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Diabetes Care:体重减轻对2型糖尿病患者脆性骨折的影响

2018-03-15 xing.T MedSci原创

由此可见,目前的研究表明,最大体重减轻≥20%是2型糖尿病患者发生骨折的一个重要危险因素,尤其是男性。

越来越多的证据表明,在一般人群中,体重减轻与骨折风险增加有关。由于糖尿病患者经常有意或无意地减肥,近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,
研究人员的目的是前瞻性地评估体重从最大值减轻与骨折风险之间的关系。

该研究共纳入了4706名日本2型糖尿病参与者(平均年龄为66岁),包括2755名男性和1951名绝经后妇女,随访中位数为5.3年,根据从最大体重减轻程度分为:<10%、10%-20%、20%-30%和≥30%。该研究的主要结局为脆性骨折,定义为髋部和脊柱骨折。

在随访期间,198名参与者发生了脆性骨折。经年龄和性别调整后的发病率为每1000人每年为6.4人(最大体重减轻程度<10%)、7.8人(10%-20%)、11.7人(20%-30%)和19.2人(≥30%)(趋势P<0.001)。以最大体重减轻程度<10%的组为对照组,最大体重减轻10-20%、20%-30%和≥30%的男性患者发生脆性骨折多变量调整后的风险比分别为1.48(95%CI为0.79–2.77)、2.23(1.08–4.64)和5.20(2.15–12.57),而在绝经后女性中分别为1.19(0.78–1.82)、1.62(0.96–2.73)和1.97(0.84–4.62)。

由此可见,目前的研究表明,最大体重减轻≥20%是2型糖尿病患者发生骨折的一个重要危险因素,尤其是男性。

原始出处:

Yuji Komorita,et al.Impact of Body Weight Loss From Maximum Weight on Fragility Bone Fractures in Japanese Patients With type 2 Diabetes: the Fukuoka Diabetes Registry.Diabetes Care.2018. https://doi.org/10.2337/dc17-2004

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  8. [GetPortalCommentsPageByObjectIdResponse(id=1902020, encodeId=d3b61902020de, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sat Dec 29 15:04:00 CST 2018, time=2018-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638486, encodeId=b8f41638486a5, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, 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encodeId=54b329663448, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Fri Mar 16 06:11:14 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296632, encodeId=c667296632fe, content=学习糖尿病并发症, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Fri Mar 16 05:57:35 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296552, encodeId=702f2965521c, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Mar 15 22:00:12 CST 2018, time=2018-03-15, status=1, ipAttribution=)]
    2018-03-16 121832a9m88暂无昵称

    学习了

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1902020, encodeId=d3b61902020de, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sat Dec 29 15:04:00 CST 2018, time=2018-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638486, encodeId=b8f41638486a5, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat May 05 02:04:00 CST 2018, time=2018-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760583, encodeId=9dd91e60583b7, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Nov 16 16:04:00 CST 2018, time=2018-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407231, encodeId=3b5c140e23180, content=<a href='/topic/show?id=dc4b26688c5' target=_blank style='color:#2F92EE;'>#体重减轻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84458, encryptionId=13458445884, topicName=脆性骨折)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2f046959894, createdName=LSJ113, createdTime=Fri Mar 16 15:04:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474460, encodeId=1a5a14e446046, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Mar 16 15:04:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296634, 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channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Mar 15 22:00:12 CST 2018, time=2018-03-15, status=1, ipAttribution=)]
    2018-03-16 flysky120

    学习糖尿病并发症

    0

  10. 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channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Mar 15 22:00:12 CST 2018, time=2018-03-15, status=1, ipAttribution=)]
    2018-03-15 惠映实验室

    学习了.谢谢分享.

    0

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