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JAHA:中国成年人中抑郁症与缺血性心脏病的风险增加相关

2016-12-22 haofan MedSci原创

由此可见,过去一年里,中国成年人中抑郁症与缺血性心脏病的风险增加相关,并且独立于其他主要心血管危险因素。

越来越多的证据表明,抑郁症与缺血性心脏病风险增加相关。近日,心血管病领域权威杂志JAHA上发表了一篇研究文章,旨在使用来自中国Kadoorie生物研究的数据来评估中国成人中抑郁症与缺血性心脏病风险之间的关系。

研究人员随访了超过50万名年龄在30岁至79岁之间的成年人,从基础随访开始(2004-2008年)直到2013年12月31日。在研究之初,用改进的短版的复合性国际诊断访谈表本中国版来评估去年抑郁症的情况。发生缺血性心脏病的病例通过联接相关的医疗数据库来确定,并被定义为患有疾病和有关健康问题的国际统计分类第十次修订本中代码为I20- I25的疾病。研究人员采用Cox比例风险回归模型来估计对社会人口统计学变量和确定的心血管危险因素进行调整后抑郁症与缺血性心脏病之间相关性的风险比和95%可信区间。

在3,423,542人次每年的随访中,有24,705例发生缺血性心脏病。相比于无抑郁症患者,研究者发现抑郁症患者中缺血性心脏病发病率更高(8.76 vs. 7.21人每1000人每年),并且多变量调整后的危险比为1.32(95%可信区间为1.15-1.53)。地理位置也会影响这种相关性(P交互作用=0.005),并在城市居民中可观察到成正相关(风险比为1.72;95%可信区间为1.39-2.14),但在农村居民中无这种相关性(1.13;0.93-1.37)。与无抑郁症状的参与者相比,对于那些只有抑郁症状的患者其缺血性心脏病的风险比(95%可信区间)为1.13(1.04-1.23),而抑郁症患者为1.33(1.15-1.53)

由此可见,过去一年里,中国成年人中抑郁症与缺血性心脏病的风险增加相关,并且独立于其他主要心血管危险因素。

原始出处:

Na Liu, et al. Association of Major Depression With Risk of Ischemic Heart Disease in a Mega‐Cohort of Chinese Adults: The China Kadoorie Biobank Study. JAHA.December 21, 2016. 


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    2016-12-26 三生有幸9135

    双心疾病应该共同预防。

    0

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    2016-12-24 zhaohui6731
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    2016-12-23 三生有幸9135

    心身互相影响!

    0

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    2016-12-23 医6666

    每天来学习一次!

    0

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    2016-12-23 SAd

    这个确实是这样

    0

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