Prostate Cancer P D：雄激素阻断治疗前列腺癌男性中的并发症研究

2018-05-08 AlexYang MedSci原创

雄激素阻断治疗使用的增加促进了人们对其副作用进一步的评估，因为这种疗法也许能够加速或者增加发展新并发症疾病的风险。最近，有研究人员评估了澳大利亚前列腺癌男性接受雄激素阻断治疗后的并发症情况。研究发现，与对照组相比，研究中的前列腺癌群体具有发展为心血管疾病显著更高的风险（风险比：1.37， 95% CI： 1.26-1.48）、以及抑郁（1.86， 95% CI： 1.73-2.01）、糖尿病（1.

雄激素阻断治疗使用的增加促进了人们对其副作用进一步的评估，因为这种疗法也许能够加速或者增加发展新并发症疾病的风险。最近，有研究人员评估了澳大利亚前列腺癌男性接受雄激素阻断治疗后的并发症情况。

研究发现，与对照组相比，研究中的前列腺癌群体具有发展为心血管疾病显著更高的风险（风险比：1.37， 95% CI： 1.26-1.48）、以及抑郁（1.86， 95% CI： 1.73-2.01）、糖尿病（1.30， 95% CI： 1.15-1.47）、胃酸障碍（1.48， 95% CI： 1.39-1.57）、高脂血症（1.18， 95% CI： 1.09-1.29）、骨质疏松症（1.65， 95% CI： 1.48-1.85）和疼痛/疼痛炎症（1.47， 95% CI： 1.39-1.55）。另外，心血管情况和抑郁的风险比在第一年是最高的，之后随着时间的推移下降。在反应性呼吸道疾病和阿茨海默疾病中，2个小组没有显著的差异。

最后，研究人员指出，与那些没有接受雄激素阻断治疗的男性相比，进行雄激素阻断治疗的前列腺癌的男性具有发展为新并发症更高的可能性。他们的结果支持了发展协调护理模式的需要，从而有效的抑制前列腺癌生存者的多种慢性疾病的发展。

原始出处：

Huah Shin Ng， Bogda Koczwara， David Roder et al. Development of comorbidities in men with prostate cancer treated with androgen deprivation therapy： an Australian population-based cohort study. Prostate Cancer P D. 02 May 2018.

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2018-06-30 41514497@qq.com

#阻断#

64 0
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2018-11-18 丁鹏鹏

#并发#

73 0
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2018-05-10 lsndxfj

#ROS#

83 0
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2018-05-10 楚钟

#雄激素阻断治疗#

70 0
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2018-05-10 sunylz

#PRO#

57 0
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2018-05-09 kafei

学习学习谢谢分享

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