Baidu
map

Science:神奇!与过敏症相关联的T细胞也能促进组织再生!

2016-04-18 佚名 生物谷

2016年4月17日/生物谷BIOON/--在一项新的研究中,来自美国约翰霍普金斯大学和肯尼迪-克里格研究所(Kennedy Krieger Institute)的研究人员报道,与过敏症相关联的免疫细胞当与生物材料支架(biomaterial scaffold)配合使用时会直接让小鼠肌肉损伤愈合。这一发现进一步证明免疫系统不仅在抵抗传染性疾病和其他疾病中发挥着关键作用,而且也在损伤后启动愈合过程中发挥着关键作用。研究人员也指出这些设计出的生物材料支架与免疫细胞“形成搭档”时能够更加有效地促进愈合。相关研究结果发表在2016年4月15日那期Science期刊上,论文标题为“Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells”。
 
论文通信作者、约翰霍普金斯大学医学院眼科学与生物医学工程教授Jennifer Elisseeff博士说,“在之前的研究中,我们已观察到对植入到不同的组织或环境中的相同生物材料做出的不同免疫反应,这让我们有兴趣研究生物材料会如何刺激免疫系统,促进再生。我们仍然有很多地方需要学习,但是这项研究在设计生物材料引发有益的免疫反应方面迈进了一步。”
 
Elisseeff的研究团队设计可生物降解的由诸如胶原蛋白之类的生物材料制作而成的支架,已证实这种支架有望促进受损组织再生,这种促进部分上是支架给身体自己的干细胞提供附着的地方然后开始它们的再生过程。她说,但是在过去的几年,其他的研究团队已发现证据表明这类支架也会促进免疫细胞的愈合活性。
 
为了更多地了解所涉及的免疫细胞及其它们的免疫反应,当时还是研究生的Kaitlyn Sadtler与Elisseeff实验室的其他研究人员和癌症免疫学专家一起合作开展研究。他们通过外科手术切除小鼠大腿肌肉中的一部分,然后植入已知促进动物伤口愈合的支架。一个星期后,含有支架的伤口位点要比没有支架的伤口位点拥有更多的白细胞,而且许多白细胞大量产生一种化学信号分子:白细胞介素-4(IL-4),这种信号分子通常是由所谓的2型辅助性T细胞(type 2 helper T cell, Th2细胞)所产生的。
 
为了观察这些细胞可能发挥什么作用,研究人员利用经过基因改造缺乏T细胞的小鼠开展同样的实验,结果发现它们的伤口不能产生白细胞介素,也不能像正常小鼠那样愈合。进一步的研究揭示出在伤口位点,Th2细胞激活和教导另一种类型的被称作巨噬细胞的免疫细胞。Sadtler说,“这些T细胞告诉巨噬细胞如何行动,让它们变成促进再生的巨噬细胞。”
 
之前的研究提示着巨噬细胞的几种关键的愈合作用:清除死亡或受损的细胞和其他碎片,招募和支持成体干细胞再生组织,以及促进新的血管形成以便促进新组织再生。但是,Elisseeff说,在支架中的Th2细胞所起到的关键作用令人吃惊:这些T细胞有助抵御肠道蠕虫,但在发达国家,肠道蠕虫经常与触发“不好”免疫反应(如过敏症)相关联。
 
Elisseeff指出仍然需要更多了解免疫细胞如何对可能用作支架的各种生物材料作出反应---一个她的研究团队仍在继续研究的领域。
 
论文共同作者、约翰霍普金斯大学基梅尔癌症中心(Kimmel Cancer Center)肿瘤学教授Drew Pardoll博士说,“这项研究首次证实T细胞在调控组织再生过程中的核心作用,确实是突破性的。我预测这将会被视作为一个转折点:再生免疫学将从一种想法变成一个值得认真研究的领域。而且它为开发显著增强组织再生的全新策略打开大门。”(生物谷 Bioon.com)

