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Am J Pathol:胆结石不开刀:预防和治疗胆结石的新方法

2017-03-16 佚名 来宝网

根据目前的预估,美国将有2千万到2.5千万人会发展成胆结石,几乎是成年人口的15%。虽然只有一部分会出现胆结石的症状,但是每年接受胆结石手术的人也达到了70万。近期,发表于《美国病理学》杂志中的研究报道记录了预防和治疗胆结石的新方法,通过激活肝脏和小肠中的组织,从而减少胆汁输出。

根据目前的预估,美国将有2千万到2.5千万人会发展成胆结石,几乎是成年人口的15%。虽然只有一部分会出现胆结石的症状,但是每年接受胆结石手术的人也达到了70万。近期,发表于《美国病理学》杂志中的研究报道记录了预防和治疗胆结石的新方法,通过激活肝脏和小肠中的组织,从而减少胆汁输出。

“随着生活水平的提高,高胆固醇食品摆上了人们的餐桌,因此胆结石成为了日渐增多的消化道疾病,我们的研究表明基本的雄烷接受器在维持体内胆固醇和甘油三酯平衡中所起的重要作用,这也代表了治疗胆结石的新方法。”

激活雄烷接受器可以改变胆囊和形成石头的肝胆汁的生化成分,除此之外,还可以提高胆固醇转化为胆汁酸的数量,提高胆汁酸的再吸收。总之,雄烷接受器对体内胆固醇、胆汁酸、和甘油三酯的平衡起着重要的作用。

胆结石通常是由于胆汁沉淀物中过多的胆固醇形成固体晶体,然后聚合和融合变成石头。在女性中更为常见,胆结石的形成归因于这个饮食、2型糖尿病代谢综合征、脂质代谢紊乱,和肥胖。尽管大多数患者胆结石保持无症状,但约五分之一会出现不舒服的症状,并伴有胰腺炎等并发症。目前,手术治疗是唯一的方法,但是侵入性的治疗不仅会带来副作用,风险大,而且成本也高。希望,此次新的研究能为胆结石的治疗提供全新的方案。

原始出处:

Shihai Cheng, Min Zou, et al.  Activation of Constitutive Androstane Receptor Prevents Cholesterol Gallstone Formation.  The American Journal of Pathology.Published online 7 March 2017.

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    2017-05-30 yb6560
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    2017-03-17 hhh678

    henhap

    0

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13:50:05 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180312, encodeId=b5e718031205, content=文章不错,值得分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Thu Mar 16 10:48:31 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180295, encodeId=0dcd18029561, content=文章不错,值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Mar 16 10:00:49 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180288, encodeId=fccd18028838, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib0kbzef1jKfxVxKKxoGdVMdMe54JuaABgJlOdkfVdUkxEReXZyZ0PMHhxlzMkiciaPAp2gJsoIbGKtA/0, createdBy=a2d51960177, createdName=komasun, createdTime=Thu Mar 16 09:30:20 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180283, encodeId=303218028350, content=很好,看看结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Thu Mar 16 08:47:58 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180281, encodeId=a57818028129, content=看看咯巴啦啦结局, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38b31934560, createdName=葫芦糊涂, createdTime=Thu Mar 16 08:45:41 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180280, encodeId=369c1802808c, content=学习了,希望有更多这样的咨询, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuMR3WZ1VnSfbWUadIWeyMyS20yXZARSoSoYng9V8Qjz3mK7SsCiazXVErDamlfgtiaWXjP1nv3I2tX/0, createdBy=94ef2037358, createdName=小太阳馒头, createdTime=Thu Mar 16 08:39:50 CST 2017, time=2017-03-16, status=1, ipAttribution=)]
    2017-03-16 kehan

