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Nano Lett:新型水凝胶让癌细胞“共享实时位置”

2020-01-20 张建新 焦德芳 新华网

天津大学仰大勇教授团队近日成功研发新型长余辉水凝胶。这种新型水凝胶进入活体后能够长时间标记在肿瘤细胞上发出近红外光,让癌细胞“共享实时位置”,追踪癌细胞的转移途径,有望成为癌症治疗的利器。

天津大学仰大勇教授团队近日成功研发新型长余辉水凝胶。这种新型水凝胶进入活体后能够长时间标记在肿瘤细胞上发出近红外光,让癌细胞“共享实时位置”,追踪癌细胞的转移途径,有望成为癌症治疗的利器。

相关成果现已发表于纳米科技领域权威期刊《纳米快报》。

恶性肿瘤的转移是癌症治疗失败的主要原因。肿瘤转移是指肿瘤细胞从原发部位经淋巴道和血管等途径到达其他部位继续生长形成转移瘤的过程。转移瘤一般尺寸微小、形态多样,随机分布在不同器官,导致癌症难以治愈。因此,发展监测肿瘤转移过程的新方法新技术研究肿瘤细胞的转移行为,对于肿瘤治疗具有重要意义。

天津大学化工学院仰大勇教授课题组成功研发“长余辉水凝胶”。“长余辉水凝胶”进入人体后,能够在无外界光激发时,长时间自主持续发出近红外光,实现无背景干扰的深组织成像,用于肿瘤转移的可视化成像研究。这种新型水凝胶由肿瘤特异靶向性的“长余辉纳米探针”和“海藻酸钠水凝胶”构成,通过表面修饰肿瘤特异性配体,能够靶向识别、持续标记不同肿瘤细胞,并让肿瘤细胞的转移活动形成一幅发光的“实时位置轨迹图”。

乳腺癌小鼠模型实验结果显示,这种新型水凝胶生物相容性好,无毒无副作用,对肿瘤没有影响,并具有很高的灵敏度,能够克服干扰在小鼠的肿瘤部位持续释放发光标记探针,标记肿瘤细胞,实现肿瘤转移的无创、高选择性、无背景干扰成像示踪。

据仰大勇教授介绍,这种新型“长余辉水凝胶”可以针对各种类型的癌细胞进行定制化设计,从而为各种肿瘤转移研究提供通用性检测平台,在癌症治疗等领域具有广阔前景。

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    2020-01-22 yxch36
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    2020-01-22 tastas
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    2020-01-22 lishizhe
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    2020-01-22 zhaojie88

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