本文系生物谷原创编译整理,欢迎转载!点击 获取授权 。更多资讯请下载生物谷APP

Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells

doi:10.1126/science.aad9272

Immune-mediated tissue regeneration driven by a biomaterial scaffold is emerging as an innovative regenerative strategy to repair damaged tissues. We investigated how biomaterial scaffolds shape the immune microenvironment in traumatic muscle wounds to improve tissue regeneration. The scaffolds induced a pro-regenerative response, characterized by an mTOR/Rictor-dependent T helper 2 pathway that guides interleukin-4–dependent macrophage polarization, which is critical for functional muscle recovery. Manipulating the adaptive immune system using biomaterials engineering may support the development of therapies that promote both systemic and local pro-regenerative immune responses, ultimately stimulating tissue repair.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=81239, encodeId=f8508123938, content=淋巴细胞与免疫损伤有关……该文指出存在搭挡时能促进愈合坛加了新认识, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e8231711773, createdName=1dea6088m20(暂无匿称), createdTime=Fri Apr 22 22:53:00 CST 2016, time=2016-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375216, encodeId=05a313e52163b, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Wed Apr 20 00:28:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516438, encodeId=df4315164381f, content=<a href='/topic/show?id=0c06940668a' target=_blank style='color:#2F92EE;'>#过敏症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94066, encryptionId=0c06940668a, topicName=过敏症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=def310968681, createdName=ms1948154235210413, createdTime=Wed Apr 20 00:28:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591975, encodeId=52d815919e53e, content=<a href='/topic/show?id=595ce765983' target=_blank style='color:#2F92EE;'>#组织再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77659, encryptionId=595ce765983, topicName=组织再生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11e818060478, createdName=sunyl13, createdTime=Wed Apr 20 00:28:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79455, encodeId=6bf6e945513, content=高大上的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Tue Apr 19 01:02:00 CST 2016, time=2016-04-19, status=1, ipAttribution=)]
    2016-04-22 1dea6088m20(暂无匿称)

    淋巴细胞与免疫损伤有关……该文指出存在搭挡时能促进愈合坛加了新认识

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=81239, encodeId=f8508123938, content=淋巴细胞与免疫损伤有关……该文指出存在搭挡时能促进愈合坛加了新认识, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e8231711773, createdName=1dea6088m20(暂无匿称), createdTime=Fri Apr 22 22:53:00 CST 2016, time=2016-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375216, encodeId=05a313e52163b, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Wed Apr 20 00:28:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516438, encodeId=df4315164381f, content=<a href='/topic/show?id=0c06940668a' target=_blank style='color:#2F92EE;'>#过敏症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94066, encryptionId=0c06940668a, topicName=过敏症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=def310968681, createdName=ms1948154235210413, createdTime=Wed Apr 20 00:28:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591975, encodeId=52d815919e53e, content=<a href='/topic/show?id=595ce765983' target=_blank style='color:#2F92EE;'>#组织再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77659, encryptionId=595ce765983, topicName=组织再生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11e818060478, createdName=sunyl13, createdTime=Wed Apr 20 00:28:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79455, encodeId=6bf6e945513, content=高大上的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Tue Apr 19 01:02:00 CST 2016, time=2016-04-19, status=1, ipAttribution=)]
    2016-04-20 jichang
  3. [GetPortalCommentsPageByObjectIdResponse(id=81239, encodeId=f8508123938, content=淋巴细胞与免疫损伤有关……该文指出存在搭挡时能促进愈合坛加了新认识, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e8231711773, createdName=1dea6088m20(暂无匿称), createdTime=Fri Apr 22 22:53:00 CST 2016, time=2016-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375216, encodeId=05a313e52163b, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Wed Apr 20 00:28:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516438, encodeId=df4315164381f, content=<a href='/topic/show?id=0c06940668a' target=_blank style='color:#2F92EE;'>#过敏症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94066, encryptionId=0c06940668a, topicName=过敏症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=def310968681, createdName=ms1948154235210413, createdTime=Wed Apr 20 00:28:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591975, encodeId=52d815919e53e, content=<a href='/topic/show?id=595ce765983' target=_blank style='color:#2F92EE;'>#组织再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77659, encryptionId=595ce765983, topicName=组织再生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11e818060478, createdName=sunyl13, createdTime=Wed Apr 20 00:28:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79455, encodeId=6bf6e945513, content=高大上的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Tue Apr 19 01:02:00 CST 2016, time=2016-04-19, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=81239, encodeId=f8508123938, content=淋巴细胞与免疫损伤有关……该文指出存在搭挡时能促进愈合坛加了新认识, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e8231711773, createdName=1dea6088m20(暂无匿称), createdTime=Fri Apr 22 22:53:00 CST 2016, time=2016-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375216, encodeId=05a313e52163b, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Wed Apr 20 00:28:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516438, encodeId=df4315164381f, content=<a href='/topic/show?id=0c06940668a' target=_blank style='color:#2F92EE;'>#过敏症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94066, encryptionId=0c06940668a, topicName=过敏症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=def310968681, createdName=ms1948154235210413, createdTime=Wed Apr 20 00:28:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591975, encodeId=52d815919e53e, content=<a href='/topic/show?id=595ce765983' target=_blank style='color:#2F92EE;'>#组织再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77659, encryptionId=595ce765983, topicName=组织再生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11e818060478, createdName=sunyl13, createdTime=Wed Apr 20 00:28:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79455, encodeId=6bf6e945513, content=高大上的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Tue Apr 19 01:02:00 CST 2016, time=2016-04-19, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=81239, encodeId=f8508123938, content=淋巴细胞与免疫损伤有关……该文指出存在搭挡时能促进愈合坛加了新认识, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e8231711773, createdName=1dea6088m20(暂无匿称), createdTime=Fri Apr 22 22:53:00 CST 2016, time=2016-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375216, encodeId=05a313e52163b, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Wed Apr 20 00:28:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516438, encodeId=df4315164381f, content=<a href='/topic/show?id=0c06940668a' target=_blank style='color:#2F92EE;'>#过敏症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94066, encryptionId=0c06940668a, topicName=过敏症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=def310968681, createdName=ms1948154235210413, createdTime=Wed Apr 20 00:28:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591975, encodeId=52d815919e53e, content=<a href='/topic/show?id=595ce765983' target=_blank style='color:#2F92EE;'>#组织再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77659, encryptionId=595ce765983, topicName=组织再生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11e818060478, createdName=sunyl13, createdTime=Wed Apr 20 00:28:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79455, encodeId=6bf6e945513, content=高大上的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Tue Apr 19 01:02:00 CST 2016, time=2016-04-19, status=1, ipAttribution=)]
    2016-04-19 李继凯