    要是再详细些就好了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1903192, encodeId=2d1a190319249, content=<a href='/topic/show?id=e1b0583884b' target=_blank style='color:#2F92EE;'>#新方法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58388, encryptionId=e1b0583884b, topicName=新方法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c22f171, createdName=kord1982, createdTime=Wed Oct 11 06:16:00 CST 2017, time=2017-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1786169, encodeId=4cb61e861692e, content=<a href='/topic/show?id=569f13e9045' target=_blank style='color:#2F92EE;'>#Pathol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13790, encryptionId=569f13e9045, topicName=Pathol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Tue May 30 11:16:00 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180545, encodeId=1325180545e2, content=henhap, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Fri Mar 17 08:59:24 CST 2017, time=2017-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180337, encodeId=656718033eff, content=要是再详细些就好了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=910e1743423, createdName=kehan, createdTime=Thu Mar 16 13:50:05 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180312, encodeId=b5e718031205, content=文章不错,值得分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Thu Mar 16 10:48:31 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180295, encodeId=0dcd18029561, content=文章不错,值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Mar 16 10:00:49 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180288, encodeId=fccd18028838, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib0kbzef1jKfxVxKKxoGdVMdMe54JuaABgJlOdkfVdUkxEReXZyZ0PMHhxlzMkiciaPAp2gJsoIbGKtA/0, createdBy=a2d51960177, createdName=komasun, createdTime=Thu Mar 16 09:30:20 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180283, encodeId=303218028350, content=很好,看看结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Thu Mar 16 08:47:58 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180281, encodeId=a57818028129, content=看看咯巴啦啦结局, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38b31934560, createdName=葫芦糊涂, createdTime=Thu Mar 16 08:45:41 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180280, encodeId=369c1802808c, content=学习了,希望有更多这样的咨询, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuMR3WZ1VnSfbWUadIWeyMyS20yXZARSoSoYng9V8Qjz3mK7SsCiazXVErDamlfgtiaWXjP1nv3I2tX/0, createdBy=94ef2037358, createdName=小太阳馒头, createdTime=Thu Mar 16 08:39:50 CST 2017, time=2017-03-16, status=1, ipAttribution=)]
    2017-03-16 明天会更好!

    文章不错,值得分享!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1903192, encodeId=2d1a190319249, content=<a href='/topic/show?id=e1b0583884b' target=_blank style='color:#2F92EE;'>#新方法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58388, encryptionId=e1b0583884b, topicName=新方法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c22f171, createdName=kord1982, createdTime=Wed Oct 11 06:16:00 CST 2017, time=2017-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1786169, encodeId=4cb61e861692e, content=<a href='/topic/show?id=569f13e9045' target=_blank style='color:#2F92EE;'>#Pathol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13790, encryptionId=569f13e9045, topicName=Pathol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, 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13:50:05 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180312, encodeId=b5e718031205, content=文章不错,值得分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Thu Mar 16 10:48:31 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180295, encodeId=0dcd18029561, content=文章不错,值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Mar 16 10:00:49 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180288, encodeId=fccd18028838, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib0kbzef1jKfxVxKKxoGdVMdMe54JuaABgJlOdkfVdUkxEReXZyZ0PMHhxlzMkiciaPAp2gJsoIbGKtA/0, createdBy=a2d51960177, createdName=komasun, createdTime=Thu Mar 16 09:30:20 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180283, encodeId=303218028350, content=很好,看看结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Thu Mar 16 08:47:58 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180281, encodeId=a57818028129, content=看看咯巴啦啦结局, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38b31934560, createdName=葫芦糊涂, createdTime=Thu Mar 16 08:45:41 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180280, encodeId=369c1802808c, content=学习了,希望有更多这样的咨询, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuMR3WZ1VnSfbWUadIWeyMyS20yXZARSoSoYng9V8Qjz3mK7SsCiazXVErDamlfgtiaWXjP1nv3I2tX/0, createdBy=94ef2037358, createdName=小太阳馒头, createdTime=Thu Mar 16 08:39:50 CST 2017, time=2017-03-16, status=1, ipAttribution=)]
    2017-03-16 1e10c84am36(暂无匿称)

