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Am J Gastroenterol:2030年食管腺癌疾病负担风险预测

2017-06-10 zhangfan MedSci原创

在未来发达国家食管腺癌负担急剧上升,并在未来几年或将超过食管鳞癌发病率,尤其是男性人群是食管腺癌高风险人群。尽管基于趋势的预测和亚型分类存在一定的不确定性,但目前食管癌的流行病学正发生转变,与未来的癌症控制和临床治疗密切相关

近几十年来,发达国家食管腺癌发病率迅速上升,引起了公众的关注。近日研究人员利用相关发病资料对未来组织学亚型食管腺癌负担进行预测。

研究人员从12个国家收集了食管腺癌诊断、性别、组织学和年龄组等发病率数据。通过拟合和推算年龄-周期-队列模型预测2030年新病例数和发病率并且研究了人口与风险变化对未来病例的影响。

研究表明,2005-2030年间总的新发食管腺癌病例数快速增长,但食管鳞状细胞癌的发病率预计将继续下降。预计到2030年,荷兰和英国每100名男性中有1人将患食管腺癌。

研究者认为,在未来发达国家食管腺癌负担急剧上升,并在未来几年或将超过食管鳞癌发病率,尤其是男性人群是食管腺癌高风险人群。尽管基于趋势的预测和亚型分类存在一定的不确定性,但目前食管癌的流行病学正发生转变,与未来的癌症控制和临床治疗密切相关。

原始出处:


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    2018-04-13 许安
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    2017-06-16 为你把脉

    v不v不会古古怪怪一样

    0

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    2017-06-11 zhouqu_8
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    2017-06-11 flysky120

    癌症彻底治疗什么时候?

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目的:上纵隔及腹腔动脉新辅助治疗和切除后发现淋巴结转移不改变食管癌的TNM分类。这些遥远的淋巴结转移对生存的影响仍不清楚。因此研究者进行了研究,探究食管或胃食管交界(GEJ) 腺癌患者新辅助治疗后食管切除术治疗患者,淋巴结转移位置的预后意义。方法:纳入2003-3至2013-9的479例食道远端或GEJ腺癌患者,进行了新辅助化疗后经胸食管切除术,根据切除标本淋巴结阳性定位,分析生存期。结果:253

Gut:经内镜发现的食管腺癌患者预后更好

近期发表在Gut的一项队列研究结果表明,对于发展为食管腺癌(EAC)的Barrett’s食管(BE)患者,如果是通过内镜监测发现癌症,那么患者的预后会更好。休斯敦贝勒医学院的Hashem B. El-Serag博士对2003-2009年确诊的29536例BE患者进行了研究。若有影响整体生存的并发症则排除在外。在平均5年的随访期间,424例发展为EAC,其中49.3%的患者通过内镜监测发现癌症;非B

Lancet Oncol:Barrett食管发展为食管腺癌,与哪些基因有关?

高收入国家的食管腺癌发病率节节攀升,虽然Barrett食管是其癌前病变,但是从Barrett食管发展为食管腺癌仍是极少数,不过对于这种恶化发展的预测仍缺乏有效指标。因此有研究者进行了全基因组荟萃分析,识别Barrett食管发展为食管腺癌的遗传变异风险。 研究纳入了来自欧洲、北美和澳大利亚的四项基于高密度单核苷酸多态性(SNP)阵列测序的全基因组关联研究,共6167例Barrett食管患者、4

盘点:近期食管腺癌相关研究进展

【1】Lancet Oncol:Barrett食管发展为食管腺癌,与哪些基因有关?高收入国家的食管腺癌发病率节节攀升,虽然Barrett食管是其癌前病变,但是从Barrett食管发展为食管腺癌仍是极少数,不过对于这种恶化发展的预测仍缺乏有效指标。因此有研究者进行了全基因组荟萃分析,识别Barrett食管发展为食管腺癌的遗传变异风险。研究纳入了来自欧洲、北美和澳大利亚的四项基于高密度单核苷酸多态

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