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利用Nichi葡聚糖变体控制新冠肺炎引发的细胞因子风暴和凝血病标志物;同类首创临床研究报告

2021-10-15 国际文传 网络

IL-6、D二聚体长期处治良好,具有可带来临床益处的免疫调节作用。

一项预初研究显示,通过食用来自日本的Nichi葡聚糖食品补剂的两种变体,可控制细胞因子风暴和凝血病(可危及生命的新冠肺炎主要并发症)的生物标志物白介素6和D二聚体。Nichi葡聚糖摄入者的下列免疫参数优于未摄入者:中性粒细胞与淋巴细胞(NLR)、淋巴细胞与c反应蛋白(LCR)、白细胞与c反应蛋白(LeCR)的比率,以及CD4CD8水平,该结果发表于同行评议期刊《生物医学和药物疗法》(Biomedicine and Pharmacotherapy) (https://www.sciencedirect.com/science/article/pii/S0753332221010271)。

SARS-COV-2病毒所致新冠肺炎感染可导致若干并发症,受累者由于免疫系统反应过度可发生细胞因子风暴,应通过免疫调节来避免。据该论文第一作者Raghavan博士表示,黑酵母Aureobasidium PullulansAFO-202菌株产生的Nichi葡聚糖可增强免疫系统,而N-163菌株产生的Nichi葡聚糖REFIX可高效调节免疫,可帮助避免任何灾难性后果。他补充道,两者联用已产生令人鼓舞的转归,我们的解释依据来自此项研究以及健康志愿者的临床前和临床研究(https://doi.org/10.1101/2021.08.05.21261640)。

NLR、LCR和LeCR等标准最近在评估新冠肺炎严重程度方面取得重要意义,我们已在健康人群和临床前研究中载明Nichi葡聚糖摄入具有优势(https://www.researchsquare.com/article/rs-771315/v1)。该研究的结论是,Nichi葡聚糖变体拥有二十多年的安全记录,已被证明能够以平衡方式处理免疫系统,而β葡聚糖有望通过脑小胶质细胞发挥作用(《神经科学杂志》(Journal of the neurological sciences);https://www.jns-journal.com/article/S0022-510X(21)00248-3/fulltext),也可能有助于应对长期新冠肺炎。

上世纪八十年代,受进化论启发,Noboru Fujii教授开始探索这种被大自然赋予多种极端耐受性的真菌。研发团队认为,在生命树上 定位介于动植物界之间的的这种益生元产品与肠道微生物组的共生可能揭示其对人类健康的多重有益效应背后的机制。

GN Corporation拥有Nichi葡聚糖全球独家经销权,正在开展精心研究,以发掘这种黑酵母真菌产生的几种菌株未被开发的潜力,并计划开展更大规模的研究。

 

Nichi葡聚糖和Nichi葡聚糖REFIX Beta 1,3-1,6葡聚糖,由黑酵母Aureobasidium Pullulans的AFO-202和N-163菌株产生,与其他Beta葡聚糖不同,此类葡聚糖是具有更高纯度和独特结构的外多糖,这被认为是它们对人类健康产生多重益处的原因,包括这项新冠肺炎患者临床研究报告的益处。(图示:美国商业资讯)

Nichi葡聚糖和Nichi葡聚糖REFIX Beta 1,3-1,6葡聚糖,由黑酵母Aureobasidium Pullulans的AFO-202和N-163菌株产生,与其他Beta葡聚糖不同,此类葡聚糖是具有更高纯度和独特结构的外多糖,这被认为是它们对人类健康产生多重益处的原因,包括这项新冠肺炎患者临床研究报告的益处。(图示:美国商业资讯)

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    2021-10-17 diushouji

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