Baidu
map

Int Arch Allergy Immunol:钙调蛋白调控人类鼻粘膜的纤毛摆动

2021-05-09 AlexYang MedSci原创

包括鼻窦上皮在内的气道上皮的纤毛摆动在一线防御中具有重要作用,并认为是由细胞内的Ca2+水平控制的。据报道,钙调蛋白和腺苷酸/鸟苷酸环化酶参与了纤毛摆动调节。

包括鼻窦上皮在内的气道上皮的纤毛摆动在一线防御中具有重要作用,并认为是由细胞内的Ca2+水平控制的。据报道,钙调蛋白和腺苷酸/鸟苷酸环化酶参与了纤毛摆动调节。

最近,有研究人员调查了纤毛摆动调控途径中这些成分之间的相互关系

研究人员在内窥镜鼻腔手术中收集了29名慢性肥厚性鼻炎/鼻窦炎患者的下鼻甲。将鼻甲粘膜切成薄片,在装有高速数码摄像机的相位对比光镜下观察粘膜纤毛运动。研究结果发现,用100μM CALP3(钙调蛋白激动剂)刺激时,纤毛摆动频率(CBF)明显增加,而同时加入100μM SQ22536(腺苷酸环化酶抑制剂)和10μM ODQ(鸟苷酸环化酶抑制剂)以及同时加入1μM KT5720(蛋白激酶A抑制剂)和1μM KT5823(蛋白激酶G抑制剂)则被完全抑制。用10 ?M forskolin(腺苷酸环化酶激活剂)和10 ?M BAY41-2272(鸟苷酸环化酶激活剂)刺激,以及用100 ?M 8-溴-cAMP(cAMP类似物)和100 ?M 8-溴-cGMP(cGMP类似物)刺激时,CBF明显增加,加入1 ?M calidazolium(钙调蛋白拮抗剂)时没有发生改变。

钙调蛋白激动剂和蛋白激酶A和G抑制剂对CBF的影响

最后,研究人员指出,人类鼻粘膜纤毛摆动的调节途径涉及钙调蛋白、腺苷酸/鸟苷酸环化酶和蛋白激酶A/G。腺苷酸/鸟苷酸环化酶和蛋白激酶A/G作用于钙调蛋白的下游,并进一步传递钙调蛋白信号

原始出处:

Thi Nga Nguyen, Hideaki Suzuki, Jun-Ichi Ohkubo. Calmodulin Regulates Ciliary Beats in the Human Nasal Mucosa Through Adenylate/Guanylate Cyclases and Protein Kinases A/G. Int Arch Allergy Immunol. Apr 2021

 

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (3)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1994945, encodeId=0471199494596, content=<a href='/topic/show?id=3a05103496c1' target=_blank style='color:#2F92EE;'>#鼻粘膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103496, encryptionId=3a05103496c1, topicName=鼻粘膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04d6114, createdName=jml2009, createdTime=Fri Aug 20 15:42:06 CST 2021, time=2021-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1691092, encodeId=eda716910926a, content=<a href='/topic/show?id=7adce62603e' target=_blank style='color:#2F92EE;'>#粘膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76260, encryptionId=7adce62603e, topicName=粘膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=090129165428, createdName=guoyibin, createdTime=Fri Dec 24 03:42:06 CST 2021, time=2021-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329499, encodeId=2ca213294996b, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Tue May 11 03:42:06 CST 2021, time=2021-05-11, status=1, ipAttribution=)]
    2021-08-20 jml2009
  2. [GetPortalCommentsPageByObjectIdResponse(id=1994945, encodeId=0471199494596, content=<a href='/topic/show?id=3a05103496c1' target=_blank style='color:#2F92EE;'>#鼻粘膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103496, encryptionId=3a05103496c1, topicName=鼻粘膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04d6114, createdName=jml2009, createdTime=Fri Aug 20 15:42:06 CST 2021, time=2021-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1691092, encodeId=eda716910926a, content=<a href='/topic/show?id=7adce62603e' target=_blank style='color:#2F92EE;'>#粘膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76260, encryptionId=7adce62603e, topicName=粘膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=090129165428, createdName=guoyibin, createdTime=Fri Dec 24 03:42:06 CST 2021, time=2021-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329499, encodeId=2ca213294996b, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Tue May 11 03:42:06 CST 2021, time=2021-05-11, status=1, ipAttribution=)]
    2021-12-24 guoyibin
  3. [GetPortalCommentsPageByObjectIdResponse(id=1994945, encodeId=0471199494596, content=<a href='/topic/show?id=3a05103496c1' target=_blank style='color:#2F92EE;'>#鼻粘膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103496, encryptionId=3a05103496c1, topicName=鼻粘膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04d6114, createdName=jml2009, createdTime=Fri Aug 20 15:42:06 CST 2021, time=2021-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1691092, encodeId=eda716910926a, content=<a href='/topic/show?id=7adce62603e' target=_blank style='color:#2F92EE;'>#粘膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76260, encryptionId=7adce62603e, topicName=粘膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=090129165428, createdName=guoyibin, createdTime=Fri Dec 24 03:42:06 CST 2021, time=2021-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329499, encodeId=2ca213294996b, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Tue May 11 03:42:06 CST 2021, time=2021-05-11, status=1, ipAttribution=)]
    2021-05-11 膀胱癌

相关资讯

Allergy:鼻内皮质激素治疗对2型先天淋巴细胞的影响研究

过敏性鼻炎具有鼻出血、鼻塞、打喷嚏和鼻腔瘙痒的特征。鼻腔过敏原挑战(NAC)后,鼻黏膜中的2型先天淋巴细胞(ILC2s)、CD4+T细胞和嗜酸性粒细胞均显著增加。但鼻腔内皮质激素(INCS)对ILC2

J Asthma Allergy:鼻腔一氧化氮和主动性前鼻测压在诊断过敏性鼻炎和哮喘中的作用

过敏性鼻炎(AR)和哮喘是两种常见的特应性疾病,通常存在共同的发病机制,其特点是Th2炎症反应与许多生物标志物的释放,如一氧化氮(NO)。

盘点:近期鼻炎与治疗进展(六)

【1】ORL J Otorhinolaryngol Relat Spec:鼻腔细胞学在射频鼻甲缩小术中的应用

J Allergy Clin Immunol:猫尾草皮下和舌下免疫疗法对过敏原特异性IgA反应的不同诱导作用

舌下免疫治疗(SLIT)和皮下免疫治疗(SCIT)后的过敏原特异性免疫球蛋白响应还没有详细比较。

盘点:近期鼻部疾病研究进展(六)

鼻炎即鼻腔炎性疾病,是病毒、细菌、变应原、各种理化因子以及某些全身性疾病引起的鼻腔黏膜的炎症。鼻炎的主要病理改变是鼻腔黏膜充血、肿胀、渗出、增生、萎缩或坏死等。梅斯医学小编整理了近期鼻炎相关的研究进展

Int Forum Allergy Rhinol:鼻炎疾病严重程度衡量的系统性回顾

鼻科医生经常会遇到各种过敏性鼻炎(AR)和非过敏性鼻炎(NAR)患者,他们可以根据疾病的时间和严重程度进行不同的分类。人们对不同分类的鼻炎对生活质量(QOL)影响的理解是有限的。

Baidu
map
Baidu
map
Baidu
map