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Acta Paediatr:婴儿期BMI z-分数与三岁儿童代谢与身体指标的相关性

2024-06-23 liangying MedSci原创 发表于上海

婴儿期BMI z-分数与三岁儿童代谢及身体指标之间的显著关联。

随着全球儿童肥胖率的持续上升,其对公共卫生的负担日益加重。众多研究显示,婴儿期的过快生长与儿童晚期及成年早期心血管疾病、代谢不良和2型糖尿病的风险增加有关。然而,针对10岁以下儿童的代谢综合征尚未有明确定义,且这一年龄段儿童的不良代谢效应日益增多,肥胖儿童的风险尤为显著。此研究旨在调查0至2岁儿童的BMI z-分数与三岁时的BMI z-分数、体脂百分比及代谢风险因素之间的关联,以便揭示早期生长模式与后期健康结果之间的潜在联系,并为早期干预提供依据。

本研究为对丹麦生活方式在妊娠和后代(LiP Offspring)队列的二次分析。原始的LiP研究是在2007年至2010年间在丹麦的两家大学医院进行的随机对照试验,针对的是孕前BMI为30-45 kg/m²的18至40岁孕妇。参与者在孕早期(10-14周)被随机分配到接受饮食指导和体育活动的生活方式干预组或对照组。本次随访研究选择了正常体重孕前BMI为18.5-24.9 kg/m²的母亲及其子女,形成了外部参照组。所有数据收集包括体测量(如臀围、腹围和皮褶厚度)及代谢结果(如脂肪质量、血压、胰岛素抵抗等)。

研究共分析了246对母婴对,包括来自干预组、对照组及外部参照组的数据。结果显示,从出生到两岁的BMI z-分数与三岁时的BMI z-分数及体脂百分比显著正相关。然而,五周大时的BMI z-分数与代谢风险因素组没有显著关联,这可能与符合代谢风险定义的儿童数量较少有关。此外,五周大的BMI z-分数与其他与代谢风险相关的因素(如体脂质量和腹围)有关联。值得注意的是,儿童的BMI z-分数与三岁时的多项身体和代谢指标均呈正相关,显示出其作为早期生长和健康风险指标的潜力。

5 周至 2 岁 BMI z 评分以及 3 岁人体测量和代谢结果的校正分析

本研究揭示了婴儿期BMI z-分数与三岁儿童代谢及身体指标之间的显著关联,为早期识别和干预儿童健康问题提供了科学依据。这些发现强调了监测和评估婴儿和幼儿BMI的重要性,可能有助于预防儿童期及成年早期的代谢疾病和肥胖。未来研究需要进一步探讨BMI z-分数的临界值,以确定未来健康风险最高的儿童群体,从而为临床实践和公共卫生政策提供指导。

原始出处:

Body mass index z-scores in the first 2 years of life were associated with adverse metabolic and anthropometric outcomes at 3 years of age. Acta Paediatr. 2024 May;113(5):1068-1075. doi: 10.1111/apa.17122.

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    2024-06-23 1209e435m98(暂无昵称) 来自浙江省

    学习了,谢谢分享

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2211293, encodeId=99442211293cd, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jun 23 21:21:06 CST 2024, time=2024-06-23, status=1, ipAttribution=浙江省), GetPortalCommentsPageByObjectIdResponse(id=2211280, encodeId=5da222112808b, content=前沿知识实用学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20c53431821, createdName=13013f32m56暂无昵称, createdTime=Sun Jun 23 16:34:25 CST 2024, time=2024-06-23, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2211303, encodeId=112b2211303b1, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sun Jun 23 23:12:47 CST 2024, time=2024-06-23, status=1, ipAttribution=山西省), GetPortalCommentsPageByObjectIdResponse(id=2211240, encodeId=f0aa221124041, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Sun Jun 23 14:00:51 CST 2024, time=2024-06-23, status=1, ipAttribution=浙江省), GetPortalCommentsPageByObjectIdResponse(id=2210644, encodeId=849e221064451, content=<a href='/topic/show?id=59d628408fa' target=_blank style='color:#2F92EE;'>#儿童肥胖#</a> <a href='/topic/show?id=4c5525496ad' target=_blank style='color:#2F92EE;'>#代谢风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25496, encryptionId=4c5525496ad, topicName=代谢风险), TopicDto(id=28408, encryptionId=59d628408fa, topicName=儿童肥胖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cade5395722, createdName=梅斯管理员, createdTime=Wed Jun 19 13:22:45 CST 2024, time=2024-06-19, status=1, ipAttribution=上海)]
    2024-06-23 13013f32m56暂无昵称 来自河北省

