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JACC:心肌灌注定量可预测有冠脉搭桥术史的患者心脏血管不良结局风险

2022-03-29 MedSci原创 MedSci原创

整体应激心肌血流量和灌注储备量可独立预测既往进行过冠状动脉搭桥手术的患者的心脏血管不良预后风险

既往有冠状动脉搭桥 (CABG) 手术经历的患者通常有较为复杂的冠状动脉疾病,并且有很高的不良事件风险。已有研究显示,心肌灌注定量指标可预测血管疾病的预后,但它们在既往有CABG手术经历的患者中的预后表现尚不清楚。

在本研究中,研究人员评估了通过心脏磁共振(CMR)灌注检查获得的整体应激心肌血流量(MBF)和灌注储备量(MPR)是否可独立预测既往有CABG手术经历的患者的不良结局。

心肌灌注评估

这是一项回顾性分析,纳入了有CABG手术史且进行了腺苷应激灌注CMR检查的患者。灌注测图与MBF自动定量同步进行。主要终点是全因死亡和主要不良心血管事件(包括非致死性心肌梗死和非计划的血运重建)的复合结局。

根据MPR值分组的患者的无事件生存率

共纳入了341位患者,中位年龄67岁,86%的男性。中位随访了638天之后,81位(24%)患者达到了主要终点。根据已知的预后因素(局部缺血、梗死)调整后,应激MBF和MPR均可独立预测预后。应激MBF每降低1mg/g/min发生主要终点的风险比为2.56,而MPR每降低1个单位发生主要终点的风险比为1.61。

根据应激MBF分组的患者的无事件生产率

 

综上所述,通过心脏磁共振检查获得的整体应激心肌血流量和灌注储备量可独立预测既往进行过冠状动脉搭桥手术的患者的心脏血管不良预后风险。这种预测效果不受视觉评估的局部缺血的存在与否和既往梗死的程度的影响。

 

原始出处:

Seraphim Andreas,Dowsing Benjamin,Rathod Krishnaraj S et al. Quantitative Myocardial Perfusion Predicts Outcomes in Patients With Prior Surgical?Revascularization.[J] .J Am Coll Cardiol, 2022, 79: 1141-1151. https://doi.org/10.1016/j.jacc.2021.12.037.

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    2022-05-25 hbwxf
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    2022-03-30 zzc2214
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    2022-03-30 yese
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    2022-03-29 医鸣惊人

    认真学习了

    0

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