show?id=7099384244c' target=_blank style='color:#2F92EE;'>#可卡因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38424, encryptionId=7099384244c, topicName=可卡因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbbf7815801, createdName=12498b3em10(暂无昵称), createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501269, encodeId=6dfd15012693d, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518700, encodeId=347d1518e00e5, content=<a href='/topic/show?id=79e18e15994' target=_blank style='color:#2F92EE;'>#苹果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87159, encryptionId=79e18e15994, topicName=苹果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f67111173924, createdName=okhuali, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546743, encodeId=dafd1546e43af, content=<a href='/topic/show?id=de1233215db' target=_blank style='color:#2F92EE;'>#动脉僵硬#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33215, encryptionId=de1233215db, topicName=动脉僵硬)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b48f13938152, createdName=dlwang_26703131, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292963, encodeId=166f292963ed, content=还好还好还好还好哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Sun Mar 04 18:46:37 CST 2018, time=2018-03-04, status=1, ipAttribution=)]
    2018-03-05 徐岩
  6. [GetPortalCommentsPageByObjectIdResponse(id=1930588, encodeId=0091193058808, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Sun Mar 04 22:48:00 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038857, encodeId=24fa203885ed7, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Fri Sep 07 10:48:00 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727115, encodeId=8b361e27115ed, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu May 31 19:48:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1811222, encodeId=3efd181122286, content=<a href='/topic/show?id=71898e16717' target=_blank style='color:#2F92EE;'>#苹果酸酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87167, encryptionId=71898e16717, topicName=苹果酸酶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Wed Dec 12 08:48:00 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301375, encodeId=9e9913013e56c, content=<a href='/topic/show?id=b79c6521eb7' target=_blank style='color:#2F92EE;'>#活性氧#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65217, encryptionId=b79c6521eb7, topicName=活性氧)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2b4297, createdName=徐岩, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481693, encodeId=49f614816935b, content=<a href='/topic/show?id=7099384244c' target=_blank style='color:#2F92EE;'>#可卡因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38424, encryptionId=7099384244c, topicName=可卡因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbbf7815801, createdName=12498b3em10(暂无昵称), createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501269, encodeId=6dfd15012693d, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518700, encodeId=347d1518e00e5, content=<a href='/topic/show?id=79e18e15994' target=_blank style='color:#2F92EE;'>#苹果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87159, encryptionId=79e18e15994, topicName=苹果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f67111173924, createdName=okhuali, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546743, encodeId=dafd1546e43af, content=<a href='/topic/show?id=de1233215db' target=_blank style='color:#2F92EE;'>#动脉僵硬#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33215, encryptionId=de1233215db, topicName=动脉僵硬)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b48f13938152, createdName=dlwang_26703131, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292963, encodeId=166f292963ed, content=还好还好还好还好哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Sun Mar 04 18:46:37 CST 2018, time=2018-03-04, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1930588, encodeId=0091193058808, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Sun Mar 04 22:48:00 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038857, encodeId=24fa203885ed7, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Fri Sep 07 10:48:00 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727115, encodeId=8b361e27115ed, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu May 31 19:48:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1811222, encodeId=3efd181122286, content=<a href='/topic/show?id=71898e16717' target=_blank style='color:#2F92EE;'>#苹果酸酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87167, encryptionId=71898e16717, topicName=苹果酸酶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Wed Dec 12 08:48:00 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301375, encodeId=9e9913013e56c, content=<a href='/topic/show?id=b79c6521eb7' target=_blank style='color:#2F92EE;'>#活性氧#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65217, encryptionId=b79c6521eb7, topicName=活性氧)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2b4297, createdName=徐岩, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481693, encodeId=49f614816935b, content=<a href='/topic/show?id=7099384244c' target=_blank style='color:#2F92EE;'>#可卡因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38424, encryptionId=7099384244c, topicName=可卡因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbbf7815801, createdName=12498b3em10(暂无昵称), createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501269, encodeId=6dfd15012693d, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518700, encodeId=347d1518e00e5, content=<a href='/topic/show?id=79e18e15994' target=_blank style='color:#2F92EE;'>#苹果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87159, encryptionId=79e18e15994, topicName=苹果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f67111173924, createdName=okhuali, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546743, encodeId=dafd1546e43af, content=<a href='/topic/show?id=de1233215db' target=_blank style='color:#2F92EE;'>#动脉僵硬#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33215, encryptionId=de1233215db, topicName=动脉僵硬)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b48f13938152, createdName=dlwang_26703131, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292963, encodeId=166f292963ed, content=还好还好还好还好哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Sun Mar 04 18:46:37 CST 2018, time=2018-03-04, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1930588, encodeId=0091193058808, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Sun Mar 04 22:48:00 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038857, encodeId=24fa203885ed7, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Fri Sep 07 10:48:00 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727115, encodeId=8b361e27115ed, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu May 31 19:48:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1811222, encodeId=3efd181122286, content=<a href='/topic/show?id=71898e16717' target=_blank