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Stroke:急性缺血性卒中如何实现个体化的院前分流

2019-02-01 国际循环编辑部 国际循环

直接将患者转运至能行血管内治疗的中心,可使急性缺血性卒中患者获益,但也可能因静脉治疗延迟而给患者带来伤害。那么,对于急性缺血性卒中患者,临床实践中到底应如何进行个体化的院前分流?

直接将患者转运至能行血管内治疗的中心,可使急性缺血性卒中患者获益,但也可能因静脉治疗延迟而给患者带来伤害。那么,对于急性缺血性卒中患者,临床实践中到底应如何进行个体化的院前分流?

近期,Stroke发表的一项最新研究就急性缺血性卒中患者的最佳院前转运策略进行探讨,并对影响上述决策的因素进行分析。研究创建了决策树模型比较转运至初级卒中中心及更远距离干预中心的缺血性卒中患者的结局,根据患者特征、地理位置及工作流程时间评估最佳转运策略。通常情况下,初级卒中中心与干预中心的转运时间分别是20 min和45 min。其中,城市地区,上述两中心的转运时间分别为10 min和20 min,农村地区上述转运时间分别为30 min和90 min。对城市及农村地区的转运情况作敏感性分析。

结果发现,一般情况下,直接将患者转运之干预中心有助于改善预后,尤其是在缺血性卒中由大血管闭塞导致的可能性超过33%时。大血管闭塞可能性较高(66%,相当于快速动脉闭塞评分≥5),直接将患者转运至干预中心的获益是0.19质量调整生命年。在城市地区,当大血管闭塞风险≥24%时将患者直接转运至干预中心能给患者带来获益;在农村地区,患者大血管闭塞风险≥49%时直接转运至干预中心对患者有益。进一步分析发现,门针时间、入院到腹股沟穿刺的时间以及 DIDO(door-in-door-out)时间均为影响转运决策的因素。

综上可见,对于疑似卒中患者而言,最佳的院前转运策略需根据大血管闭塞的可能性、转运时间以及院内相应工作流程的时间决定。基于上述特征构建决策模型,有助于实现个体化的院前分流,尤其是在偏远地区。

原始出处:
Esmee Venema, Hester F. Lingsma, Vicky Chalos, et al. Personalized Prehospital Triage in Acute Ischemic Stroke. Stroke. Jan 2019.

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    2019-02-01 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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