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J Endod:体内评估术前布洛芬对不可逆牙髓炎促炎症因子的影响

2020-07-19 lishiting MedSci原创

这篇研究的目的是为了比较罹患不可逆牙髓炎患者术前给予布洛芬后牙髓中促炎症因子的水平与未给予药物患者之间的差异。

研究建议,术前NSAIDs管理可作为增加有症状不可逆牙髓炎局部麻醉的效果和减轻术后疼痛的一种方法。然而,布洛芬在分子水平上的作用还未可知。因此,这篇研究的目的是为了比较罹患不可逆牙髓炎患者术前给予布洛芬后牙髓中促炎症因子的水平与未给予药物患者之间的差异。

研究选取了34颗经历常规牙髓治疗的罹患不可逆牙髓炎患牙并随机非为布洛芬或非布洛芬组。4名由于修复原因实施牙髓治疗的患者作为对照。布洛芬组的患者在术前1小时给予口服600mg的布洛芬,而非布洛芬组和对照组的患者被建议术前不服用任何镇痛药物。通过高敏感ELISAs检测开髓后髓腔内获取的血液中的PGE2, TNF-α, IL-6, IL-1β和IFN-γ水平。记录各组术后疼痛的水平。对细胞因子水平和术后疼痛数据进行统计学分析。

结果显示,与非布洛芬组相比,布洛芬组中PGE2, TNF-α, IL-6和IFN-γ的水平显著降低。各组之间术后疼痛水平未见显著性差异。

结论:数据表明,术前布洛芬能够显著减弱牙髓中大多数促炎症因子的水平,这可能有助于不可逆牙髓炎病例中的麻醉效果。

原始出处

Vicky Nguyen, Yen-Wei Chen, et al. In vivo evaluation of effect of pre-operative ibuprofen on pro-inflammatory mediators in irreversible pulpitis cases. J Endod., 2020 Jun 18;S0099-2399(20)30399-X. doi: 10.1016/j.joen.2020.06.009.

 

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    2021-01-23 jxrzshh
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    2020-07-25 悠然见浮山

    学习了

    0

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