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Eur Respir J:肺动脉高压患者的社会剥夺与预后分析!

2018-02-02 xing.T MedSci原创

由此可见,社会剥夺并不是IPAH和HPAH患者一个重要的转诊障碍和预后因素。

几个人口学指标和临床因素对特发性肺动脉高压(IPAH)具有预后意义。在中国和美国的研究表明,较低的社会经济地位与生存率降低之间存在相关性。但是,社会剥夺对英国IPAH患者生存的影响尚不清楚。近日,呼吸疾病领域权威杂志Eur Respir J上针对这一问题发表了一篇研究文章。

研究人员利用苏格兰多重剥夺索引数据库将280例参与苏格兰肺血管单元(格拉斯哥、英国)的IPAH患者和遗传性PAH(HPAH)患者分配到社会剥夺五分位数组。采用Cox比例风险回归分析评估了生存和社会剥夺五分位数之间的关联。

IPAH/HPAH患者更多地分布于社会剥夺,相比于基于苏格兰公民的整体预期(卡方值为16.16,P=0.003),提示转诊和获取保健不受社会经济地位的影响。单因素分析显示社会剥夺和生存率之间没有显著的相关性(P=0.81),而这种关联在包含了时间、性别和年龄作为协变量的模型中也是没有意义的(P=0.23)。除年龄、性别和生活质量外,社会剥夺与预测预后的基线临床变量之间的相关性无统计学意义。

由此可见,社会剥夺并不是IPAH和HPAH患者一个重要的转诊障碍和预后因素。

原始出处:

Katherine Pellino,et al. Social deprivation and prognosis in Scottish patients with pulmonary arterial hypertension.Eur Respir J. http://erj.ersjournals.com/content/51/2/1700444

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    2018-02-02 明天jing

    肺动脉高压表面是罕见病,事实上临床上并不少见,治疗药物虽然有一些,但是整体仍然不理解,可能未来需要采用综合治疗措施。

    0

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