style='color:#2F92EE;'>#苹果酸酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87167, encryptionId=71898e16717, topicName=苹果酸酶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Wed Dec 12 08:48:00 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301375, encodeId=9e9913013e56c, content=<a href='/topic/show?id=b79c6521eb7' target=_blank style='color:#2F92EE;'>#活性氧#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65217, encryptionId=b79c6521eb7, topicName=活性氧)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2b4297, createdName=徐岩, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481693, encodeId=49f614816935b, content=<a href='/topic/show?id=7099384244c' target=_blank style='color:#2F92EE;'>#可卡因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38424, encryptionId=7099384244c, topicName=可卡因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbbf7815801, createdName=12498b3em10(暂无昵称), createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501269, encodeId=6dfd15012693d, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518700, encodeId=347d1518e00e5, content=<a href='/topic/show?id=79e18e15994' target=_blank style='color:#2F92EE;'>#苹果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87159, encryptionId=79e18e15994, topicName=苹果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f67111173924, createdName=okhuali, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546743, encodeId=dafd1546e43af, content=<a href='/topic/show?id=de1233215db' target=_blank style='color:#2F92EE;'>#动脉僵硬#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33215, encryptionId=de1233215db, topicName=动脉僵硬)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b48f13938152, createdName=dlwang_26703131, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292963, encodeId=166f292963ed, content=还好还好还好还好哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Sun Mar 04 18:46:37 CST 2018, time=2018-03-04, status=1, ipAttribution=)]
    2018-03-05 okhuali
  9. [GetPortalCommentsPageByObjectIdResponse(id=1930588, encodeId=0091193058808, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Sun Mar 04 22:48:00 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038857, encodeId=24fa203885ed7, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Fri Sep 07 10:48:00 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727115, encodeId=8b361e27115ed, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu May 31 19:48:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1811222, encodeId=3efd181122286, content=<a href='/topic/show?id=71898e16717' target=_blank style='color:#2F92EE;'>#苹果酸酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87167, encryptionId=71898e16717, topicName=苹果酸酶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Wed Dec 12 08:48:00 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301375, encodeId=9e9913013e56c, content=<a href='/topic/show?id=b79c6521eb7' target=_blank style='color:#2F92EE;'>#活性氧#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65217, encryptionId=b79c6521eb7, topicName=活性氧)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2b4297, createdName=徐岩, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481693, encodeId=49f614816935b, content=<a href='/topic/show?id=7099384244c' target=_blank style='color:#2F92EE;'>#可卡因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38424, encryptionId=7099384244c, topicName=可卡因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbbf7815801, createdName=12498b3em10(暂无昵称), createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501269, encodeId=6dfd15012693d, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518700, encodeId=347d1518e00e5, content=<a href='/topic/show?id=79e18e15994' target=_blank style='color:#2F92EE;'>#苹果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87159, encryptionId=79e18e15994, topicName=苹果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f67111173924, createdName=okhuali, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546743, encodeId=dafd1546e43af, content=<a href='/topic/show?id=de1233215db' target=_blank style='color:#2F92EE;'>#动脉僵硬#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33215, encryptionId=de1233215db, topicName=动脉僵硬)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b48f13938152, createdName=dlwang_26703131, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292963, encodeId=166f292963ed, content=还好还好还好还好哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Sun Mar 04 18:46:37 CST 2018, time=2018-03-04, status=1, ipAttribution=)]
  10. [GetPortalCommentsPageByObjectIdResponse(id=1930588, encodeId=0091193058808, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Sun Mar 04 22:48:00 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038857, encodeId=24fa203885ed7, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Fri Sep 07 10:48:00 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727115, encodeId=8b361e27115ed, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu May 31 19:48:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1811222, encodeId=3efd181122286, content=<a href='/topic/show?id=71898e16717' target=_blank style='color:#2F92EE;'>#苹果酸酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87167, encryptionId=71898e16717, topicName=苹果酸酶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Wed Dec 12 08:48:00 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301375, encodeId=9e9913013e56c, content=<a href='/topic/show?id=b79c6521eb7' target=_blank style='color:#2F92EE;'>#活性氧#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65217, encryptionId=b79c6521eb7, topicName=活性氧)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2b4297, createdName=徐岩, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481693, encodeId=49f614816935b, content=<a href='/topic/show?id=7099384244c' target=_blank style='color:#2F92EE;'>#可卡因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38424, encryptionId=7099384244c, topicName=可卡因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbbf7815801, createdName=12498b3em10(暂无昵称), createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501269, encodeId=6dfd15012693d, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518700, encodeId=347d1518e00e5, content=<a href='/topic/show?id=79e18e15994' target=_blank style='color:#2F92EE;'>#苹果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87159, encryptionId=79e18e15994, topicName=苹果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f67111173924, createdName=okhuali, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546743, encodeId=dafd1546e43af, content=<a href='/topic/show?id=de1233215db' target=_blank style='color:#2F92EE;'>#动脉僵硬#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33215, encryptionId=de1233215db, topicName=动脉僵硬)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b48f13938152, createdName=dlwang_26703131, createdTime=Mon Mar 05 07:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292963, encodeId=166f292963ed, content=还好还好还好还好哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Sun Mar 04 18:46:37 CST 2018, time=2018-03-04, status=1, ipAttribution=)]
    2018-03-04 为你把脉