    前沿知识实用学习学习

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2211293, encodeId=99442211293cd, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jun 23 21:21:06 CST 2024, time=2024-06-23, status=1, ipAttribution=浙江省), GetPortalCommentsPageByObjectIdResponse(id=2211280, encodeId=5da222112808b, content=前沿知识实用学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20c53431821, createdName=13013f32m56暂无昵称, createdTime=Sun Jun 23 16:34:25 CST 2024, time=2024-06-23, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2211303, encodeId=112b2211303b1, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sun Jun 23 23:12:47 CST 2024, time=2024-06-23, status=1, ipAttribution=山西省), GetPortalCommentsPageByObjectIdResponse(id=2211240, encodeId=f0aa221124041, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Sun Jun 23 14:00:51 CST 2024, time=2024-06-23, status=1, ipAttribution=浙江省), GetPortalCommentsPageByObjectIdResponse(id=2210644, encodeId=849e221064451, content=<a href='/topic/show?id=59d628408fa' target=_blank style='color:#2F92EE;'>#儿童肥胖#</a> <a href='/topic/show?id=4c5525496ad' target=_blank style='color:#2F92EE;'>#代谢风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25496, encryptionId=4c5525496ad, topicName=代谢风险), TopicDto(id=28408, encryptionId=59d628408fa, topicName=儿童肥胖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cade5395722, createdName=梅斯管理员, createdTime=Wed Jun 19 13:22:45 CST 2024, time=2024-06-19, status=1, ipAttribution=上海)]
    2024-06-23 医鸣惊人 来自山西省

    认真学习了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2211293, encodeId=99442211293cd, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jun 23 21:21:06 CST 2024, time=2024-06-23, status=1, ipAttribution=浙江省), GetPortalCommentsPageByObjectIdResponse(id=2211280, encodeId=5da222112808b, content=前沿知识实用学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20c53431821, createdName=13013f32m56暂无昵称, createdTime=Sun Jun 23 16:34:25 CST 2024, time=2024-06-23, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2211303, encodeId=112b2211303b1, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sun Jun 23 23:12:47 CST 2024, time=2024-06-23, status=1, ipAttribution=山西省), GetPortalCommentsPageByObjectIdResponse(id=2211240, encodeId=f0aa221124041, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Sun Jun 23 14:00:51 CST 2024, time=2024-06-23, status=1, ipAttribution=浙江省), GetPortalCommentsPageByObjectIdResponse(id=2210644, encodeId=849e221064451, content=<a href='/topic/show?id=59d628408fa' target=_blank style='color:#2F92EE;'>#儿童肥胖#</a> <a href='/topic/show?id=4c5525496ad' target=_blank style='color:#2F92EE;'>#代谢风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25496, encryptionId=4c5525496ad, topicName=代谢风险), TopicDto(id=28408, encryptionId=59d628408fa, topicName=儿童肥胖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cade5395722, createdName=梅斯管理员, createdTime=Wed Jun 19 13:22:45 CST 2024, time=2024-06-19, status=1, ipAttribution=上海)]
    2024-06-23 yangchou 来自浙江省

    好文章,谢谢分享。

    0

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母亲的孕前超重和肥胖、巨大儿、儿童在6月龄至2岁的BMI增长速度加快等因素与儿童代谢健康型肥胖相关。

开学“健康准备”中,而医生最关注这些问题——

2023年秋季入园入学健康评估,正“如火如荼”进行中。与此同时,儿科医生们也发现了小朋友的一些健康问题,睡眠时长、视力异常、矮小肥胖等,甚至还有一些小朋友没有完善地接种疫苗。

Nature子刊:发现一种特殊的基因突变,与儿童肥胖相关

虽然在分离细胞中的这些实验支持他们的模型,研究团队指出,该研究尚未确认患者脑中的 ASIP 表达和MC4R抑制。要确定地将基因重排与人类的肥胖相关联,还需要进一步在人类和动物模型中进行研究。

JAMA子刊:全新孕妇代谢亚型可有效预测后代肥胖风险!

在这个队列研究中,无监督聚类分析揭示了孕妇的不同代谢亚群。

JAMA子刊:孕期促炎饮食及心理压力对儿童肥胖和生长轨迹的影响

同时评估妇女的产前饮食和心理社会压力作为预防儿童过度肥胖的干预目标可能是有用的。

JAMA子刊:儿童肥胖呈逐年上涨趋势,零食和饮料广告的泛滥或是诱因之一!

食品营销与儿童和青少年摄入、选择、偏好和购买请求的增加有关。实施限制儿童接触的政策有望有益于儿童健康。

WJP:肥胖儿童的昼夜节律健康状况

研究利用GCS确定学龄儿童生理健康与肥胖之间的潜在关联,还评价了GCS中昼夜节律特征与肥胖的相关性。

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