2016基于肠促胰素治疗药物临床应用的快速建议指南发布

2016-07-12 MedSci MedSci原创

肠促胰素( incretin) 是一种经食物刺激后由肠道细胞分泌入血、能够刺激胰岛素分泌的激素。基于肠促胰素的治疗药物(incretin based therapies， IBTs)通过与器官上的特异性受体结合，从而发挥其降糖作用。由于这类药物具有低血糖风险小和改善胰岛细胞功能等多方面的优势，逐渐在临床广泛使用。目前在国内已经上市了2种胰升糖素样肽1受体激动剂( glucagon-like pe

肠促胰素( incretin) 是一种经食物刺激后由肠道细胞分泌入血、能够刺激胰岛素分泌的激素。基于肠促胰素的治疗药物(incretin based therapies， IBTs)通过与器官上的特异性受体结合，从而发挥其降糖作用。由于这类药物具有低血糖风险小和改善胰岛细胞功能等多方面的优势，逐渐在临床广泛使用。目前在国内已经上市了2种胰升糖素样肽1受体激动剂( glucagon-like peptide-1 receptor agonists， GLP-1RA) :包括艾塞那肽( exenatide) 和利拉鲁肽( liraglutide) ，5种二肽基肽酶郁抑制剂 ( dipeptidyl peptidase-4 inhibitor， DPP-4i) :包括西格列汀( sitagliptin) 、维格列汀( vildagliptin ) 、沙格列汀( saxagliptin ) 、利格列汀(linagliptin)和阿格列汀( alogliptin) ，以及 2 种复方制剂。

基于肠促胰素的治疗药物的出现为临床医生提供了更多选择，但它们的有效性、安全性和经济性究竟如何? 基于肠促胰素的治疗药物在特殊人群(如老年患者等)中使用有哪些注意事项? 特别是当这些药物所基于的大量证据都来自于欧美发达国家时，我们该如何评价、选择和应用? 这些问题都有待于采用系统、科学的方法来回答。

随着降糖药物的种类不断增加，各学(协)会于2015年陆续更新出版2型糖尿病的相关治疗指南，但未对基于肠促胰素的治疗药物在临床的具体应用进行详细的阐述。2014年1月，中华医学会糖尿病分会制定了《基于胰高血糖素样肽1降糖药的临床应用共识》，对指导临床用药起到了积极的推动作用，然而该共识主要基于专家的意见，未对证据进行全面的检索和评价。因此在全面更新我国上市的 7种基于肠促胰素治疗药物的临床证据的基础上，中华医学会内分泌学分会和中国药学会医院药学专业委员会按照循证指南制定的方法与步骤，组建多学科团队，通过调查临床使用中的实际问题，根据这些问题制定了《基于肠促胰素治疗药物临床应用的快速建议指南》，以期为临床医生和临床药师提供更符合临床实践需求的科学和具体的指导。

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会议推荐：
2016天然药物研讨会——探索与发现
http://www.bioon.com/z/2016natural-products/Index.shtml

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2017-02-04 clmlylxy

#临床应用#

48 0
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2016-09-07 周虎

#治疗药物#

76 0
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2016-12-25 xfpan12

#肠促胰素#

0 0
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2016-09-21 1e10c84am36(暂无匿称)

文章很好，非常有益

119 0
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2016-09-13 舒心和人

规范的用药指导对医生成长很有利，对患者病情恢复更有利，学习了，感谢分享

95 0
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2016-07-13 QQ76174b26

挺好的啊，学习

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2016基于肠促胰素治疗药物临床应用的快速建议指南发布

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