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Biomed Pharmacother:葡萄籽来源的多酚对镉诱导的前列腺功能缺陷潜在的益处

2017-05-23 AlexYang MedSci原创

葡萄被人们当作水果消费或者制成酒类饮品。最近,有研究人员通过为期20周的饮水方式,对小鼠模型口服60mg/L的CdCl2来诱导产生前列腺功能缺陷。并且,研究人员同样对小鼠进行为期20周的葡萄籽来源的多酚(GSP)口服试验。最后,研究人员通过多免疫组化和qPCR分析对前列腺的钙黏蛋白、纤连蛋白和平滑肌动蛋白的水平进行了测量。另外,研究人员通过检测丙二醛、一氧化氮、还原型谷胱甘肽/氧化型谷胱甘肽和酶促

葡萄被人们当作水果消费或者制成酒类饮品。最近,有研究人员通过为期20周的饮水方式,对小鼠模型口服60mg/L的CdCl2来诱导产生前列腺功能缺陷。并且,研究人员同样对小鼠进行为期20周的葡萄籽来源的多酚(GSP)口服试验。最后,研究人员通过多免疫组化和qPCR分析对前列腺的钙黏蛋白、纤连蛋白和平滑肌动蛋白的水平进行了测量。另外,研究人员通过检测丙二醛、一氧化氮、还原型谷胱甘肽/氧化型谷胱甘肽和酶促抗氧化状态来检测氧化压力。还有,研究人员通过蛋白免疫印迹方法检测了转变生长因子-β1(TGF-β1)、类型I TGF-β受体、Smad3、磷酸化Smad3(p-Smad3)、Smad7、核相关因子2(Nrf-2)、血红素氧化酶-1(HO-1)和γ-谷氨酸半胱氨酸催化亚基(γ-GCLC)的前列腺表达情况。并利用qPCR方法检测了microRNA(miR)-133a/b的水平。

研究结果发现,GSP改善了CdCl2诱导的前列腺氧化压力和纤维化。GSP同样抑制了TGF-β1和p-Smad3的过度产生,同时提高了Smad7, Nrf-2, HO-1, γ-GCLC 和 miR-133a/b的水平。最后,研究人员指出,这些结果表明了GSP可以改善镉诱导的前列腺功能缺陷。

原始出处:


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    2018-02-03 yb6560
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    2018-02-27 jj000001
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    2017-10-11 sunylz
  5. [GetPortalCommentsPageByObjectIdResponse(id=1995987, encodeId=b18e199598ed6, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Sat Feb 03 23:41:00 CST 2018, time=2018-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1908260, encodeId=3c1b19082600b, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Thu Jan 18 00:41:00 CST 2018, time=2018-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787256, encodeId=0f611e872568a, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Tue Feb 27 07:41:00 CST 2018, time=2018-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917496, encodeId=c8d1191e49679, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Oct 11 10:41:00 CST 2017, time=2017-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1737282, encodeId=867d1e37282db, content=<a href='/topic/show?id=95138823960' target=_blank style='color:#2F92EE;'>#葡萄籽#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88239, encryptionId=95138823960, topicName=葡萄籽)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dfc734274666, createdName=12498568m61暂无昵称, createdTime=Thu Mar 29 22:41:00 CST 2018, time=2018-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532563, encodeId=2df31532563ad, content=<a href='/topic/show?id=e28e968202e' target=_blank style='color:#2F92EE;'>#镉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96820, encryptionId=e28e968202e, topicName=镉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0b0612361712, createdName=shock_melon, createdTime=Thu May 25 12:41:00 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607551, encodeId=9172160e55137, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu May 25 12:41:00 CST 2017, time=2017-05-25, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1995987, encodeId=b18e199598ed6, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Sat Feb 03 23:41:00 CST 2018, time=2018-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1908260, encodeId=3c1b19082600b, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Thu Jan 18 00:41:00 CST 2018, time=2018-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787256, encodeId=0f611e872568a, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Tue Feb 27 07:41:00 CST 2018, time=2018-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917496, encodeId=c8d1191e49679, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Oct 11 10:41:00 CST 2017, time=2017-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1737282, encodeId=867d1e37282db, content=<a href='/topic/show?id=95138823960' target=_blank style='color:#2F92EE;'>#葡萄籽#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88239, encryptionId=95138823960, topicName=葡萄籽)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dfc734274666, createdName=12498568m61暂无昵称, createdTime=Thu Mar 29 22:41:00 CST 2018, time=2018-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532563, encodeId=2df31532563ad, content=<a href='/topic/show?id=e28e968202e' target=_blank style='color:#2F92EE;'>#镉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96820, encryptionId=e28e968202e, topicName=镉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0b0612361712, createdName=shock_melon, createdTime=Thu May 25 12:41:00 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607551, encodeId=9172160e55137, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu May 25 12:41:00 CST 2017, time=2017-05-25, status=1, ipAttribution=)]
    2017-05-25 shock_melon
  7. [GetPortalCommentsPageByObjectIdResponse(id=1995987, encodeId=b18e199598ed6, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Sat Feb 03 23:41:00 CST 2018, time=2018-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1908260, encodeId=3c1b19082600b, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Thu Jan 18 00:41:00 CST 2018, time=2018-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787256, encodeId=0f611e872568a, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Tue Feb 27 07:41:00 CST 2018, time=2018-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917496, encodeId=c8d1191e49679, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Oct 11 10:41:00 CST 2017, time=2017-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1737282, encodeId=867d1e37282db, content=<a href='/topic/show?id=95138823960' target=_blank style='color:#2F92EE;'>#葡萄籽#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88239, encryptionId=95138823960, topicName=葡萄籽)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dfc734274666, createdName=12498568m61暂无昵称, createdTime=Thu Mar 29 22:41:00 CST 2018, time=2018-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532563, encodeId=2df31532563ad, content=<a href='/topic/show?id=e28e968202e' target=_blank style='color:#2F92EE;'>#镉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96820, encryptionId=e28e968202e, topicName=镉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0b0612361712, createdName=shock_melon, createdTime=Thu May 25 12:41:00 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607551, encodeId=9172160e55137, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu May 25 12:41:00 CST 2017, time=2017-05-25, status=1, ipAttribution=)]

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