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J Clin Endocrinol Metab:术后甲状旁腺功能减退患者:靠激素治疗能改善生活质量?

2018-02-05 吴星 环球医学

2018年1月,发表在《J Clin Endocrinol Metab》的一项由意大利科学家进行的前瞻性开放标签研究,考察了甲状旁腺激素(PTH)(1-34)治疗术后甲状旁腺功能减退的有效性和安全性并调查了这些患者的生活质量(QOL)。

2018年1月,发表在《J Clin Endocrinol Metab》的一项由意大利科学家进行的前瞻性开放标签研究,考察了甲状旁腺激素(PTH)(1-34)治疗术后甲状旁腺功能减退的有效性和安全性并调查了这些患者的生活质量(QOL)。

背景:每天使用(PTH)(1-34)可以降低难治甲状旁腺功能减退患者的钙和骨化三醇每日所需总体剂量,并储存正常血钙血。然而,大部分(PTH)(1-34)试验基于各种病因的甲状旁腺功能减退的较小队列,且并未调查QOL。

目的:在一个术后甲状旁腺功能减退成人受试者同质队列中,考察24个月(PTH)(1-34)治疗的影响,并评价QOL的变化。

设计:前瞻性开放标签研究。

地点:意大利多中心研究。

受试者:42个。

干预:每天2次皮下注射(PTH)(1-34)20 μg。

主要结局测量指标:钙和维生素D补充需求、血清钙、磷酸盐和尿钙排泄(3个月、6个月、12个月、18个月和24个月)。基线和6个月及24个月时,通过涵盖身体和精神健康8个领域的RAND 36项简表(SF-36)健康调查,评价QOL。

结果:基线至3个月,尽管钙和维生素D补充降低, 但平均血清浓度显着增加(7.6±0.6 vs 8.9±1.1 mg/dL,P<0.001),并维持稳定,直至研究结束时。基线至6个月,磷酸盐水平逐渐降低(4.3±1.1 vs 3.9±0.6 mg/dL,P<0.019),并保持稳定,直至24个月。SF-36调查数据显示所有8个领域的平均评分得到改善(P<0.001)。

结论:该研究证明了(PTH)(1-34)治疗成人手术后甲状旁腺功能减退的有效性和安全性。(PTH)(1-34)或可改善这类患者的精神和身体健康。

原始出处

Fatma Gossiel, Jessica R Scott, Margaret A Paggiosi, et al. The effect of teriparatide treatment on circulating periostin and its relationship to regulators of bone formation and BMD in postmenopausal women with osteoporosis. The Journal of Clinical Endocrinology & Metabolism, jc.2017-00283.

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    2018-09-21 一闲
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    2018-10-19 guojianrong
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    2018-02-05 huizi3382

    对临床治疗有很大帮助

    0

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Ann Thorac Surg:微创切除纵隔异位甲状旁腺可明显缩短患者住院时间

异位甲状旁腺需要行手术切除术时,大多通过颈部切口,但是1%~2%的患者将需要经胸骨或经胸扩切口手术。微创手术是最近出现的一种作为替代传统侵入性手术方式的新方法,然而其相关数据仍比较缺乏。针对这种情况,来自美国明尼苏达州罗切斯特市梅奥诊所普胸外科的Wigle博士等人进行了一项研究,研究结果在线发表于2013年8月20日的《胸外科年鉴》(AnnThoracSurg)杂志上。作者发现微创纵隔甲状旁腺切除

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