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Gut Liver:Daclatasvir联合Asunaprevir治疗HCV基因1b型患者的疗效和安全性

2018-02-11 MedSci MedSci原创

研究结论:DCV联合ASV治疗获得了较高的SVR12,并改善了患者肝纤维化程度;联合治疗在基因1b型丙型肝炎病毒感染患者中,治疗效果良好。

研究背景:Daclatasvir联合asunaprevir(DCV+ASV)在治疗HCV 1b型患者,有强大的抗病毒作用。本研究的目的是在韩国HCV基因1b患者中探讨DCV+ASV治疗的真实效果和作用。

研究方法:本研究纳入2015年8月至2017年1月,采用DCV联合ASV治疗的363例HCV患者。本研究最终纳入治疗结束后,随访12周的270例患者。

研究结果:270例患者的平均年龄为60.7岁,女性患者占总人数的60.4%。64.8%的患者为初治患者,56例患者(20.7%)为肝硬化患者。257例患者(95.2%)和251例患者(93.0%)分别获得了结束后治疗反应和治疗后12周可持续病毒学反应(SVR12)。年龄为65岁、男性、无肝硬化、HCV RNA载量较低的患者SVR12反应率较高。基线肝硬化指数和fibrosis-4以及天冬氨酸氨基转移酶/血小板指数到SVR12评估时间时,指数都减低了。

研究结论:DCV联合ASV治疗获得了较高的SVR12,并改善了患者肝纤维化程度;联合治疗在基因1b型丙型肝炎病毒感染患者中,治疗效果良好。

原始出处

Lee HW, Oh SR, Kim DY, et al. Daclatasvir Plus Asunaprevir for the Treatment of Patients with Hepatitis C Virus Genotype 1b Infection: Real-World Efficacy, Changes in Liver Stiffness and Fibrosis Markers, and Safety. Gut Liver, 2018, Feb 8. doi: 10.5009/gnl17298.

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    2018-02-13 ymljack
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    2018-02-13 bbjsj_1981
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