    还好还好还好还好哈

    0

相关资讯

AIDS 2016:使用可卡因会增加HIV患者肝脏疾病风险

AIDS 2016上公布的数据显示,对使用可卡因的HIV患者随访1年后发现,可卡因的使用与更高水平的肝细胞凋亡和肝纤维化进展有关。此外,可卡因的使用还与HIV病毒载量的增加和BMI的下降有关。罗伯特大学公共卫生和社会工作的Marianna K. Baum博士和同事对259名(平均年龄为47.2岁)感染HIV,但没有感染HBV或HCV的患者进行了1年随访研究。研究人员检查了肝脏疾病的生物标志物,包括

指阿片样药物危机!澳大利亚禁止以非处方形式使用可卡因药物

澳大利亚成为了最新一个禁止以非处方形式使用包含阿片样止痛药的国家,这项新规定将在2018年2月1日生效,旨在降低可卡因导致的死亡人数。据统计2000年至今,澳大利亚由于可卡因致死的人数已经翻了两番。 可卡因可用于止痛、止咳,据研究报道,一些止痛药、止咳糖浆及感冒、流感药片中均含有低剂量可卡因,而在澳大利亚及英国不需要开处方就可以购买这些药物。 但是即使是低剂量的可卡因也有让人上瘾的风险,因为它

可卡因,上瘾背后的机制

你们知道世界上最易上瘾的物质有哪些吗?海洛因、可卡因、尼古丁、巴比妥酸盐、酒精是上瘾性最高的几类药物。一旦进入大脑,它们都会刺激多巴胺,通过奖赏回路促使大脑兴奋和愉快,从而使人沉迷而欲罢不能。

Alcohol:青春期饮用混合酒精和咖啡因的功能饮料可与可卡因一样影响大脑

近日,来自普渡大学的一项研究表明,饮用咖啡因含量很高的酒精饮料可引起与青少年使用可卡因相似的的大脑变化,且其后果持续到成年期,该研究结果已发表于Alcohol。 研究人员对青少年喂以咖啡因含量很高的能量饮料,以观察对小鼠大脑的影响。结果发现,与对照组小鼠相比,高咖啡因能量饮料组小鼠成年期并不会饮用更多地酒精。 但是当将高水平的咖啡因与酒精混合后喂以青少年小鼠后发现小鼠大脑的物理和神经化

BMJ:病例挑战——胸痛和T波倒置一定是心肌缺血吗?

BMJ:病例挑战——胸痛和T波倒置一定是心肌缺血吗?男性患者,55岁,长途飞行后感到胸部和腹部不适。患者胸部不适的症状与其稳定型心绞痛的表现相似。入院时患者的心率为90次/分,血压为95/52 mm Hg。心电图显示,下侧壁导联T波倒置,提示心肌缺血,尽管患者血清肌钙蛋白和D-二聚体检测结果均为阴性。动脉血气、PH和乳酸的水平正常。患者仰卧位腹部平片显示了什么?哪些迹象可以做出此诊断?答案:X线片

Neuron:线粒体分裂和可卡因成瘾关系

已有的研究表明,在可卡因成瘾过程中,脑内能量平衡的改变是大脑中发生的一个关键适应过程。但是至今为止,可卡因对线粒体,能量的根本来源,的影响还是未知的。

Baidu
map
Baidu
map
Baidu
map