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CLIN CANCER RES:三阴性乳腺癌铂基新辅助化疗期间肿瘤BRCA1反向突变增加且与治疗抵抗有关

2017-07-09 MedSci MedSci原创

对BRCA1或BRCA2(BRCA1/2)突变携带者,通过二次突变恢复肿瘤BRCA1/2功能被认为是铂类以及PARP抑制剂治疗抵抗的机制之一。CLIN CANCER RES近期发表了一篇文章,研究对新辅助铂基化疗反应差的新发BRCA1/2突变乳腺癌的治疗抵抗机制。

对BRCA1或BRCA2(BRCA1/2)突变携带者,通过二次突变恢复肿瘤BRCA1/2功能被认为是铂类以及PARP抑制剂治疗抵抗的机制之一。CLIN CANCER RES近期发表了一篇文章,研究对新辅助铂基化疗反应差的新发BRCA1/2突变乳腺癌的治疗抵抗机制。

PrECOG 0105是一项研究吉西他滨、卡铂以及iniparib新辅助治疗Ⅰ-ⅢA期三阴性乳腺癌或BRCA1/2突变相关乳腺癌的Ⅱ期临床试验(n=80)。所有患者均接受BRCA1/2基因分型。对于新辅助治疗后依然存在中量或大量残余病灶的突变携带者,针对切除后的残余乳腺癌组织再次检测BRCA1/2状态。19例患者存在BRCA1/2突变,4例在接受手术时存在中量残余病灶。3例患者的残余病灶进行了BRCA1/2测序,这些患者分别存在BRCA1 1479delAG,3347insGA以及W1712X突变。第一例患者残余肿瘤组织中检测到新的BRCA1突变。这导致14个氨基酸缺失以及BRCA1读码框恢复。4个月后针对局部复发的肿瘤活检发现相同的反向突变,该患者死于后续的远处转移乳腺癌。

文章最后提到,新发三阴性乳腺癌患者接受18周铂基新辅助治疗后出现BRCA1/2反向突变。这与治疗反应不良、早期复发以及死亡有关。

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content=谢谢分享受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ae02063908, createdName=152****8376, createdTime=Sun Jul 09 10:25:46 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
  5. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3684, encryptionId=63cc368459, topicName=BRCA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Tue Jul 11 00:11:00 CST 2017, time=2017-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220757, encodeId=ea53220e57dd, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Mon Jul 10 16:48:01 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220573, encodeId=60602205e3e4, content=好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Jul 10 07:12:05 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220281, encodeId=a5cd22028164, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Jul 09 10:49:23 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220276, encodeId=23c72202e6e0, content=谢谢分享受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ae02063908, createdName=152****8376, createdTime=Sun Jul 09 10:25:46 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2017-07-11 xlysu
  6. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Jul 10 07:12:05 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220281, encodeId=a5cd22028164, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Jul 09 10:49:23 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220276, encodeId=23c72202e6e0, content=谢谢分享受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ae02063908, createdName=152****8376, createdTime=Sun Jul 09 10:25:46 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2017-07-11 智智灵药
  7. 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content=谢谢分享受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ae02063908, createdName=152****8376, createdTime=Sun Jul 09 10:25:46 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2017-07-10 luominglian113

    学习了谢谢分享

    0

  8. 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content=谢谢分享受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ae02063908, createdName=152****8376, createdTime=Sun Jul 09 10:25:46 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2017-07-10 ylzr123

    好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。

    0

  9. 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content=谢谢分享受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ae02063908, createdName=152****8376, createdTime=Sun Jul 09 10:25:46 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2017-07-09 李东泽

    很好,不错,以后会多学习

    0

  10. 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content=谢谢分享受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ae02063908, createdName=152****8376, createdTime=Sun Jul 09 10:25:46 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2017-07-09 152****8376

    谢谢分享受益匪浅

    0

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三阴性乳腺癌(TNBC)是指癌组织免疫组织化学检查结果为雌激素受体(ER)、孕激素受体(PR)和原癌基因Her-2均为阴性的乳腺癌。临床表现为一种侵袭性病程,其远处转移风险较高,内脏转移机会较骨转移高,脑转移几率也较高,预后较其他类型差。

Sci Rep:催乳素或成治疗三阴性乳腺癌的新武器

最近来自加拿大麦吉尔大学健康中心研究所的一项研究表明对乳腺癌病人进行催乳素受体筛查有助于改善部分病人的预后,或可帮助病人避免接受不必要的和侵入性治疗。在对580名三阴性乳腺癌病人的数据进行分析之后,研究人员发现表达催乳素受体的病人生存时间更长,催乳素能够降低癌细胞的侵袭行为。相关研究结果发表在国际学术期刊Scientific Reports上。三阴性乳腺癌是一类雌激素受体,黄体酮受体和HER2都呈

Cancer Res:三阴性乳腺癌转移必需蛋白BRD4被发现

在一项新的研究中,研究人员鉴定出一种新的通路和一种蛋白(BRD4)---是乳腺癌扩散所必需的。这些发现为抑制乳腺癌转移提供一种新的靶标。相关研究结果发表在2016年11月那期Cancer Research期刊上,论文标题为“BRD4 Regulates Breast Cancer Dissemination through Jagged1/Notch1 Signaling”。三阴性乳腺癌被认为是最

Cancer Lett:昆明动物所等发现冬凌草甲素衍生物可有效治疗三阴性乳腺癌

乳腺癌是发生在乳腺上皮组织的恶性肿瘤,它的发病率在世界范围内处于女性恶性肿瘤之首,并且呈现年轻化趋势。其中,最为恶性的三阴性乳腺癌(TNBC)由于缺乏特异的治疗靶点和靶向治疗方法,成为乳腺癌的研究难点和热点。目前TNBC的常用化疗药物虽然见效快,但病人痛苦且容易复发,从药用植物中筛选或进一步合成抗肿瘤药物则可能可以弥补这些缺点和不足。冬凌草(Rabdosia rubescens)属唇形科香茶菜属碎

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