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JAMA Pediatr:影响早产儿认知能力的围产期因素

2018-03-05 zhangfan MedSci原创

研究发现因支气管肺发育不良,使用肺表面活性物质以及激素的早产新生儿其儿童期认知能力显著降低。早产对认知的负面影响在近20多年来一直都是产科及新生儿科的巨大难题,如何降低早产儿支气管肺发育不良率可能是改善这一问题的关键

尽管围产期护理取得了明显进步,但极端早产或非常早产新生儿(EP/VP)认知缺陷的高风险仍然较高。近日研究人员考察了影响EP/VP新生儿认知能力的围产期和人口因素。

研究对截止2017年3月的相关文献进行检索,月龄小于32周的EP/VP儿童参与,对儿童5岁以后的认知能力进行考察,围产期和人口因素因素包括胎龄、出生体重、出生年份、年龄、性别、民族、社会经济状况、胎龄小、脑室出血、脑白质软化、支气管肺发育不良(BPD)、坏死性小肠结肠炎、脓毒症和产后使用皮质类固醇。

71个研究,7752名EP/VP以及5155名对照儿童参与研究,早产儿平均月龄28.5周,认知测试年龄5-20.1岁,男女比例各半。与对照组相比,早产儿认知得分平均低0.86SD,但结果异质性显著(I2=74.13; P<0.001)。多因素分析显示,BPD可解释65%的认知缺陷,队列中BPD发生率每增加1%,平均智商成绩下降0.01SD。

研究发现因支气管肺发育不良,使用肺表面活性物质以及激素的早产新生儿其儿童期认知能力显著降低。早产对认知的负面影响在近20多年来一直都是产科及新生儿科的巨大难题,如何降低早产儿支气管肺发育不良率可能是改善这一问题的关键。

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    2019-02-06 feather89
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    2018-05-10 jyzxjiangqin

    影响早产儿认知能力的围产期因素.

    0

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    2018-04-16 jyzxjiangqin

    影响早产儿认知能力.

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1727123, encodeId=eb241e2712345, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Feb 06 07:23:00 CST 2019, time=2019-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313696, encodeId=5c0b31369647, content=影响早产儿认知能力的围产期因素., beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Thu May 10 06:25:11 CST 2018, time=2018-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=306277, encodeId=79593062e789, content=影响早产儿认知能力., beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Mon Apr 16 07:34:03 CST 2018, time=2018-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638469, encodeId=f999163846973, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed Sep 12 09:23:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294845, encodeId=815d29484541, content=不错耶.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b2c1627329, createdName=owlhealth, createdTime=Sat Mar 10 10:53:18 CST 2018, time=2018-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294233, encodeId=3d402942332f, content=很好的学习材料.对临床和科研都有很大帮助作用.水滴石穿.不断积累., beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Mar 08 18:24:08 CST 2018, time=2018-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293784, encodeId=9a4a293e8436, content=影响早产儿认知能力的围产期因素., beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Mar 07 07:36:03 CST 2018, time=2018-03-07, status=1, ipAttribution=)]
    2018-03-10 owlhealth

    不错耶.学习了

    0

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    2018-03-08 虈亣靌

    很好的学习材料.对临床和科研都有很大帮助作用.水滴石穿.不断积累.

    0

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    2018-03-07 jyzxjiangqin

    影响早产儿认知能力的围产期因素.

    0

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