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Lancet diabetes endo:备孕期间补充维生素D,可增加受孕、改善妊娠结局!

2018-06-01 MedSci MedSci原创

妊娠期维生素D缺乏与不良妊娠结局相关,但孕前维生素D浓度与活产间的关系尚不明确。Sunni L Mumford等人对孕前维生素D浓度和妊娠结局之间的关联进行评估。研究人员对分组随机、双盲、安慰剂对照的EAGeR试验的前瞻性队列进行二次分析。本研究人群为2007年6月15日-2011年7月15日间在美国4个临床中心招募的18-40岁的有1-2次流产史的女性。在尝试怀孕期间随访长达6个月经周期,若妊娠

妊娠期维生素D缺乏与不良妊娠结局相关,但孕前维生素D浓度与活产间的关系尚不明确。Sunni L Mumford等人对孕前维生素D浓度和妊娠结局之间的关联进行评估。

研究人员对分组随机、双盲、安慰剂对照的EAGeR试验的前瞻性队列进行二次分析。本研究人群为2007年6月15日-2011年7月15日间在美国4个临床中心招募的18-40岁的有1-2次流产史的女性。在尝试怀孕期间随访长达6个月经周期,若妊娠则随访整个孕期。于起始(孕前)和孕8周时检测血清25-羟基维生素D浓度。评估结点:临床妊娠、妊娠时间、流产和活产。

共有1191位女性有孕前清25-羟基维生素D浓度数据,555位(47%)25-羟基维生素D≥75nmol/L(有效浓度)、636(53%)位 25-羟基维生素D<75nmol/L(浓度不足)。与25-羟基维生素D浓度低于75nmol/L的女性相比,25-羟基维生素D≥75nmol/L的女性更有可能获得临床妊娠(校正风险比[RR] 1.10[1.01-1.20])和活产(1.15[95% CI 1.02-1.29])。在获得临床妊娠的女性中,孕前25-羟基维生素D浓度充足,而非孕8周时的浓度,与流产风险降低相关(孕前RR/25nmol/L 0.88[95% CI 0.77-0.99];孕8周 0.98[0.95-1.01])。孕前25-羟基维生素D浓度充足与否,对女性繁殖能力的影响未见差异(校正FOR 1.13[95% CI 0.95-1.34])。

有效的孕期25-羟基维生素D浓度(≥75nmol/L)可增加妊娠和活产的可能性。孕期补充维生素D,而非孕早期,可降低流产风险。

原始出处:

Sunni L Mumford, et al. Association of preconception serum 25-hydroxyvitamin D concentrations with livebirth and pregnancy loss: a prospective cohort study. The Lancet Diabetndocinology.May 20,2018.https://doi.org/10.1016/S2213-8587(18)30153-0

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    2018-12-25 howi
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    2019-02-12 楚秀娟
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    2018-06-03 zhouqu_8
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    2018-06-01 虈亣靌

    优质资源.共同学习

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