    高大上的文章

    0

相关资讯

Science:免疫细胞杀敌新策略

近日,刊登在国际杂志Science上的一项研究论文中,来自美国罗切斯特大学的研究人员通过研究表示,就好象成群飞翔的鸟儿能够学会如何节约能量,蚂蚁能够开创殖民地来保护蚁王,免疫细胞也会参与协调行为来清除消灭机体中的病毒,比如流感病毒等。文章中,研究者首次揭示了免疫细胞如何发挥作用来达到其目的地—感染或损伤位点,当机体处于开放状态时,病毒或细菌就会占据多个机体位点:肺部、咽喉、皮肤、胃部或者耳朵,而

Science:研究发现免疫细胞在ALS中发挥意想不到的作用

在最新发表于《Science》期刊的研究中,Cedars-Sinai医学中心研究科学家们发现,大脑中的免疫细胞在肌萎缩侧索硬化(amyotrophic lateral sclerosis,ALS)的发展中发挥直接作用,为针对这种神经退行性疾病的新疗法提供了希望。 研究人员专注于被称为C9orf72的基因,该基因中的突变会导致ALS和额颞叶痴呆(FTD)。FTD是另一种神经系统疾病,通常会造成患者

Nat Commun:磁场驱动免疫细胞成为肿瘤“专职杀手”

 最新发表在Nature Communications上的一项研究认为,临床磁共振成像(MRI)系统在小鼠中可被用来引导特殊的细胞,可以将这些特殊的细胞引导到肿瘤部位,利用这些特殊细胞携带的溶瘤病毒可以杀死癌细胞,从而抑制肿瘤的生长。这些发现表明,在小鼠模型中,由MRI系统产生的磁场能够像GPS一样,为“杀手”提供肿瘤的定向位置信息,并为消灭癌细胞提供重要的先决条件,更深入的研究可能可以

Immunity:免疫细胞如何帮助抵御肥胖

9月15日发表在Immunity杂志上的一项新的研究表明,众所周知,健康的生活方式和“好”的基因有助于阻止肥胖发生,免疫系统的某些方面对此也发挥着重要的作用。在新的研究中,科学家们发现老鼠缺乏一种获得多余重量的特殊的免疫细胞,并且即使它们饮食非常标准然而它们的代谢是异常的。在过去的几年里,代谢和免疫系统之间的关系受到越来越多的关注。先前的研究发现,某些免疫细胞有助于控制脂肪组织释放或储存能量。此

上海“下一代CAR与免疫细胞治疗研讨会”后记一 “杀死最后一个癌细胞”

一整天的上海“下一代CAR与免疫细胞治疗研讨会”圆满结束,聆听了很多CAR大伽们精彩报告,有新的CAR治疗靶点、有新的CART临床研究进展、有新的CART产业化技术、还有新的疟原虫与肿瘤的关系的研究等等,受益良多。其中,宾大陈有海教授的“癌症治疗的难点是杀死最后一个癌细胞”印象很深刻。这句话立即让我想起协和(印象是协和的)的一个外科专家的一句很经典的评述“再好的外科大夫也切不掉最后一个癌细胞"

Nature:癌细胞通过自身死亡欺骗免疫细胞,实现转移

加州大学旧金山分校的科学家们第一次在一个小鼠转移癌模型中,直接观察到了当侵袭性癌细胞迁移到肺脏时它们是如何建立滩头阵地的。他们看到的非常令人惊讶:定位在肺脏的早期“先头”癌细胞通常死亡,但它们首先放出了一些僵尸样的颗粒,这些颗粒可以自身四处移动,被一波波免疫细胞所吞噬。就好像被这些癌症颗粒感染了一样,其中许多的免疫细胞随后会钻入到肺组织中,为未来通过血液漂浮安全定居并形成新转移灶的癌细胞开辟空间。

Baidu
map
Baidu
map
Baidu
map