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Diabetologia:注意了!熬夜、睡眠质量差,血糖波动大!

2021-12-16 MedSci原创 MedSci原创

睡眠效率差和较晚的就寝时间与次日早晨对早餐的餐后血糖更高有关。

饮食、身体活动和睡眠越来越被认为是健康生活方式中可改变的核心组成部分。睡眠障碍常常与其他健康疾病一起出现,并以这种方式提供总体健康的晴雨表。睡眠对许多威胁生命的疾病有直接的因果关系,如心血管疾病、肥胖症和2型糖尿病

睡眠障碍(如阻塞性睡眠呼吸暂停)与2型糖尿病的发病率和并发症有关,并能破坏葡萄糖的平衡。这些数据和其他数据指出,睡眠质量/时间与葡萄糖平衡之间存在着密切的联系。然而,虽然有许多大型前瞻性队列研究关注自我报告的睡眠、疾病和健康之间的关系,但关于睡眠和餐后葡萄糖代谢的证据仍不足。

为了探讨睡眠质量、睡眠时长、入睡时间与第二天早餐后的血糖水平之间的关系,瑞典马尔默隆德大学临床科学系隆德大学糖尿病中心遗传与分子流行病学专家开展了相关研究,结果发表在《糖尿病学》(Diabetologia)杂志上。

健康成年人的数据(N=953[41%为双胞胎])来自PREDICT饮食干预试验的分析。参与者在诊所和家中食用了2周的等能量标准化膳食。用行为图谱来评估睡眠变量(持续时间、效率、时间),用连续血糖监测仪来测量血糖变化(>8000餐)。

睡眠变量与餐后血糖控制(2小时增量AUC)在人与人之间和人与人之间的水平上都有显著关联。睡眠时间与膳食类型相互作用,与参考的75克OGTT(对照组)相比,当食用高碳水化合物(低脂肪/蛋白质)和高脂肪早餐时,睡眠不足对餐后血糖水平的影响较小。

同时,与其他参与者相比,即便吃了高碳水化合物和高脂肪早餐,如果前一天睡眠时间较长,第二天餐后血糖更低。睡眠时长于饮食类型有类似的相互作用(高碳水化合物:相互作用=0.001,高脂肪:相互作用=0.02)。

此外,同一参与者,不论膳食类型,睡眠效率与餐后血糖水平明显相关(均为p < 0.03)。如果参与者的睡眠时间比平时更长,第2天吃了高碳水化合物或高脂肪早餐后,餐后血糖可能会降低(分别为p = 0.035和p = 0.051)。

综上,睡眠效率差和较晚的就寝时间与次日早晨对早餐的餐后血糖更高有关。一个人偏离其通常的睡眠模式也与较差的餐后血糖控制有关。这些发现强调了睡眠是一个可改变的、非药物治疗的目标,以优化调节人类的代谢健康。

 

参考文献:

Tsereteli, N., Vallat, R., Fernandez-Tajes, J. et al. Impact of insufficient sleep on dysregulated blood glucose control under standardised meal conditions. Diabetologia (2021). https://doi.org/10.1007/s00125-021-05608-y

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    2021-12-28 ms1000000251410274

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    2021-12-17 星痕

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