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Neurology:年轻脑缺血患者,发生心血管事件的风险较高

2016-06-29 phylis 译 MedSci原创

目的:为了研究年轻卒中患者复发性心脏、动脉和静脉事件的长期风险,以及不同病因亚组间,这些风险的不同。方法:研究人群包括来自赫尔辛基卒中登记记录(HYSR)的15-49岁缺血性脑卒中(1994-2007年)患者970例。研究者从芬兰护理登记和统计记录中获得直到2012年的随访数据。应用生命表分析累积15年的风险,Cox回归分析得出基于HR的相对风险(RR)和相应的置信区间(CI)。结果:在中位数为1

目的:为了研究年轻卒中患者复发性心脏、动脉和静脉事件的长期风险,以及不同病因亚组间,这些风险的不同。

方法:研究人群包括来自赫尔辛基卒中登记记录(HYSR)的15-49岁缺血性脑卒中(1994-2007年)患者970例。研究者从芬兰护理登记和统计记录中获得直到2012年的随访数据。应用生命表分析累积15年的风险,Cox回归分析得出基于HR的相对风险(RR)和相应的置信区间(CI)。

结果:在中位数为10.1年(范围0.1-18.0年)的随访中,有283(29.2%)患者发生心血管事件。静脉事件累计15年的风险为3.9%。复合血管事件15年累积发病率为34(95% CI 30.1-38.2)每1000人-年。校正年龄和性别,与其他心血管事件相比,心源性脑栓塞的高风险造成脑卒中HR最高(3.7;95% CI 2.6-5.4),而与其他病因不明的卒中患者相比,大动脉粥样硬化组发生再发卒中的HR最高(2.7;95% CI 1.6-4.6)。

结论:青年缺血性脑卒中后未来发生心血管事件的风险多年后仍较高,特别是心源性栓塞或大动脉粥样硬化高风险人群引起的卒中。

原始出处:

Aarnio K, Siegerink B, et al. Cardiovascular events after ischemic stroke in young adults: A prospective follow-up study. Neurology. 2016 May 17


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    2016-10-11 ylzr123

    拜读了,受益匪浅,点个赞!

    0

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    2016-07-04 保守主义

    有所启发

    0

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    2017-04-16 yinhl1978
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    2016-06-30 乐奕11

    学了一些

    0

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