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Cell Host & Microbe:你以为肠道细菌的数目决定它们功能是否强大么?错

2015-11-13 QQduhq 译 MedSci原创

无数研究结果表明,数以万亿计的肠道微生物对我们的健康至关重要。且研究人员发现,某些数量较少的肠道微生物也对人体健康发挥着不可替代的功能。

无数研究结果表明,数以万亿计的肠道微生物对我们的健康至关重要。且研究人员发现,某些数量较少的肠道微生物也对人体健康发挥着不可替代的功能。


这个重要的发现来自于发表在Cell Host & Microbe上的俄勒冈大学的研究项目。 研究人员认为,他们的发现有利于医生通过调节肠道微生物群预防和治疗,甚至预测疾病。 

研究人员利用斑马鱼开展研究。他们对健康斑马鱼的肠道细菌进行了探究,并将这些肠道细菌移植入肠道无细菌的斑马鱼中,并探究这些斑马鱼肠道细菌种类的丰富度及中性粒细胞尤其是白细胞的数目变化。

他们发现,某些类型的细菌似乎对机体健康有更大的影响。例如,弧菌属可快速引起机体出现炎症反应,而希瓦氏菌属几乎不会引起机体出现任何炎症反应。 

当研究人员把两种类型的细菌移植入不含肠道细菌的斑马鱼中,且使弧菌属所占比例为90%,希瓦氏菌属所占比例为10%。他们发现,斑马鱼是否出现炎症反应则由数量较少的菌属决定。

Annah S. Rolig博士认为,到目前为止,研究人员只能够获得细菌的数目比例。各种微生物群数量分布就像一个饼状图。生物学家认为,这些细菌发回的作用相似或相同。

在研究疾病与肠道细菌的关系时,科学家们认为,数目较丰富的细菌物种对于民众患肥胖、糖尿病和炎性肠道疾病如克罗恩病等发挥了重要作用。但是他们在某种程度上忽视了那些数目较少的细菌所发挥的功能。

Rolig博士认为,细菌功能并不由细菌数目决定,他们还需要进行更多的研究,并对人们进行试验,以探究实验结果的有效性和准确性。

原始出处:

Good health relies on some less abundant gut microbes,MNT,13,Nov,2015

Individual Members of the Microbiota Disproportionately Modulate Host Innate Immune Responses, Annah S. Rolig et al., Cell Host & Microbe, 11 Nov, 2015

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    2015-12-11 智智灵药
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    2015-12-29 xyfg98

    0

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    2016-01-06 xjy02
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