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Int Forum Allergy Rhinol:高组织嗜酸粒细胞水平可以作为预测嗜酸性慢性鼻窦炎复发的标记

2018-08-20 AlexYang MedSci原创

患有嗜酸性慢性鼻窦炎(ECRS)的患者在经历鼻窦手术之后都表现出了更大的疾病严重度和更差的治疗结果。尽管ECRS的炎症模式对诊断其亚型分类是必要的,但是到目前为止,在诊断方面还没有定论。最近,有研究人员确定了是否高组织嗜酸粒细胞(HTE)水平可以预测ECRS复发的可能性。研究人员在Embase、Medline和PubMed数据库中搜索了相关的研究,这些研究均报道了在外科手术后ECRS患者HTE和复

患有嗜酸性慢性鼻窦炎(ECRS)的患者在经历鼻窦手术之后都表现出了更大的疾病严重度和更差的治疗结果。尽管ECRS的炎症模式对诊断其亚型分类是必要的,但是到目前为止,在诊断方面还没有定论。最近,有研究人员确定了是否高组织嗜酸粒细胞(HTE)水平可以预测ECRS复发的可能性。

研究人员在Embase、Medline和PubMed数据库中搜索了相关的研究,这些研究均报道了在外科手术后ECRS患者HTE和复发情况。研究人员还利用随机效应二元分析推算了敏感性、特异性和诊断风险比(DOR)等参数。研究总共鉴定了11篇文献(n=3183),这些文献均报道了与复发相关的THE。研究发现,大于55 eos/HPF截断值的患者表现出了最高的敏感度(0.87,95%置信区间(CI),0.82-0.91)、特异性(0.97; 95% CI, 0.93-0.99)和DOR(232.7; 95% CI, 91.0-595.1)。元回归分析表明诊断准确性研究质量评估得分(p = 0.1287)、地理位置(p=0.3745)、跟踪调查时间(p=0.2879)和研究设计均不影响测试的准确性。

最后,研究人员指出,他们的研究表明了eos/HPF具有良好的诊断准确性,并且可能是鉴定ECRS患者的有用的工具。基于他们的元分析,研究人员提出,可以将截断值大于55 eos/HPF作为预测ECRS可能复发的指标。

原始出处:


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    2018-08-22 膀胱癌
  2. [GetPortalCommentsPageByObjectIdResponse(id=1329142, encodeId=760a132914266, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Wed Aug 22 13:23:00 CST 2018, time=2018-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351386, encodeId=80fb1351386c9, content=<a href='/topic/show?id=be7453e38d2' target=_blank style='color:#2F92EE;'>#慢性鼻窦炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53738, encryptionId=be7453e38d2, topicName=慢性鼻窦炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Aug 22 13:23:00 CST 2018, time=2018-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=340153, encodeId=087c34015334, content=很好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b2e1935437, createdName=AlexYang, createdTime=Wed Aug 22 13:08:52 CST 2018, time=2018-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=339820, encodeId=84aa33982036, content=不错的文章值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon Aug 20 23:22:18 CST 2018, time=2018-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=339800, encodeId=3ba933980011, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon Aug 20 22:33:21 CST 2018, time=2018-08-20, status=1, ipAttribution=)]
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    2018-08-22 AlexYang

    很好!

    0

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    2018-08-20 131****2916

    不错的文章值得推荐一下

    0

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    2018-08-20 惠映实验室

    学习了,谢谢分享。

    0

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