Alzheimer&Dementia：真实世界研究提示这些血浆标志物对老年痴呆和相关痴呆症风险有早期识别作用

2023-03-16 MedSci原创 MedSci原创发表于上海

异常的血浆Aβ42/40比率确定了记忆力评分较低、痴呆风险较高和ADRD生物标志物水平较高的老年人群，对人群筛查有潜在意义。

阿尔茨海默病（AD）的特征是大脑中淀粉样β（Aβ）斑块和tau神经纤维缠结的沉积。其他病理生理特征包括神经变性/轴损伤和胶质激活。虽然大脑Aβ、tau、神经变性和胶质激活可通过既定的神经影像和脑脊液（CSF）生物标志物在体内进行量化，它们高昂的成本和有限的可用性阻碍了人群层面的应用。

血浆生物标志物是AD和相关疾病（ADRD）的低成本、非侵入性指标，主要在临床研究环境中进行研究。在此，来自匹兹堡大学的研究人员探讨了基于人群的队列中的血浆生物标志物概况及其相关因素，以确定它们是否能独立于大脑和脑脊液生物标志物来识别高危人群。

研究人员测量了宾夕法尼亚州西南部人口队列中847名参与者的血浆磷酸化tau181（p-tau181）、神经丝轻链（NfL）、胶质纤维酸性蛋白（GFAP）和淀粉样β（Aβ）42/40比率。

结果显示，K-medoids聚类确定了两种不同的血浆Aβ42/40模式，可进一步分为三个生物标志物谱组：正常、不确定和异常。在不同的组别中，血浆p-tau181、NfL和GFAP与Aβ42/40、临床痴呆评级和记忆综合评分呈反比，其中异常组的关联性最强。

在CDR=0的个体中，血浆NfL和GFAP分别与正常Aβ42/40组的记忆综合得分呈正相关。在异常Aβ42/40组中，血浆p-tau181与记忆综合评分呈反比关系。

由此可见，异常的血浆Aβ42/40比率确定了记忆力评分较低、痴呆风险较高和ADRD生物标志物水平较高的老年人群，对人群筛查有潜在意义。

参考文献：

Plasma biomarkers identify older adults at risk of Alzheimer's disease and related dementias in a real-world population-based cohort. https://doi.org/10.1002/alz.12986

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2023-03-17 ms1000000413528422 来自甘肃省

学习了

127 0
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2023-03-17 1013100771 来自山东省

学习了

122 0
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2023-03-17 ms1000000137130300 来自河北省

学习收获很大

119 0
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2023-03-17 永梦一人

学习了

130 0
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2023-03-17 筱皮医来自江苏省

学习

128 0
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2023-03-17 jshbyywk2008 来自河北省

真实世界研究

80 0
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2023-03-17 ms2000000136246308 来自广东省

学习了，很不错

69 0
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2023-03-16 ms4000000512201075

不错，学习了。

71 0

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