    文章不错,值得分享

    0

  7. 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13:50:05 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180312, encodeId=b5e718031205, content=文章不错,值得分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Thu Mar 16 10:48:31 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180295, encodeId=0dcd18029561, content=文章不错,值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Mar 16 10:00:49 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180288, encodeId=fccd18028838, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib0kbzef1jKfxVxKKxoGdVMdMe54JuaABgJlOdkfVdUkxEReXZyZ0PMHhxlzMkiciaPAp2gJsoIbGKtA/0, createdBy=a2d51960177, createdName=komasun, createdTime=Thu Mar 16 09:30:20 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180283, encodeId=303218028350, content=很好,看看结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Thu Mar 16 08:47:58 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180281, encodeId=a57818028129, content=看看咯巴啦啦结局, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38b31934560, createdName=葫芦糊涂, createdTime=Thu Mar 16 08:45:41 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180280, encodeId=369c1802808c, content=学习了,希望有更多这样的咨询, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuMR3WZ1VnSfbWUadIWeyMyS20yXZARSoSoYng9V8Qjz3mK7SsCiazXVErDamlfgtiaWXjP1nv3I2tX/0, createdBy=94ef2037358, createdName=小太阳馒头, createdTime=Thu Mar 16 08:39:50 CST 2017, time=2017-03-16, status=1, ipAttribution=)]
    2017-03-16 komasun

    学习了谢谢分享

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1903192, encodeId=2d1a190319249, content=<a href='/topic/show?id=e1b0583884b' target=_blank style='color:#2F92EE;'>#新方法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58388, encryptionId=e1b0583884b, topicName=新方法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c22f171, createdName=kord1982, createdTime=Wed Oct 11 06:16:00 CST 2017, time=2017-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1786169, encodeId=4cb61e861692e, content=<a href='/topic/show?id=569f13e9045' target=_blank style='color:#2F92EE;'>#Pathol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13790, encryptionId=569f13e9045, topicName=Pathol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, 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13:50:05 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180312, encodeId=b5e718031205, content=文章不错,值得分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Thu Mar 16 10:48:31 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180295, encodeId=0dcd18029561, content=文章不错,值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Mar 16 10:00:49 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180288, encodeId=fccd18028838, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib0kbzef1jKfxVxKKxoGdVMdMe54JuaABgJlOdkfVdUkxEReXZyZ0PMHhxlzMkiciaPAp2gJsoIbGKtA/0, createdBy=a2d51960177, createdName=komasun, createdTime=Thu Mar 16 09:30:20 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180283, encodeId=303218028350, content=很好,看看结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Thu Mar 16 08:47:58 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180281, encodeId=a57818028129, content=看看咯巴啦啦结局, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38b31934560, createdName=葫芦糊涂, createdTime=Thu Mar 16 08:45:41 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180280, encodeId=369c1802808c, content=学习了,希望有更多这样的咨询, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuMR3WZ1VnSfbWUadIWeyMyS20yXZARSoSoYng9V8Qjz3mK7SsCiazXVErDamlfgtiaWXjP1nv3I2tX/0, createdBy=94ef2037358, createdName=小太阳馒头, createdTime=Thu Mar 16 08:39:50 CST 2017, time=2017-03-16, status=1, ipAttribution=)]
    2017-03-16 o9887

