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Int J Nanomedicine:外泌体通过上调血红素加氧酶-1促进雄激素依赖性前列腺癌细胞向不依赖雄激素转变

2021-02-03 AlexYang MedSci原创

去势抵抗性前列腺癌(CRPC)仍不能治愈,尽管CRPC的机制已有广泛研究。研究表明,肿瘤微环境中的外泌体有利于前列腺癌的发展和进展。然而,外泌体在CRPC进展过程中的作用尚未确定。

去势抵抗性前列腺癌(CRPC)仍不能治愈,尽管CRPC的机制已有广泛研究。研究表明,肿瘤微环境中的外泌体有利于前列腺癌的发展和进展。然而,外泌体在CRPC进展过程中的作用尚未确定

研究人员使用共培养和外泌体处理试验,并结合体外和体内试验确定了外泌体在雄激素依赖性前列腺癌(ADPC)细胞转化为雄激素非依赖性细胞中的功能。研究结果表明,ADPC细胞获得对雄激素阻断的耐受性是由于外泌体介导的细胞间交流。体内和体外试验表明,AIPC细胞来源的外泌体促进了ADPC细胞转化为雄激素非依赖细胞。微阵列分析显示,用AIPC细胞来源的外泌体处理后,ADPC细胞中的HMOX1上调。进一步的结果表明,HMOX1在人类AIPC样本中过表达,并在雄激素阻断中保护ADPC细胞。

PC-3来源外泌体能够促进LNCAP细胞的去势抗性

最后,研究人员指出,外泌体通过激活HMOX1,促进前列腺癌细胞转化为雄激素非依赖的生长阶段,从而有助于CRPC的进展

原始出处:

Yiming Zhang, Binshen Chen , Naijin Xu et al. Exosomes Promote the Transition of Androgen-Dependent Prostate Cancer Cells into Androgen-Independent Manner Through Up-Regulating the Heme Oxygenase-1. Int J Nanomedicine. Jan 2021

 

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    2021-04-20 kalseyzl
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    2021-11-07 jeanqiuqiu
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    2021-02-05 yxch36
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    2021-02-04 carrotlyl

    学习了

    0

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    2021-02-03 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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