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Lancet Diabetes Endo:机器学习技术解锁2型糖尿病患者减肥的好处

2017-07-13 Heather_z727 来宝网

最新,发表于《柳叶刀》杂志上的文章表示,对于大部分2型糖尿病患者而言,减肥可以减少长期的心血管疾病风险,降低死亡率。但是对于少部分2型糖尿病患者而言,大幅减重会导致更加糟糕的结果。 在此次研究中,85%的研究样本显着,减重可以减少心血管死亡率和发病率。研究人员表示: “我们的分析表明,机器学习因果推论的最新进展可以增加临床相关研究的数量,作为研究人员和数据科学家,我们总是担心整体研究结果可能掩

最新,发表于《柳叶刀》杂志上的文章表示,对于大部分2型糖尿病患者而言,减肥可以减少长期的心血管疾病风险,降低死亡率。但是对于少部分2型糖尿病患者而言,大幅减重会导致更加糟糕的结果。

在此次研究中,85%的研究样本显着,减重可以减少心血管死亡率和发病率。研究人员表示:

“我们的分析表明,机器学习因果推论的最新进展可以增加临床相关研究的数量,作为研究人员和数据科学家,我们总是担心整体研究结果可能掩盖不同类型的患者的重大差异,然而机器研究能够识别个人,为患者提供个性化的护理。

“除了临床发现,这项工作显示了先进的机器学习方法对精密医学遗传学的积极作用。此次研究分析了5000多名超重和肥胖的糖尿病患者,随访13年。其目的是要确定,通过生活方式的适度减肥降低了死亡率和严重的心脏病以及中风风险。早期试验并没有发现两者之间的关系。

“在此次研究中,我们以数据科学和精密医学作为基本工具,数据分析结果显示,85%的2型糖尿病患者受益于体重适度减少,有效降低了心脏病等并发症的发病率,除此之外,也有15%的患者无法受益于减重。我们的研究结果虽然不适用于所有的糖尿病患者,但是,对于大多数糖尿病患者而言,通过健康的生活方式减轻体重还是大有益处的。”

原始出处:

Aaron Baum, Joseph Scarpa, et al. Targeting weight loss interventions to reduce cardiovascular complications of type 2 diabetes: a machine learning-based post-hoc analysis of heterogeneous treatment effects in the Look AHEAD trial.  The Lancet Diabetes & Endocrinology Published: 12 July 2017

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    2018-03-17 howi
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    2017-08-30 184****9840

    学习了谢谢分享

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    2017-08-28 184****9840

    学习了谢谢分享

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  6. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Wed Aug 16 22:13:03 CST 2017, time=2017-08-16, status=1, ipAttribution=)]
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    学习了谢谢分享

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    2017-08-24 130****4638

    学习了受益匪浅

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  8. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Wed Aug 16 22:13:03 CST 2017, time=2017-08-16, status=1, ipAttribution=)]
    2017-08-21 189****7206

    学习了谢谢分享

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  9. 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    2017-08-18 189****7206

    学习了谢谢分享

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  10. 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    2017-08-16 189****7206

    学习了受益匪浅

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几项高质量系统评价和荟萃分析已经评估了含糖饮料与2型糖尿病之间的相关性。2017年5月,发表在《CMAJ》的一项前瞻性研究的系统评价和荟萃分析,考察了糖、果糖和蔗糖与2型糖尿病之间的相关性。

Nutrition:2型糖尿病患者限盐并非** 这种情况下另当别论!

虽然钠葡萄糖协同转运蛋白2(SGLT2)抑制剂会增加钠排泄入尿中,但低钠血症仍然罕见,随之带来不良反应。2017年5月,发表在《Nutrition》的一项研究调查了2型糖尿病患者中,SGLT2抑制剂给药后,盐(钠离子)的摄入是否会影响血清钠水平。

J Gen Intern Med:研究揭示糖尿病患者反复住院的根本原因!

糖尿病是困扰全球的疾病,尤其是2型糖尿病患者的人数不断攀升。糖尿病的危险之处就在于由它引起的各种并发症。据调查,每年由于糖尿病入院的人数不在少数,而糖尿病患者的反复入院也是非常普遍的情况,在《普通内科医学》杂志上发表的文章表示,糖尿病患者反复入院的风险因素都与由血糖引起的各种并发症有关。

2型糖尿病合并动脉粥样硬化性心血管疾病患者降糖药物应用专家共识

动脉粥样硬化性心血管疾病(ASCVD) 包括冠心病、缺血性卒中及外周动脉疾病, 是2型糖尿病(T2DM) 患者致死和致残的主要原因。目前国内外糖尿病防治指南均推荐, 对于T2DM患者, 必须加强髙血糖、高血压、血脂异常、肥胖等多重心血管危险因素的综合管理, 以最大限度降低心血管事件和死亡风险。近年来, 由于美国FDA的强制性要求, 全球已完成或正在开展一系列新型降糖药物的心血管结局研究(CVOT)

Diabetes Care:2型糖尿病患者抗阻力训练中骨骼肌微血管参与改善血糖控制!

由此可见,RT可以改善OGC刺激的肌肉MBF和血糖控制,这表明MBF在RT改善的血糖控制发挥了作用。

Diabetes Obes Metab:二甲双胍预防胰岛素治疗2型糖尿病患者体重增加不能用减少能量摄入来解释!

由此可见,二甲双胍预防体重增加不能通过减少能量摄入来解释。

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