    很好,看看结果

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1903192, encodeId=2d1a190319249, content=<a href='/topic/show?id=e1b0583884b' target=_blank style='color:#2F92EE;'>#新方法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58388, encryptionId=e1b0583884b, topicName=新方法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c22f171, createdName=kord1982, createdTime=Wed Oct 11 06:16:00 CST 2017, time=2017-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1786169, encodeId=4cb61e861692e, content=<a href='/topic/show?id=569f13e9045' target=_blank style='color:#2F92EE;'>#Pathol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13790, encryptionId=569f13e9045, topicName=Pathol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Tue May 30 11:16:00 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180545, encodeId=1325180545e2, content=henhap, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Fri Mar 17 08:59:24 CST 2017, time=2017-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180337, encodeId=656718033eff, content=要是再详细些就好了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=910e1743423, createdName=kehan, createdTime=Thu Mar 16 13:50:05 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180312, encodeId=b5e718031205, content=文章不错,值得分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Thu Mar 16 10:48:31 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180295, encodeId=0dcd18029561, content=文章不错,值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Mar 16 10:00:49 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180288, encodeId=fccd18028838, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib0kbzef1jKfxVxKKxoGdVMdMe54JuaABgJlOdkfVdUkxEReXZyZ0PMHhxlzMkiciaPAp2gJsoIbGKtA/0, createdBy=a2d51960177, createdName=komasun, createdTime=Thu Mar 16 09:30:20 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180283, encodeId=303218028350, content=很好,看看结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Thu Mar 16 08:47:58 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180281, encodeId=a57818028129, content=看看咯巴啦啦结局, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38b31934560, createdName=葫芦糊涂, createdTime=Thu Mar 16 08:45:41 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180280, encodeId=369c1802808c, content=学习了,希望有更多这样的咨询, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuMR3WZ1VnSfbWUadIWeyMyS20yXZARSoSoYng9V8Qjz3mK7SsCiazXVErDamlfgtiaWXjP1nv3I2tX/0, createdBy=94ef2037358, createdName=小太阳馒头, createdTime=Thu Mar 16 08:39:50 CST 2017, time=2017-03-16, status=1, ipAttribution=)]
    2017-03-16 葫芦糊涂

    看看咯巴啦啦结局

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1903192, encodeId=2d1a190319249, content=<a href='/topic/show?id=e1b0583884b' target=_blank style='color:#2F92EE;'>#新方法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58388, encryptionId=e1b0583884b, topicName=新方法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c22f171, createdName=kord1982, createdTime=Wed Oct 11 06:16:00 CST 2017, time=2017-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1786169, encodeId=4cb61e861692e, content=<a href='/topic/show?id=569f13e9045' target=_blank style='color:#2F92EE;'>#Pathol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13790, encryptionId=569f13e9045, topicName=Pathol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Tue May 30 11:16:00 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180545, encodeId=1325180545e2, content=henhap, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Fri Mar 17 08:59:24 CST 2017, time=2017-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180337, encodeId=656718033eff, content=要是再详细些就好了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=910e1743423, createdName=kehan, createdTime=Thu Mar 16 13:50:05 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180312, encodeId=b5e718031205, content=文章不错,值得分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Thu Mar 16 10:48:31 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180295, encodeId=0dcd18029561, content=文章不错,值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Mar 16 10:00:49 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180288, encodeId=fccd18028838, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib0kbzef1jKfxVxKKxoGdVMdMe54JuaABgJlOdkfVdUkxEReXZyZ0PMHhxlzMkiciaPAp2gJsoIbGKtA/0, createdBy=a2d51960177, createdName=komasun, createdTime=Thu Mar 16 09:30:20 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180283, encodeId=303218028350, content=很好,看看结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Thu Mar 16 08:47:58 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180281, encodeId=a57818028129, content=看看咯巴啦啦结局, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38b31934560, createdName=葫芦糊涂, createdTime=Thu Mar 16 08:45:41 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180280, encodeId=369c1802808c, content=学习了,希望有更多这样的咨询, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuMR3WZ1VnSfbWUadIWeyMyS20yXZARSoSoYng9V8Qjz3mK7SsCiazXVErDamlfgtiaWXjP1nv3I2tX/0, createdBy=94ef2037358, createdName=小太阳馒头, createdTime=Thu Mar 16 08:39:50 CST 2017, time=2017-03-16, status=1, ipAttribution=)]
    2017-03-16 小太阳馒头

    学习了,希望有更多这样的咨询

    0

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