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DIABETOLOGIA:吸烟对1型糖尿病患者冠心病,心力衰竭和中风风险的剂量依赖性影响如何?

2018-12-02 MedSci MedSci原创

本研究的目的是评估吸烟对1型糖尿病患者冠心病,心力衰竭和中风风险的潜在剂量依赖性影响。该研究包括4506名参与芬兰糖尿病肾病(FinnDiane)研究的1型糖尿病患者。吸烟强度按每天每包计算,累计吸烟按包每年计算。采用Cox回归分析评估随访期间发生冠心病,心力衰竭或中风的风险。 结果显示,在校正年龄,性别,HbA 1c,高血压,糖尿病持续时间和BMI 后,每天一包吸烟量会显著增加吸烟者与不吸

本研究的目的是评估吸烟对1糖尿病患者冠心病,心力衰竭和中风风险的潜在剂量依赖性影响。该研究包括4506名参与芬兰糖尿病肾病(FinnDiane)研究的1糖尿病患者。吸烟强度按每天每包计算,累计吸烟按包每年计算。采用Cox回归分析评估随访期间发生冠心病,心力衰竭或中风的风险。

结果显示,在校正年龄,性别,HbA 1c高血压,糖尿病持续时间和BMI 后,每天一包吸烟量会显著增加吸烟者与不吸烟者相比患CHD的风险(HR 1.45 [95CI 1.15,1.84])。以前吸烟者患冠心病的风险与从不吸烟者的风险相似。当前吸烟者每天每包吸烟的风险为1.4395CI 1.03,1.97),以前吸烟者为1.3795CI 1.05,1.77),而卒中发生的风险分别为1.7095CI)分别为1.26,2.29)和1.4995CI 1.14,1.93)。然而,在进一步校正脂质后,当前和以前吸烟者心力衰竭风险的差异不再显著。累积吸烟数据与吸烟强度数据相似。

1型糖尿病患者的吸烟与血管疾病之间存在剂量依赖关系。特别是在男性中,即使戒烟后卒中风险仍然很高,并且在当前和以前的吸烟者中,独立于其他危险因素,分险也会升高。

原始出处:

Maija FeodoroffValma HarjutsaloCarol Forsblom, Dose-dependent effect of smoking on risk of coronary heart disease, heart failure and stroke in individuals with type 1 diabetes

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    2018-12-03 misszhang

    谢谢MedSci提供最新的资讯

    0

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    2018-12-03 guging

    中风是俗称,应该称为缺血性卒中吧

    0

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