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鞍区中枢神经细胞瘤一例

2017-12-14 佚名 中华神经医学杂志

患者男性,56岁

【一般资料】

患者男性,56岁

【主诉】

因"外伤后行头部CT发现鞍区占位"于2015年9月收治入襄阳市中心医院神经外科。

【体格检查】

左眼视力0.2,右眼1.0,双颞侧偏盲,无其他神经系统阳性体征。

【辅助检查】

头部MRI示鞍内以及鞍上池内占位,T1像稍低信号、T2像等信号,增强时均匀强化,大小约3cm×2cm,病变突入前颅窝底(图1A,图1B,图1C)。内分泌检查:上午8:00皮质醇轻度降低(0.068μg/mL)(正常范围0.087~0.224μg/mL),余垂体前叶激素正常。

【初步诊断

结合患者临床表现以及影像学特点考虑为垂体腺瘤。

【治疗】

手术在全麻下行左侧翼点入路鞍区占位切除术,术中见肿瘤紫红色,起源于鞍膈,肿瘤质地不硬、血供不丰富,分块全切肿瘤。术后左眼视力改善,恢复至0.6。激素复查正常。患者治愈后出院,无手术并发症。术后病理检查:镜下见小至中等大小一致肿瘤细胞,紧密排列,部分细胞质空亮、圆形细胞核、"盐和胡椒粉"状染色质(斑点状染色质),镜下亦可见树枝状排列的薄壁毛细血管(图2A、图2B)。免疫组化染色示:突触素(SYN)、嗜铬素A(CGA)、神经元特异性烯醇化酶(NSE)阳性,黄体生成素(LH)、卵泡刺激素(FSH)、生长激素(GH)、泌乳素(PRL)、促肾上腺皮质激素(ACTH)、促甲状腺激素(TSH)、胶质纤维酸性蛋白(GFAP)、S-100蛋白、神经巢蛋白、上皮膜抗原(EMA)阴性,Ki67约0~1%。最后病理诊断:EVN,WHOⅡ级。




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