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Neurology:自体造血干细胞移植治疗多发性硬化

2017-04-29 zhangfan MedSci原创

自体造血干细胞移植免疫清除治疗可以有效缓解重度多发性硬化患者病情降低致残率提高患者生活质量

近日研究人员总结了自体造血干细胞移植免疫清除治疗在严重难治性多发性硬化患者(MS)中的应用。

研究人员收集了1995年至2016年严重难治性多发性硬化治疗的研究报道,研究的终点为移植相关死亡率(TRM),疾病进展的速度以及无证据疾病活动(EDA)状态。利用泊松模型加权回归模型评估研究特征对移植相关死亡率以及病情进展的影响。

共有15项报道涉及764名患者纳入本次研究。总的移植相关死亡率为2.1%(95%  CI 1.3%-3.4%),对于老年以及复发缓解型多发性硬化患者(RRMS)移植相关死亡率较高(p = 0.014,p = 0.028),残疾状态基线指数较高患者其移植相关死亡率显著提高;2年和5年的疾病进展率分别为17.1%和23.3%;复发缓解型多发性硬化患者出现2年内病情进展的可能性较大(p = 0.004)。2年以及5年的无证据疾病活动状态率分别为83%和67%。

研究表明,自体造血干细胞移植免疫清除治疗可以有效缓解重度多发性硬化患者病情降低致残率提高患者生活质量。

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    2017-12-04 yinhl1978
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    2017-07-21 jml2009
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    2017-05-23 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

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    2017-04-30 俅侠
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    2017-04-29 lyh994

    生命是个非常奥秘的东西,承载了太多秘密

    0

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