CLIN CHEM：分析蛋白质组学发现的标志物和验证肝素给药对心血管生物标志物分析的混淆效应

2018-10-30 MedSci MedSci原创

一些血浆蛋白被认为是多种心血管疾病的标志物，但在独立的患者队列中情况却并非如此。这可能与药物对血浆蛋白浓度的干扰有关。研究人员使用蛋白质组学来鉴定血浆蛋白，这些蛋白的浓度随肝素的使用而改变，因此在使用肝素的情况下，它们作为生物标志物的评估可能会出现混淆。研究人员使用了蛋白质组学的方法根据等压标签和nano-LC-MS / MS分析量化几百种蛋白质，个体血浆样本来自9例血管内超声随访12个月

一些血浆蛋白被认为是多种心血管疾病的标志物，但在独立的患者队列中情况却并非如此。这可能与药物对血浆蛋白浓度的干扰有关。研究人员使用蛋白质组学来鉴定血浆蛋白，这些蛋白的浓度随肝素的使用而改变，因此在使用肝素的情况下，它们作为生物标志物的评估可能会出现混淆。

研究人员使用了蛋白质组学的方法根据等压标签和nano-LC-MS / MS分析量化几百种蛋白质，个体血浆样本来自9例血管内超声随访12个月后急性心肌梗死患者肝素服用前和服用后2、15和60分钟后的样本。在500个单独的血浆样本中验证了此项发现，这些血浆样本来自于可疑的ST段抬高型心肌梗死(STEMI)患者，其中363人在入院前接受了肝素治疗。

结果显示，在本探索研究中，25 653例患者在肝素治疗后发现血浆蛋白浓度变化 (Bonferroni-corrected P值10 P < 7.66 5)。14个蛋白在肝素治疗患者中变化具有显著水平(P < 6.92十5)。在发现研究和验证研究中，肝素影响蛋白质中midkine、spondin 1、分泌frizzled-like蛋白1、脂蛋白脂肪酶和卵泡抑素都与STEMI有关。

结果表明，血液采样前给予肝素等药物可能与生物标志物发现相混淆，因而在此类研究中应慎重考虑。

原始出处：

Hans C. Beck, Lisette O. Jensen, Charlotte Gils, Proteomic Discovery and Validation of the Confounding Effect of Heparin Administration on the Analysis of Candidate Cardiovascular Biomarkers

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2019-08-25 jjjiang0211

#蛋白质组#

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2018-12-21 柳叶一刀

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2019-05-08 hukaixun

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2018-11-01 cmj8wellington

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2018-11-01 仁者大医

#生物标志#

71 0
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2018-11-01 zhu_jun9842

#生物标志#

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