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Photodiagnosis Photodyn Ther:光动力治疗设备与皮肤接触与否都可安全治疗光化性角化病

2022-04-11 sunshine MedSci原创

光化性角化病是一种前期恶性皮肤病变,主要出现在头皮、面部、颈部和上肢等暴露于阳光的部位。局部光动力疗法是治疗散发型光化病的有效方法,但是疼痛是治疗中经常出现的不良事件,可能会影响患者对治疗的接受度。

光化性角化病是一种前期恶性皮肤病变,主要出现在头皮、面部、颈部和上肢等暴露于阳光的部位。局部光动力疗法是治疗散发型光化病的有效方法,但是疼痛是光动力疗法中经常出现的不良事件,可能会影响患者对治疗的接受度。近日,发表于Photodiagnosis Photodyn Ther的一项随机对照研究评估了面部和头皮光化性角化病患者采用两种照射方案进行光动力治疗时的疗效和疼痛。

在这项左右侧脸随机对照试验中,研究人员将参与者的左右侧面部随机分配接受方案1(照射设备与皮肤接触)和方案2(设备离皮肤3厘米)的氨基乙酰丙酸甲酯和红光的光动力疗法。两种方案之间有15天的间隔洗脱期。主要结果是光动力疗法期间中度或重度疼痛的平均强度频率。次要结果是光化性角化病清除率、原卟啉IX消耗量、参与者的偏好、皮肤外观和不良事件。

 

结果,研究共纳入了41名参与者,方案1和方案2分别产生了47和50个随机点。治疗结果显示,中度和重度疼痛的频率没有差异,相对风险为1.09(95% CI 0.70-1.70),P>0.05。在两种方案中都观察到光化性角化病数量减少>60%(P<0.01),但是两者之间没有差异。原卟啉IX的消耗量没有差异。大多数治疗部位的质量良好至优秀。患者方面,更倾向于方案2(P<0.01)。

综上所述,该研究结果表明,两种方案的疼痛强度相似,两种方案在清除日光性角化病、原卟啉IX消耗和改善治疗部位的质量方面同样有效。因此,两种方案都可以认为治疗光化性角化病是安全的。

 

原始出处:

 

Oliveira Er, et al., Randomized controlled trial for evaluation of efficacy and pain during photodynamic therapy for actinic keratosis of face and scalp comparing two irradiation protocols. Photodiagnosis Photodyn Ther. 2022 Mar;37:102623. doi: 10.1016/j.pdpdt.2021.102623.  

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    2023-01-23 liuxiaona
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  7. [GetPortalCommentsPageByObjectIdResponse(id=1648844, encodeId=7d6116488444a, content=<a href='/topic/show?id=d7a328e40fd' target=_blank style='color:#2F92EE;'>#光化性角化病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28740, encryptionId=d7a328e40fd, topicName=光化性角化病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a8a23689373, createdName=jinweidong, createdTime=Sat Dec 24 06:06:06 CST 2022, time=2022-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1719563, encodeId=74901e19563b0, content=<a href='/topic/show?id=404928e34f6' target=_blank style='color:#2F92EE;'>#光动力治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28734, encryptionId=404928e34f6, topicName=光动力治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c432763729, createdName=wshxjq, createdTime=Fri Nov 18 17:06:06 CST 2022, time=2022-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640112, encodeId=6425164011250, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sun Nov 20 23:06:06 CST 2022, time=2022-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788740, encodeId=d4531e887404c, content=<a href='/topic/show?id=ce4314201f3' target=_blank style='color:#2F92EE;'>#photo#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14201, encryptionId=ce4314201f3, topicName=photo)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cb3a261, createdName=liuxiaona, createdTime=Mon Jan 23 01:06:06 CST 2023, time=2023-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2054930, encodeId=481e2054930be, content=<a href='/topic/show?id=e2365922f4' target=_blank style='color:#2F92EE;'>#diagnosis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5922, encryptionId=e2365922f4, topicName=diagnosis)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c932500160, createdName=ms7421025882867189, createdTime=Sat Aug 27 08:06:06 CST 2022, time=2022-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546344, encodeId=955b1546344e3, content=<a href='/topic/show?id=0da528e33ce' target=_blank style='color:#2F92EE;'>#光动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28733, encryptionId=0da528e33ce, topicName=光动力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Tue Apr 12 06:06:06 CST 2022, time=2022-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623602, encodeId=73d61623602ba, content=<a href='/topic/show?id=a323909163b' target=_blank style='color:#2F92EE;'>#角化病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90916, encryptionId=a323909163b, topicName=角化病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10a720562694, createdName=guihongzh, createdTime=Tue Apr 12 06:06:06 CST 2022, time=2022-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1210318, encodeId=14a8121031802, content=好东西,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d0be2111725, createdName=萌宝嘟嘟, createdTime=Mon Apr 11 17:15:44 CST 2022, time=2022-04-11, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1648844, encodeId=7d6116488444a, content=<a href='/topic/show?id=d7a328e40fd' target=_blank style='color:#2F92EE;'>#光化性角化病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28740, encryptionId=d7a328e40fd, topicName=光化性角化病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a8a23689373, createdName=jinweidong, createdTime=Sat Dec 24 06:06:06 CST 2022, time=2022-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1719563, encodeId=74901e19563b0, content=<a href='/topic/show?id=404928e34f6' target=_blank style='color:#2F92EE;'>#光动力治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28734, encryptionId=404928e34f6, topicName=光动力治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c432763729, createdName=wshxjq, createdTime=Fri Nov 18 17:06:06 CST 2022, time=2022-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640112, encodeId=6425164011250, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sun Nov 20 23:06:06 CST 2022, time=2022-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788740, encodeId=d4531e887404c, content=<a href='/topic/show?id=ce4314201f3' target=_blank style='color:#2F92EE;'>#photo#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14201, encryptionId=ce4314201f3, topicName=photo)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cb3a261, createdName=liuxiaona, createdTime=Mon Jan 23 01:06:06 CST 2023, time=2023-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2054930, encodeId=481e2054930be, content=<a href='/topic/show?id=e2365922f4' target=_blank style='color:#2F92EE;'>#diagnosis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5922, encryptionId=e2365922f4, topicName=diagnosis)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c932500160, createdName=ms7421025882867189, createdTime=Sat Aug 27 08:06:06 CST 2022, time=2022-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546344, encodeId=955b1546344e3, content=<a href='/topic/show?id=0da528e33ce' target=_blank style='color:#2F92EE;'>#光动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28733, encryptionId=0da528e33ce, topicName=光动力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Tue Apr 12 06:06:06 CST 2022, time=2022-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623602, encodeId=73d61623602ba, content=<a href='/topic/show?id=a323909163b' target=_blank style='color:#2F92EE;'>#角化病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90916, encryptionId=a323909163b, topicName=角化病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10a720562694, createdName=guihongzh, createdTime=Tue Apr 12 06:06:06 CST 2022, time=2022-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1210318, encodeId=14a8121031802, content=好东西,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d0be2111725, createdName=萌宝嘟嘟, createdTime=Mon Apr 11 17:15:44 CST 2022, time=2022-04-11, status=1, ipAttribution=)]
    2022-04-11 萌宝嘟嘟

    好东西,谢谢分享

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